Intermediates for the preparation of phenylsulfonylurea herbicides and plant growth regulators

ABSTRACT

The compounds of the formula (I)   &lt;IMAGE&gt; (I)  in which R1-R4, W, X, Y and Z are as defined in claim 1 are suitable for controlling harmful plants in crops. Their preparation may employ the intermediates of the formulae II and III:   &lt;IMAGE&gt; (II)  &lt;IMAGE&gt; (III)

This application is a continuation-in-part of application Ser. No. 08/144,895, filed Oct. 28, 1993, now U.S. Pat. No. 5,449,812, the disclosure of which application is expressly incorporated herein by reference.

The invention relates to the technical field of herbicides and plant growth regulators, especially herbicides for the selective control of gramineous and other weeds in crops.

It is known that phenylsulfonylureas which are substituted by heterocycles and carry on the phenyl ring an amino group which may be functionalized possess herbicidal and plant growth-regulating properties (EP-A-1 515, U.S. Pat. No. 4,892,946; U.S. Pat. No. 4,981,509; EP-A-116 518, U.S. Pat. No. 4,664,695 and U.S. Pat. No. 4,632,695).

It has now been found that, surprisingly, certain phenylsulfonylureas substituted by heterocycles are particularly highly suitable as herbicides or plant growth regulators.

The present invention relates to compounds of the formula (I) or salts thereof ##STR3## in which R¹ is C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the 3 latter radicals independently of one another being unsubstituted or substituted by one or more radicals from the group comprising halogen, C₁ -C₄ -alkoxy, CONH₂, C₁ -C₄ -alkylthio, CN, CHO, (C₁ -C₆ -alkyl)carbonyl, (C₃ -C₆ -cycloalkyl)carbonyl, C₁ -C₄ -alkylsulfonyl, carboxyl, (C₁ -C₄ -alkoxy)carbonyl, (C₂ -C₄ -alkenyloxy)carbonyl, (C₂ -C₄ -alkynyloxy)carbonyl, NO₂, NH₂, mono- and di-(C₁ -C₆)-alkylamino,

R² is CO--R⁵, COO--R⁶, CO--SR⁷, CO--NR⁸ R⁹, CS--NR¹⁰ R¹¹, CS--OR¹², CS--SR¹³, SO₂ R¹⁴, SO₂ NR¹⁵ R¹⁶,

R³ is COR¹⁷, CO--OR¹⁸, CO--NR¹⁹ R²⁰, CO--SR²¹, CO--O--N═CR²² R²³, CSR²⁴, CSSR²⁵, CS--OR²⁶, CS--NR²⁷ R²⁸, C(═NR²⁹)R³⁰,

R⁴ is H, C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the 3 latter radicals independently of one another being unsubstituted or substituted by one or more halogen radicals,

R⁵ is H, C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the three latter radicals independently of one another being unsubstituted or substituted by one or more radicals from the group comprising halogen, C₁ -C₄ -alkoxy, C₁ -C₄ -alkylthio and NR³¹ R³², or unsubstituted or substituted C₃ -C₈ -cycloalkyl, unsubstituted or substituted phenyl, unsubstituted or substituted heteroaryl or phenyl-C₁ -C₄ -alkyl which is unsubstituted or substituted on the phenyl ring,

R⁶ is C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the three latter radicals independently of one another being unsubstituted or substituted by one or more radicals from the group comprising halogen, C₁ -C₄ -alkoxy, C₁ -C₄ -alkylthio and NR³¹ R³², or C₃ -C₆ -cycloalkyl which is unsubstituted or substituted by one or more radicals from the group comprising halogen, C₁ -C₄ -alkyl and C₁ -C₄ -alkoxy, or C₃ -C₆ -cycloalky-C₁ -C₃ -alkyl,

R⁷ is analogous to R⁶

R⁸ is H, C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the 3 latter radicals independently of one another being unsubstituted or substituted by one or more radicals from the group comprising halogen, or (C₁ -C₆ -alkoxy)carbonyl or C₁ -C₄ -alkoxy,

R⁹ is H, C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the 3 latter radicals independently of one another being unsubstituted or substituted by one or more radicals from the group comprising halogen, C₁ -C₄ -alkoxy, C₁ -C₄ -alkylthio and NR³¹ R³², or CO--R³³, CO--OR³⁴, CO--NR³⁵ R³⁶, CS--NR³⁵ R³⁶, CS--R³³ or CS--OR³⁴, or

R⁸, R⁹ taken together are a divalent radical of the formula --(CH₂)₄ --, --(CH₂)₅ --, --CH₂ CH₂ --O--CH₂ CH₂ --, --CH₂ CH₂ NHCH₂ CH₂ --, the 4 latter radicals being unsubstituted or substituted by C₁ -C₄ -alkyl,

R¹⁰ is analogous to R⁸,

R¹¹ is analogous to R⁹,

R¹² is analogous to R⁶,

R¹³ is analogous to R⁶,

R¹⁴ is C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the three latter radicals independently of one another being unsubstituted or substituted by one or more radicals from the group comprising halogen, C₁ -C₄ -alkoxy, C₁ -C₄ -alkylthio and NR³¹ R³²,

R¹⁵ is analogous to R⁸,

R¹⁶ is H, C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the 3 latter radicals independently of one another being unsubstituted or substituted by one or more halogen radicals,

R¹⁷ is analogous to R⁵,

R¹⁸ is C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the three latter radicals independently of one another being unsubstituted or substituted by one or more radicals from the group comprising halogen, C₁ -C₄ -alkoxy, C₁ -C₄ -alkylthio and NR³¹ R³², or C₃ -C₆ -cycloalkyl which is unsubstituted or substituted by one or more radicals from the group comprising halogen, C₁ -C₄ -alkyl and C₁ -C₄ -alkoxy, or C₃ -C₆ -cycloalkyl-C₁ -C₃ -alkyl or H,

R¹⁹ is analogous to R⁸,

R²⁰ is analogous to R⁹,

R²¹ is analogous to R¹⁸,

R²² is H, C₁ -C₄ -alkyl, C₃ -C₅ -alkenyl or C₃ -C₅ -alkynyl,

R²³ is H, C₁ -C₄ -alkyl, C₃ -C₅ -alkenyl or C₃ -C₅ -alkynyl,

R₂₄ is analogous to R¹⁷,

R²⁵ is analogous to R¹⁸,

R²⁶ is analogous to R¹⁸,

R²⁷ is analogous to R⁸,

R²⁸ is analogous to R⁹,

R²⁹ is H, OH, NH₂, NHR³⁷, N(R³⁷)₂, C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₂ -C₄ -alkenyl or C₂ -C₄ -alkynyl, the 4 latter radicals independently of one another being unsubstituted or substituted by one or more radicals from the group comprising halogen, C₁ -C₃ -alkoxy and C₁ -C₃ -alkylthio,

R³⁰ is H, C₁ -C₆ -alkyl, C₁ -C₆ -alkoxy, C₂ -C₆ alkenyl, C₂ -C₆ -alkynyl, the four latter radicals independently of one another being unsubstituted or substituted by one or more radicals from the group comprising halogen, C₁ -C₃ -alkoxy and C₁ -C₃ -alkylthio,

each

R³¹ independently of the others is H, C₁ -C₄ -alkyl, (C₁ -C₄ -alkyl)carbonyl, (C₁ -C₄ -alkoxy)carbonyl or CHO,

each

R³² independently of the others is H or C₁ -C₄ -alkyl,

R³³ is analogous to R⁵,

R³⁴ is analogous to R⁶,

R³⁵, R³⁶ independently of one another are H, C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the 3 latter radicals independently of one another being unsubstituted or substituted by one or more halogen radicals,

R³⁷ is C₁ -C₄ -alkyl, C₂ -C₄ -alkenyl or C₂ -C₄ -alkynyl, the three radicals mentioned, independently of one another, being unsubstituted or substituted by one or more radicals from the group comprising halogen, C₁ -C₄ -alkoxy and C₁ -C₄ -alkylthio,

W is O or S,

X and Y independently of one another are hydrogen, halogen, C₁ -C₆ -alkyl, C₁ -C₆ -alkoxy or C₁ -C₆ -alkylthio, the three latter radicals being unsubstituted or substituted by one or more radicals from the group comprising halogen, C₁ -C₄ -alkoxy and C₁ -C₄ -alkylthio, or mono- or di-(C₁ -C₄ -alkyl)amino, C₃ -C₆ -cycloalkyl, C₃ -C₅ -alkenyl, C₃ -C₅ -alkenyloxy or C₃ -C₅ -alkynyloxy, and

Z is CH or N.

In the formula (I) and below, each of the radicals alkyl, alkoxy, haloalkyl, haloalkoxy, alkylamino and alkylthio, and the corresponding unsaturated and/or substituted radicals may be straight-chain or branched in the carbon structure. If not indicated specifically, the carbon structures having from 1 to 4 carbon atoms or, in the case of unsaturated groups, having from 2 to 4 carbon atoms are preferred for these radicals. Examples of alkyl radicals, including those in the composite definitions such as alkoxy, haloalkyl etc., are methyl, ethyl, n- or i-propyl, n-, i-, t- or 2-butyl, pentyls, hexyls such as n-hexyl, i-hexyl and 1,3-dimethylbutyl, heptyls such as n-heptyl, 1-methylhexyl and 1,4-dimethylpentyl; alkenyl and alkynyl radicals have the meaning of the unsaturated radicals corresponding, where possible, to the alkyl radicals, examples of alkenyl are allyl, 1-methylprop-2-en-1-yl, 2-methylprop-2-en-1-yl, but-2-en-1-yl, but-3-en-1-yl, 1-methylbut-3-en-1-yl, 1-methylbut-2-en-1-yl and 1-methylbut-2-en-1-yl; examples of alkynyl are propargyl, but-2-yn-1-yl, but-3yn-1-yl and 1-methylbut-3-yn-1-yl.

Halogen is fluorine, chlorine, bromine or iodine. Haloalkyl, haloalkenyl and haloalkynyl are respectively alkyl, alkenyl and alkynyl which are partially or completely substituted by halogen, preferably by fluorine, chlorine and/or bromine and in particular by fluorine or chlorine; examples are CF₃, CHF₂, CH₂ F, CF₃ CF₂, CH₂ FCHCl, CCl₃, CHCl₂, CH₂ CH₂ Cl; examples of haloalkoxy are OCF₃, OCHF₂, OCH₂ F, CF₃ CF₂ O, OCH₂ CF₃ and OCH₂ CH₂ Cl. This applies correspondingly to haloalkenyl and other halo-substituted radicals.

Aryl is a mono-, bi- or polycyclic aromatic system, for example phenyl, naphthyl, tetrahydronaphthyl, indenyl, indanyl, pentalenyl, fluoranyl and the like, preferably phenyl; aryloxy preferably comprises the oxy radicals corresponding to the aryl radicals mentioned, in particular phenoxy.

Heteroaryl is a mono-, bi- or polycyclic aromatic system in which at least 1 ring contains one or more heteroatoms, for example pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, thienyl, thiazolyl, oxazolyl, furyl, pyrrolyl, pyrazolyl and imidazolyl, but also bicyclic or polycyclic aromatic or araliphatic compounds, e.g. quinolinyl, benzoxazolyl etc.

A substituted aryl, heteroaryl, phenyl, benzyl or substituted bicyclic radical containing aromatic structures is, for example, a substituted radical derived from the unsubstituted parent structure, examples of substituents being one or more radicals, preferably 1, 2 or 3 radicals from the group comprising halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, hydroxyl, amino, nitro, cyano, alkoxycarbonyl, alkylcarbonyl, formyl, carbamoyl, mono- and dialkylaminocarbonyl, mono- and dialkylamino, alkylsulfinyl and alkylsulfonyl and, in the case of radicals containing carbon atoms, those having from 1 to 4 carbon atoms, in particular 1 or 2 carbon atoms, being preferred. Preferred substituents in general are those from the group comprising halogen, e.g. fluorine and chlorine, C₁ -C₄ -alkyl, preferably methyl or ethyl, C₁ -C₄ -haloalkyl, preferably trifluoromethyl, C₁ -C₄ -alkoxy, preferably methoxy or ethoxy, C₁ -C₄ -haloalkoxy, nitro and cyano. Particularly preferred substituents are methyl, methoxy and chlorine.

Substituted or unsubstituted phenyl is, for example, phenyl which is unsubstituted or substituted once or more than once, preferably up to three times, by identical or different radicals from the group comprising halogen, C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₁ -C₄ -haloalkyl, C₁ -C₄ -haloalkoxy and nitro, e.g. o-, m- and p-tolyl, dimethylphenyls, 2-, 3- and 4-chlorophenyl, 2,3,4-trifluoro- and -trichlorophenyl, 2,4-, 3,5-, 2,5- and 2,3-dichlorophenyl, o-, m- and p-methoxyphenyl.

A heteroaromatic radical or heterocyclic radical preferably has 5 or 6 members and contains 1, 2 or 3 heteroatoms, preferably from the group comprising N, O and S. The radical may be benzo-fused. Suitable radicals are those such as oxiranyl, pyrrolidinyl, piperidyl, dioxolanyl, pyrazolyl, morpholyl, furyl, tetrahydrofuryl, indolyl, quinolinyl, pyrimidyl, azepinyl, imidazolyl, triazolyl, thienyl and oxazolyl.

The invention also relates to all the stereoisomers encompassed by formula (I), and mixtures thereof. These compounds of the formula (I) contain one or more asymmetric carbon atoms or double bonds which are not indicated specifically in the formula (I). Formula (I) encompasses all the stereoisomers defined by their specific spatial orientation, such as enantiomers, diastereomers, Z- and E-isomers, all of which can be prepared by conventional methods from mixtures of the stereoisomers or else by stereoselective reactions in combination with the use of stereochemically pure starting substances.

The compounds of the formula (I) may form salts in which the hydrogen of the --SO₂ --NH-- group or else another acidic hydrogen atom (e.g. from COOH etc.) is replaced by a cation which is suitable for agriculture. Examples of these salts are metal salts, in particular alkali metal or alkaline earth metal salts, or else ammonium salts or salts with organic amines. The formation of a salt can also take place by the addition of an acid to basic groups such as amino and alkylamino. Suitable acids in this respect are strong inorganic and organic acids, for example HCl, HBr, H₂ SO₄ or HNO₃.

Primarily for reasons of greater herbicidal activity, improved selectivity and/or increased ease of preparation, compounds of the formula (I) or salts thereof of particular interest are those in which

R¹ is C₁ -C₄ -alkyl, C₂ -C₄ -alkenyl or C₂ -C₄ -alkynyl, preferably C₁ -C₄ -alkyl, allyl or propargyl, or

R² is CO--R⁵, COOR⁶, CO--NR⁸ R⁹, CS--NR¹⁰ R¹¹, SO₂ R¹⁴ or SO₂ NR¹⁵ R¹⁶, or

R³ is COR¹⁷, COOR¹⁸, CONR¹⁹ R²⁰ or CO--ON═CR²² R²³, preferably COOR¹⁸, or

R⁴ is H or C₁ -C₄ -alkyl, preferably H or methyl, or

R⁵ is H, C₁ -C₆ -alkyl which is unsubstituted or substituted by one or more radicals from the group comprising halogen, or by C₁ -C₄ -alkoxy, C₁ -C₄ -alkylthio or NR³¹ R³², or C₃ -C₆ -cycloalkyl, unsubstituted or substituted phenyl, unsubstituted or substituted benzyl or unsubstituted or substituted heteroaryl, preferably H, C₁ -C₆ -alkyl, C₁ -C₄ -haloalkyl, cyclopropyl, cyclopentyl, cyclohexyl, phenyl or heteroaryl, the two latter radicals being unsubstituted or substituted by one or more radicals from the group comprising C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy and halogen, or

R⁶ is C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alklynyl, C₁ -C₆ -haloalkyl or C₃ -C₆ -cycloalkyl, preferably C₁ -C₄ -alkyl, C₁ -C₄ -haloalkyl, allyl, propargyl or C₃ -C₆ -cycloalkyl, or

R⁷ is C₁ -C₄ -alkyl,

R⁸ is hydrogen, C₁ -C₆ -alkyl, C₁ -C₄ -haloalklyl, C₁ -C₄ -alkoxy or (C₁ -C₄ -alkoxy)carbonyl,

R⁹ is hydrogen, C₁ -C₆ -alkyl which is unsubstituted or substituted by one or more radicals from the group comprising halogen, C₁ -C₄ -alkoxy and NR³¹ R³², or CO--R³³, CO--OR³⁴ or CO--NR³⁵ R³⁶, or

R⁸ and R⁹ taken together are a divalent radical of the formula --(CH₂)₄ --, --(CH₂)₅ -- or --CH₂ CH₂ --O--CH₂ CH₂ --, or

R¹⁴ is C₁ -C₆ -alkyl or C₁ -C₆ -haloalkyl, preferably C₁ -C₄ -alkyl or C₁ -C₄ -haloalkyl, or

R¹⁵, R¹⁶ independently of one another are hydrogen or C₁ -C₄ -alkyl, or

R¹⁷ is hydrogen or C₁ -C₄ -alkyl, C₁ -C₄ -haloalkyl, C₃ -C₆ -cycloalkyl, phenyl or heteroaryl, the two latter radicals being unsubstituted or substituted, or

R¹⁸ is hydrogen, C₁ -C₄ -alkyl, C₂ -C₆ -alkenyl or C₂ -C₆ -alkynyl, the 3 latter radicals being unsubstituted or substituted by one or more radicals from the group comprising halogen, C₁ -C₄ -alkoxy, C₁ -C₄ -alkylthio and NR³¹ R³², or C₃ -C₆ -cycloalkyl or C₃ -C₆ -cycloalkyl-C₁ -C₃ -alkyl, or

R²² is hydrogen or C₁ -C₂ -alkyl, or

R²³ is hydrogen or C₁ -C₂ -alkyl, or

R²⁹ is hydrogen, hydroxyl, amino, NHCH₃, N(CH₃)₂, C₁ -C₄ -alkyl or C₁ -C₄ -alkoxy,

R³⁰ is hydrogen or C₁ -C₄ -alkyl, or

each

R³¹ independently of the others is H or C₁ -C₄ -alkyl, or

each

R³² independently of the others is H or C₁ -C₄ -alkyl, or

R³³ is hydrogen, C₁ -C₄ -alkyl, C₁ -C₄ -haloalkyl, C₃ -C₆ -cycloalkyl or phenyl which is unsubstituted or substituted by one or more radicals from the group comprising halogen, C₁ -C₄ -alkyl and C₁ -C₄ -alkoxy, or

R³⁴ is C₁ -C₄ -alkyl, allyl, propargyl or cycloalkyl, or

R³⁵ is hydrogen or C₁ C₄ -alkyl, or

R³⁶ is hydrogen or C₁ -C₄ -alkyl, or

X is C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₁ -C₄ -haloalkyl, C₁ -C₄ -alkylthio, halogen or mono- or di-(C₁ -C₂ -alkyl)amino, preferably methyl, ethyl, methoxy, ethoxy, methylthio, ethylthio, chlorine, NHCH₃ or N(CH₃)₂, or

Y is C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₁ -C₄ -haloalkyl or C₁ -C₄ -alkylthio, preferably methyl, ethyl, methoxy or ethoxy,

or preferably those compounds of the formula (I) or salts thereof in which two or more of the particular or preferred definitions mentioned above for the radicals R¹ to R³⁶ in formula (I) are present in combination.

Preferred compounds of the formula (I) or salts thereof are those in which

R¹ is methyl, ethyl, n-propyl, i-propyl or allyl,

R² is CO--R⁵, COOR⁶, CO--NR⁸ R⁹, CS--NR¹⁰ R¹¹, SO₂ R¹⁴ or SO₂ NR¹⁵ R¹⁶,

R⁵ is H, C₁ -C₄ -alkyl, C₁ -C₂ -haloalkyl, cyclopropyl, phenyl, benzyl or hereroaryl having 5 or 6 ring atoms, the 3 latter radicals being unsubstituted or substituted by one or more halogen atoms,

R⁶ is C₁ -C₄ -alkyl, allyl, propargyl or cyclopropyl,

R⁸ is H, C₁ -C₄ -alkyl, C₁ -C₄ -haloalkyl or (C₁ -C₄ -alkoxy)carbonyl,

R⁹ is H or C₁ -C₄ -alkyl,

R¹⁰ is H or C₁ -C₄ -alkyl,

R¹¹ is H or C₁ -C₄ -alkyl,

R¹⁴ is C₁ -C₄ -alkyl,

R¹⁵ is H or C₁ -C₄ -alkyl and

R¹⁶ is H or C₁ -C₄ -alkyl.

R⁵ is particularly preferably H, CH₃, C₂ H₅, n- or i-C₃ H₇, n-, i-, t- or 2-butyl, n-pentyl, CF₃, CH₂ Cl, CHCl₂, CCl₃, CH₂ Br, CH₂ CCl₃, cyclopropyl, phenyl, thienyl, furyl or pyridyl, in which case the 4 latter radicals may be substituted by from 1 to 3 halogen atoms.

The present invention also relates to processes for the preparation of the compounds of the formula (I) according to the invention or salts thereof, which comprises

a) reacting a compound of the formula (II) ##STR4## with a heterocyclic carbamate of the formula (III) ##STR5## in which R* is unsubstituted or substituted phenyl or C₁ -C₄ -alkyl, or

b) reacting a sulfonyl isocyanate of the formula (IV) ##STR6## with an amino heterocycle of the formula (V) ##STR7## or c) reacting a compound of the formula (II) with a (thio)isocyanate of the formula (X) ##STR8## in the presence of a base, the radicals R¹ to R⁴, W, X, Y and Z in the above formulae (II) to (V) and (X) being as defined in formula (I) and, in the case of variants a) and b), the compounds initially obtained being those of the formula (I) in which W=O.

The reaction of the compounds of the formulae (II) and (III) is preferably carried out base-catalyzed in an inert organic solvent, for example dichloromethane, acetonitrile, dioxane or THF, at temperatures between 0° C., preferably 20° C., and the boiling point of the solvent. Examples of the base used are organic amine bases, such as 1,8-diazabicyclo 5.4.0!undec-7-ene (DBU), especially when R*=(substituted) phenyl (cf. EP-A-44 807), or trimethylaluminum or triethylaluminum, the latter especially when R*=alkyl (cf. EP-A-166 516).

The sulfonamides (II) and the sulfonyl isocyanates (IV) are new compounds. They and their preparation are also subjects of the invention.

The compounds of the formula (Ii) are obtained, for example, starting from compounds of the formula (VI) ##STR9## in which R¹, R² and R³ are as defined in formula (I), by reaction with a strong acid (cf. in this respect WO 89/10921).

Examples of suitable strong acids are mineral acids, such as H₂ SO₄ or HCl, or strong organic acids such as trifluoroacetic acid. The elimination of the tert-butyl protective group is carried out, for example, at temperatures from -20° C. to the respective reflux temperature of the reaction mixture, preferably at 0° C. to 40° C. The reaction can be carried out without solvent or else in an inert solvent, for example dichloromethane or trichloromethane.

The compounds of the formula (VI) are obtained, for example, from the compounds of the formula (VI')--which corresponds to the formula (VI) but in which R² =H-- by reaction with suitable electrophiles such as acid chlorides, acid anhydrides, isocyanates, thioisocyanates, sulfonyl chlorides or amidosulfonyl chlorides (cf. in this respect: A. L. J. Beckniter in J. Zabicky, "The Chemistry of Amides", pp. 73-185, Interscience, New York, 1970; E. J. Corey et al., Tetrahedron Lett. 1978, 1051; H. J. Saunders, R. J. Slocombe, Chem. Rev. 43, 203 (1948); S. Ozaki, Chem. Rev. 72, 457, 469 (1972) G. Zolβ, Arzneim.-Forsch. 33, 2 (1983); Houben-Weyl-Hagemann, "Methoden der organischen Chemie Methods of Organic Chemistry!", 4th edition, vol. E4, p. 485 ff., Thieme Verlag Stuttgart, 1983 J. Golinsky, M. Mahosza, Synthesis 1978, 823; Houben-Weyl-Muller, "Methoden der organischen Chemie", 4th edition, vol. IX, pp. 338-400 and 605-622, Thieme Verlag Stuttgart, 1955; Houben-Weyl-Klarmann, "Methoden der organischen Chemie", 4th edition, vol. E 11/2, pp. 1020-22, Thieme Verlag Stuttgart, 1985; S. Krishnamurthey, Tetrahedron Lett. 23, 3315 (1982)).

The N-monosubstituted aminobenzene derivatives, for example N-alkylaminobenzene derivatives, which are required for this purpose, of the formula (VI') (see formula (VI), R² =H) are obtained by monoalkylation of the anilines of the formula (VI") (=formula (VI), R¹ =H and R² =H) by standard methods. For example, the N-acylation of the anilines of the formula (VI") with carboxylic acid chlorides or carboxylic acid anhydrides gives the corresponding N-acyl-anilines. The subsequent reduction of the acylamino group to the analogous N-monosubstitutedamino group, e.g. alkylamino group (see above) using suitable reducing agents, for example borane/dimethyl sulfide complex, gives the aniline derivatives of the formula (VI') (=formula (VI), R² =H) in very good yields; see S. Krishnamurthey, Tetrahedron Lett. 23, 3315 (1982).

The aniline derivatives mentioned of the formula (VI') (=formula (VI), R¹ and R² =H) are obtained by methods known from the literature, by reduction of the nitro group in compounds (VII), for example by hydrogenation with hydrogen in the presence of a suitable catalyst, as Pd/C or Raney nickel, or by reduction with iron in a medium acidified with acetic acid. (cf. in this respect: H. Berrie, G. T. Neuhold, F. S. Spring, J. Chem. Soc. 1952, 2042; M. Freifelder, "Catalytic Hydrogenation in Organic Synthesis: Procedures and Commentary", J. Wiley and Sons, New York (1978) chapter 5).

The aromatic sulfonamides of the formula (VII) can be obtained from the sulfonic acids of the formula (VIII). ##STR10##

The sulfonic acid group in compounds (VIII) is first converted to the sulfonyl chlorides, for example by standard methods such as the reaction of phosphorus oxychloride or thionyl chloride with potassium salts of the corresponding sulfonic acids in inert solvents such as acetonitrile and/or sulfolane, or without solvent, by heating at reflux (cf. Houben-Weyl-Klamann, "Methoden der organischen Chemie", 4th edition, vol. E XI/2, pp. 1067-1073, Thieme Verlag Stuttgart, 1985).

The formation of sulfonamide from the sulfonyl chlorides using tert-butylamine in ethanol gives the compounds (VII) in good yields (cf. analogous reactions in WO 89/10921).

The sulfonic acids of the formula (VIII) can be prepared from 2-methyl-5-nitrobenzenesulfonic acid, which is available commercially.

The substituent R³ is introduced by oxidation of the methyl group of 2-methyl-5-nitrobenzenesulfonic acid using standard methods, such as the reaction with potassium permanganate to give the carboxy group, followed if desired by derivatization, for example esterification or amidation (cf. in this respect: Houben-Weyl-Falbe: "Methoden der organischen Chemie", 4th edition, vol. E V/1, Thieme Verlag Stuttgart, 1985, pp. 199-202).

A wide variation in the radical R³ can be obtained using a range of standard reactions:

Carboxylic acid amides are obtainable by reacting acid anhydrides or acid chlorides with amines (cf. in this respect: A. L. J. Beckwith in J. Zabicky, "The Chamistry of Amides", pp. 73-185, Interscience, New York 1970).

Thiocarboxylic acid S-esters can be prepared from carboxylic acids and thiols with carbonyl activation, for example using diphenylphosphinyl chloride (cf. in this respect: D. Scholz, D. Eigner, Monatsh. Chemie 110, 759 (1979), S. Yamada et al., J. Org. Chem. 39, 3302 (1974)).

Thiocarboxylic acid O-esters can be prepared by reacting carboxylic acid esters with suitable reagents, for example P₄ S₁₀ (cf. in this respect: S. O. Lauresson et al., Bull. Soc. Chim. Belg. 87, 293 (1978); T. Nishiwak et al., Chem. Lett. 1980, 401).

Thiocarboxylic acid amides are obtained from carboxylic acid amides by "sulfurization", for example with phosphorus pentasulfide (Houben-Weyl-Falbe, "Methoden der organischen Chemic", 4th edition, vol. E 5/2, pp. 1242-1247 (and literature cited therein), Thieme Verlag Stuttgart, 1985).

Aldehydes can be synthesized from carboxylic acids or esters using a range of reducing agents (Houben-Weyl-Falbe, "Methoden der organischen Chemie", 4th edition, vol. E 3, p. 418 ff., Thieme Verlag Stuttgart, 1983).

Functionalized aldehyde derivatives, for example oximes, oxime ethers, hydrazones etc., can be obtained from the aldehydes by condensation with the corresponding amines (cf. in this respect: Houben-Weyl-Muller, "Methoden der organischen Chemie", 4th edition, vol. 7/1, pp. 453-474, Thiame Verlag Stuttgart, 1954).

N-Alkoxy-carboxylic acid imide esters can be prepared from hydroxamic acid bromide derivatives and alcoholates (E. C. Tayler, F. Kienzle, J. Org. Chem. 36, 233 (1971).

Carboxylic acid imide esters can be obtained from carboxylic acid chloride imides and corresponding alcoholates (cf. in this respect: H. Bohme, O. Muller, Chem. Ber. 98, 1450 (1965); G. Bock, Chem. Ber. 100, 2870 (1967).

O-Acyl oximes can be prepared, for example, by reacting carboxylic acid anhydrides with ketoximes (cf. in this respect: S. Bittner, Y. Knobler, M. Frankel, Tetrahedron Lett. 1965, 95).

Hydroxamic acid amides can be obtained by reacting hydroxamic acid chloride derivatives with amines (cf. in this respect: Houben-Weyl-Muller, "Methoden der organisthen Chemie", 4th edition, vol. 10/4, p. 209 ff., Thieme Verlag Stuttgart, 1968).

Alternatively, the sulfonamides of the formula (II) in which R¹ and R² are not H can be obtained by aminolysis of the corresponding sulfonyl chlorides of the formula (IXb) ##STR11## which in turn are readily obtainable from the sulfonic acids (IXa) by the standard methods mentioned (see abovementioned reactions of (VIII) to (VII)).

The compounds (IXa) can in turn be obtained from the nitrobenzenesulfonic acid (VIII) by the sequence of reactions

(1) reduction by analogy with reduction of (VII),

(2) N-alkylation and

(3) N-acylation,

the latter being as described in the preparation of (VI).

The carbamates of the formula (III) which are required for the reaction of compounds (II) by variant a) are known from the literature or can be prepared by analogy with known processes (cf. EP-A-70 804 or U.S. Pat. No. 4,480,101).

The compounds of the formulae (IV) and (V) which can be employed for the process variants b) can also be prepared from the abovementioned compounds of the formulae (III) and (VIII) and their precursors by, or by analogy with, methods which are known in general terms.

The phenylsulfonyl isocyanates of the formula (IV) can be prepared, for example, by analog with the processes from EP-A-184 385 starting from compounds of the formula (II) and using, for example, phosgene.

The reaction of the compounds (IV) with the amino heterocycles of the formula (V) is preferably carried out in inert aprotic solvents, for example dioxane, acetonitrile or tetrahydrofuran, at temperatures between 0° C. and the boiling temperature of the solvent.

The (thio)isocyanates of the formula (X) can be prepared by methods known from the literature (cf. EP-A-232 067, EP-A-166 516).

The reaction of compounds of the formula (X) with sulfonamides of the formula (II) is carried out at temperatures of between -10° C. and +10° C., preferably between +20° and +80° C., in an inert aprotic solvent, for example acetone or acetonitrile, in the presence of a suitable base such as triethylemine or potassium carbonate.

The salts of the compounds of the formula (I) are preferably prepared in inert solvents such as water, methanol, acetone, dichloromethane, tetrahydrofuran, toluene or heptane, at temperatures from 0° to 100° C. Examples of bases suitable for the preparation of the salts according to the invention are alkali metal carbonates, such as potassium carbonate, alkali metal end alkaline earth metal hydroxides, ammonia or a suitable amine base, such as triethylemine or ethanolamine. Examples of acids suitable for salt formation are HCl, HBr, H₂ SO₄ or HNO₃.

The inert solvents referred to in the abovementioned process variants are in each case solvents which are inert under the respective reaction conditions, but which are not necessarily inert under any reaction conditions.

The compounds of the formula (I) according to the invention or their salts have an excellent herbicidal activity against a broad range of economically important monocotyledon and dicotyledon harmful plants. The active substances also act efficiently on perennial weeds which produce shoots from rhizomes, root stocks or other perennial organs and which are difficult to control. In this context, it does not matter whether the substances are applied before sowing, pre-emergence or post-emergence. Specifically, examples may be mentioned of some representatives of the monocotyledon and dicotyledon weed flora which can be controlled by the compounds according to the invention, without the mention intending restriction to certain species.

Examples of weed species on which the active substance acts efficiently are, from amongst the monocotyledons, Avena, Lolium, Alopecurus, Phalaris, Echinochloa, Digitaria, Setaria and also Cyperus species from the annual sector and from amongst the perennial species Agropyron, Cymodon, Imperata and Sorghum, and also perennial Cyperus species.

In the case of the dicotyledon weed species, the range of action extends to species such as, for example, Galium, Viola, Veronica, Lamium, Stellaria, Amaranthus, Sinapis, Ipomoea, Matricaria, Abutilon and Sida from amongst the annuals, and Convolvulus, Cirsium, Rumex and Artemisia in the case of the perennial weeds.

The active substances according to the invention likewise effect outstanding control of weeds which occur under the specific conditions of rice-growing, such as, for example, Sagittaria, Alisma, Eleocharis, Scirpus and Cyperus.

If the compounds according to the invention are applied to the soil surface before germination, then the weed seedlings are either prevented completely from emerging, or the weeds grow until they have reached the cotyledon stage but then their growth stops and, eventually, after three to four weeks have elapsed, they die completely.

If the active substances are applied post-emergence on the green parts of the plants, growth likewise stops drastically a very short time after the treatment and the weed plants remain at the growth stage of the point in time of application, or they die completely after a certain time, so that in this manner competition by the weeds, which is harmful to the crop plants, is eliminated at a very early point in time and in a sustained manner.

Even though the compounds according to the invention have an excellent herbicidal activity against monocotyledon and dicotyledon weeds, crop plante of economically important crops, such as, for example, wheat, barley, rye, rice, maize, sugar beet, cotton and soya, are damaged not at all, or only to a negligible extent. For these reasons, the present compounds are highly suitable for selectively controlling unwanted plant growth in agricultural crop plants.

In addition, the substances according to the invention exhibit outstanding growth-regulatory properties in crop plants. They intervene to regulate the plant metabolism and can therefore be employed so as to have a specific influence on substances contained in plants, and for facilitating harvesting, for example by initiating desiccation and growth compression. Furthermore, they are also suitable for the general control and inhibition of unwanted vegetative growth, without killing off the plants in the process. Inhibition of vegetative growth plays an important role in many monocotyledon and dicotyledon crops, since it can reduce or completely prevent lodging.

The compounds according to the invention can be used in the form of wettable powders, emulsifiable concentrates, sprayable solutions, dusting agents or granules in the conventional formulations. The invention therefore also relates to herbicidal and plant growth-regulating agents comprising compounds of the formula (I) or salts thereof.

The compounds of the formula (I) or salts thereof can be formulated in a variety of ways, as predetermined by the biological and/or chemicophysical parameters. The following possibilities are therefore suitable for formulation: wettable powders (WP), water-soluble powders (SP), water-soluble concentrates, emulsifiable concentrates (EC), emulsions (EW) such as oil-in-water and water-in-oil emulsions, sprayable solutions, suspension concentrates (SC), dispersions on an oil or water base, oil-miscible solutions, capsule suspensions (CS), dusting agents (DP) seed-dressing agents, granules for scattering and soil application, granules (GR) in the form of microgranules, sprayable granules, coated granules and adsorption granules, water-dispersible granules (WG), water-soluble granules (SG), ULV formulations, microcapsules and waxes.

These individual formulation types are known in principle and are described, for example in: Winnacker-Kuchler, "Chemische Technologie Chemical Technology!", Volume 7, C. Hauser Verlag Munich, 4th Ed., 1986; Wade van Valkenburg, "Pesticide Formulations", Marcel Dekker New York, 1973; K. Martens, "Spray Drying" Handbook, 3rd Ed. 1979, G. Goodwin Ltd. London.

The formulation auxiliaries required, such as inert materials, surfactants, solvents and other additives, are likewise known and are described, for example, in: Watkins, "Handbook of Insecticide Dust Diluent and Carriers", 2nd Ed., Darland Books, Caldwell N.J., H.v. Ophen, "Introduction to Clay Colloid Chemistry", 2nd Ed., J. Wiley & Sons, New York; C. Marsden, "Solvents Guide", 2nd Ed., Interscience, New York 1963; McCutcheon's "Detergents and Emulsifiers Annual", MC Publ. Corp. Ridgewood N.J.; Sisleyand Wood, "Encyclopedia of Surface Active Agents", Chem. Publ. Co. Inc., New York 1964; Schonfeldt, "Grenzflachenaktive Athylenoxidaddukte" Surface-active Ethylene Oxide Adducts! Wiss. Verlagsgesell., Stuttgart 1976; Winnacker-Kuchler, "Chemische Technologie Chemical Technology!", Volume 7, C. Hauser Verlag Munich, 4th Ed. 1986.

Combinations with other pesticidally active substances, such as insecticides, acaricides, herbicides, fungicides, safeners, fertilizers and/or growth regulators may also be prepared on the basis of these formulations, for example in the form of a ready-to-use formulation or as a tank mix.

Wettable powders are preparations which are uniformly dispersible in water and which, besides the active substance, also contain surfactants of ionic and/or nonionic type (wetting agents, dispersants), for example polyethoxylated alkylphenols, polyethoxylated fatty alcohols, polyethoxylated fatty amines, fatty alcohol polyglycol ether sulfates, alkanesulfonates, alkylbenzenesulfonates, sodium ligninsulfonate, sodium 2,2'-dinaphthylmethane-6,6'-disulfonate, sodium dibutylnaphthalenesulfonate, or alternatively sodium oleoylmethyltaurinate, in addition to a diluent or inert substance. The wettable powders are prepared by finely grinding the herbicidal active substances, for example, in conventional apparatus such as hammer mills, blower mills and air-jet mills, and mixing them simultaneously or subsequently with the formulation auxiliaries.

Emulsifiable concentrates are prepared by dissolving the active substance in an organic solvent, for example butanol, cyclohexanone, dimethylformamide, xylene and also higher-boiling aromatic compounds or hydrocarbons or mixtures of the organic solvents, with the addition of one or more surfactants of ionic and/or nonionic type (emulsifiers). Examples of emulsifiers which can be used are: calcium salts of an alkylarylsulfonic acid such as Ca dodecylbenzenesulfonate, or nonionic emulsifiers, such as fatty acid polyglycol asters, alkylaryl polyglycol ethers, fatty alcohol polyglycol ethers, propylene oxide/ethylene oxide condensation products, alkyl polyethers, sorbitan esters, such as sorbitan fatty acid esters or polyoxyethylene sorbitan esters, such as polyoxyethylene sorbitan fatty esters.

Dusting agents are obtained by grinding the active substance with finely divided solid substances, for example talc or natural clays, such as kaolin, bentonite, pyrophyllite or diatomaceous earth.

Suspension concentrates may be based on water or oil. They can be prepared by, for example, wet grinding using conventional bead mills with the possible addition of surfactants as already mentioned, for example, above for the other types of formulation.

Emulsions, for example oil-in-water emulsions (EW), can be prepared, for example, by means of stirrers, colloid mills and/or static mixers, using aqueous organic solvents and, if desired, surfactants, for example as already listed above for the other types of formulation.

Granules can be produced either by spraying the active substance onto adsorptive, granulated inert material or by applying active substance concentrates onto the surface of carriers, such as sand, kaolinites or granulated inert material, by means of binders, for example polyvinyl alcohol, sodium polyacrylate or, alternatively, mineral oils. Suitable active substances can also be granulated in the manner which is conventional for the production of fertilizer granules, if desired in a mixture with fertilizers.

Water-dispersible granules are generally prepared by conventional methods such as spray-drying, fluidized-bed granulation, plate granulation, mixing using high-speed mixers and extrusion without solid inert material.

The agrochemical formulations generally contain from 0.1 to 99% by weight and in particular from 0.1 to 95% by weight of active substance of the formula (I) or salts thereof.

The concentration of active substance in wettable powders is, for example, about 10 to 90% by weight; the remainder to 100% by weight is composed of conventional formulation components. In the case of emulsifiable concentrates, the concentration of active substance can be about 1 to 90, preferably 5 to 80% by weight. Formulations in the form of dusts usually contain 1 to 30, preferably 5 to 20% by weight of active substance, sprayable solutions about 0.05 to 80, preferably 2 to 50% by weight. In the case of water-dispersible granules, the active substance content depends partly on whether the active compound is liquid or solid and on which granulation auxiliaries, fillers etc. are used. In the case of the water-dispersible granules, the content of active substance is, for example, between 1 and 95% by weight and preferably between 10 and 80% by weight.

In addition, the active substance formulations mentioned contain, if appropriate, the adhesives, wetting agents, dispersants, emulsifiers, penetrants, preservatives, frost protectors and solvents, fillers, carriers and colorants, antifoams, evaporation inhibitors and agents influencing the pH and the visocity which are conventional in each case.

Combination partners which can be employed for the active substances according to the invention in mixed formulations or as a tank mix are, for example, known active substances as described in, for example, Weed Research 26, 441-445 (1986), or "The Pesticide Manual", 9th edition, The British Crop Protection Council, 1990/91, Bracknell, England, and the literature quoted therein. Examples of herbicides known from the literature which can be combined with the compounds of the formula (I) are the following active substances (note: the compounds are either given by their common name in accordance with the International Organization for Standardization (ISO) or by the chemical name, together if appropriate with a common code number):

acetochlor; acifluorfen; aclonifen; AKH 7088, i.e. 1- 5- 2-chloro-4-(trifluoromethyl)phenoxy!-2-nitrophenyl!-2-methoxyethylidene!amino!oxy!acetic acid and its methyl ester; alachlor; alloxydim; ametryn; amidosulfuron; amitrol; AMS, i.e. ammonium sulfamate; anilofos; asulam; atrazin; aziprotryn; barban; BAS 516 H, i.e. 5-fluoro-2-phenyl-4H-3,1-benzoxazin-4-one; benazolin; benfluralin; benfuresate; bensulfuron-methyl; bensulide; bentazone; benzofenap; benzofluor; benzoylprop-ethyl; benzthiazuron; bialaphos; bifenox; bromacil; bromobutide; bromofenoxim; bromoxynil; bromuron; buminafos; busoxinone; butachlor; butamifos; butenachlor; buthidazole; butralin; butylate; carbetamide; CDAA, i.e. 2-chloro-N,N-di-2-propenylacetemide; CDEC, i.e. 2-chloroallyl diethyldithiocarbamate; CGA 184927, i.e. 2- 4- (5-chloro-3-fluoro-2-pyridinyl)oxy!phenoxy!propanoic acid and its 2-propynyl ester; chlomethoxyfen; chloramben; chlorazifop-butyl; pirifenop-butyl; chlorbromuron; chlorbufam; chlorfenac; chlorflurecol-methyl; chloridazon; chlorimuron ethyl; chlornitrofen; chlorotoluron; chloroxuron; chlorpropham; chlorsulfuron; chlorthaldimethyl; chlorthiamid; cinmethylin; cinosulfuron; clethodim; clomazone; clomeprop; cloproxydim; clopyralid; cyanazine; cycloate; cycloxydim; cycluron; cyperquat; cyprazine; cyprazole; 2,4-DB; dalapon; desmediphan; desmetryn; di-allate; dicamba; dichlobenil; dichlorprop; diclofop-methyl; diethatyl; difenoxuron; difenzoquat; diflufenican; dimefuron; dimethachlor; dimethametryn; dimethazone; clomazon; dimethipin; dimetrasulfuron, cinosulfuron; dinitramine; dinoseb; dinoterb; diphenamid; dipropetryn; diquat; dithiopyr; diuron; DNOC; eglinazine-ethyl; EL 177, i.e. 5-cyano-1-(1,1-dimethylethyl)-N-methyl-3H-pyrazole-4-carboxamide; endothal; EPTC; esprocarb; ethafluralin; ethametsulfuron-methyl; ethidimuron; ethiozin; ethofumesate; F5231, i.e. N- 2-chloro-4-fluoro-5- 4-(3-fluoropropyl)-4,5-dihydro-5-oxo-1H-tetrazol-1-yl!phenyl!ethanesulfonamide; F6285, i.e. 1- 5-(N-methylsulfonyl)amino-2,4-dichlorophenyl!-3-methyl-4-difluoromethyl-1,2,4-triazol-5-one; fenoprop; fenoxan, s. clomazon; fenoxaprop-ethyl; fenuron; flamprop-methyl; flazasulfuron; fluazifop and its ester derivatives; fluchloralin; flumetsulam; N- 2,6-difluorophenyl!-5-methyl-1,2,4-triazolo 1,5a!pyrimidin-2-sulfonamide; flumeturon; flumipropyn; fluorodifen; fluoroglycofen-ethyl; fluridone; flurochloridone; fluroxypyr; flurtamone; fomesafen; fosamine; furyloxyfen; glufosinate; glyphosate; halosaten; haloxyfop and its ester derivatives; hexazinone; Hw 52, i.e. N-(2,3-dichlorophenyl)-4-(ethoxymethoxy)benzamide; imazamethabenzmethyl; imazapyr; imazaquin; imazethamethapyr; imazethapyr; imazosulfuron; ioxynil; isocarbamid; isopropalin; isoproturon; isouron; isoxaben; isoxapyrifop; karbutilate; lactofen; lenacil; linuron; MCPA; MCPB; mecoprop; mefenacet; mefluidid; metamitron; metazachlor; methabenzthiazuron; metham; methazole; methoxyphenone; methenyldymron; metobromuron; metolachlor; metoxuron; metribuzin; metsulfuron-methyl; MH; molinate; monalide; monocarbamide dihydrogensulfate; monolinuron; monuron; MT 128, i.e. 6-chloro-N-(3-chloro-2-propenyl)-5-methyl-N-phenyl-3-pyridazinamine; MT 5950, i.e. N- 3-chloro-4-(1-methylethyl)phenyl!-2-methylpentanamide; naproanilide; napropamide; naptalam; NC 310, i.e. 4-(2,4-dichlorobenzoyl)-1-methyl-5-benzloxypyrazole; neburon; nicosulfuron; nipyraclophen; nitralin; nitrofen; nitrofluorfen; norflurazon; orbencarb; oryzalin; oxadiazon; oxyfluorfen; paraquat; pebulate; pendimethalin; perfluidone; phenisopham; phenmedipham; picloram; piperophos; piributicarb; pirifenop-butyl; pretilachlor; primisulfuron-methyl; procyazine; prodiamine; profluralin; proglinazine-ethyl; prometon; prometryn; propachlor; propanil; propaquizafop and its ester derivatives; propazine; propham; propyzamide; prosulfalin; prosulfocarb; prynachlor; pyrazolinate; pyrazon; pyrazosulfuron-ethyl; pyrazoxyfen; pyridate; quinclorac; quinmerac; quinofop and its ester derivatives, quizalofop and its ester derivatives; quizalofop-ethyl; quizalofop-p-tefuryl; renriduron; dymron; S 275, i.e. 2- 4-chloro-2-fluoro-5-(2-propynyloxy)phenyl!-4,5,6,7-tetrahydro-2H-indazole; S 482, i.e. 2- 7-fluoro-3,4-dihydro-3-oxo-4-(2-propynyl)-2H-1,4-benzoxazin-6-yl!-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione; secbumeton; sethoxydim; siduron; simazine; simetryn; SN 106279, i.e. 2- 7- 2-chloro-4-(trifluoromethyl)phenoxy!-2-naphthyl!oxy!propanoic acid and its methyl ester; sulfometuron-methyl; sulfazuron; flazasulfuron; TCA; tebutam; tebuthiuron; terbacil; terbucarb; terbuchlor; terbumeton; terbuthylazine; terbutryn; TFH 450, i.e. N,N-diethyl-3- (2-ethyl-6-methylphenyl)sulfonyl!-1H-1,2,4-triazole-1-carboxamide; thiazafluoron; thifensulfuron-methyl; thiobencarb; tiocarbazil; tralkoxydim; tri-allate; triasulfuron; triazofenamide; tribenuron-methyl; triclopyr; tridiphane; trietazine; trifluralin; trimeturon; vernolate; WL 110547, i.e. 5-phenoxy-1- 3-(trifluoromethyl)phenyl!-1H-tetrazole.

For use, the formulations, present in commercially available form, are diluted, if appropriate, in a customary manner, for example using water in the case of wettable powders, emulsifiable concentrates, dispersions and water-dispersible granules and then applied to plants, plant parts or agriculturally or industrially utilized soil, on which the plants are located, or in which they grow or are present as seed. Preparations in the form of dusts or granules for soil application and scattering, and also sprayable solutions, are usually not further diluted with other inert substances before use.

The application rate required for the compounds of the formula I varies with the external conditions, such as, inter alia, temperature, humidity, and the nature of the herbicide used. It can vary within wide limits, for example between 0.001 and 10.0 kg/ha or more of active substance; preferably, however, it is between 0.005 and 5 kg/ha.

A) CHEMICAL EXAMPLES a) 2-Carboxy-nitrobenzenesulfonic acid

400.0 g (2.53 mol) of potassium permanganate are added in portions at 80° C. over a period of 2 h to a solution of 106.0 g (0.40 mol) of 2-methyl-5-nitrobenzenesulfonic acid and 80.0 g (0.58 mol) of potassium carbonate in 1300 ml of water. The reaction temperature is maintained at between 80° and 95° C.

After stirring for a further 4 h, the solid formed is filtered off. The filtrate is acidified with concentrated hydrochloric acid (pH=1). The colorless 2-carboxy-5-nitrobenzenesulfonic acid which has precipitated is filtered off with suction through a Buchner funnel and dried at about 50° C./100 torr (82.0 g; 83.7% of theory). Melting point: >300° C.

b) 2-Methoxycarboxy-5-nitrobenzenesulfonic acid

A suspension of 190.0 g (0.77 mol) of 2-carboxy-5-nitrobenzenesulfonic acid, 10 ml of DMF and 250 ml (3.43 mol) of thionyl chloride is heated at boiling for 3 h. After separating off the insoluble constituents by filtration, the filtrate is concentrated. 200 ml (4.94 mol) of methanol are added to the residue which results. When addition is complete the reaction mixture is cooled to 0° C. The solid which precipitates is filtered off and dried. 70.9 g (35.3% of theory) of colorless, crystalline 2-methoxycarbonyl-5-nitrobenzenesulfonic acid (m.p.: 92°-94° C.) are thus obtained. By distilling off the volatile components from the mother liquor, a second fraction (62.5 g, 31.1% of theory) is obtained.

c) 2-Methoxycarbonyl-5-nitrobenzenesulfonyl chloride

A solution of 17.3 g (0.27 mol) of potassium hydroxide (88% strength) and 100 ml of methanol is added carefully with vigorous stirring to a solution of 70.9 g (0.27 mol) of 2-methoxycarbonyl-5-nitrobenzenesulfonic acid in 300 ml of methanol. The mixture is cooled to 0° C. and the salt which is precipitated is filtered off, dried and then suspended in 150 ml of sulfolane, 150 ml of acetonitrile and 10 ml of dimethylformamide. After the dropwise addition of 100 ml (1.07 mol) of phosphorus oxychloride, the mixture is heated at boiling for 2.5 h. The reaction mixture is then poured into ice-water. The 2-methoxycarbonyl-5-nitrobenzenesulfonyl chloride (60.1 g, 70% of theory) which has precipitated is filtered off with suction through a Buchner funnel and freed from traces of solvent under reduced pressure. Melting point: 86°-88° C.

d) N-tert-Butyl-2-methoxycarbonyl-5-nitrobenzenesulfonamide

50 ml (0.48 mol) of tert-butylamine are slowly added dropwise at 0° C. to a solution of 34.4 g (0.12 mol) of 2-methoxycarbonyl-5-nitrobenzenesulfonyl chloride in 200 ml of ethyl acetate and 250 ml of ethanol. The reaction solution is then stirred for a further 10 min at room temperature. After the addition of 500 ml of water, a colorless solid crystallizes out. It is filtered off and dried to give 28.1 g (89% of theory) of N-tert-butyl-2-methoxycarbonyl-5-nitrobenzenesulfonyl chloride. m.p.: 121°-124° C.

e) N-tert-Butyl-5-amino-2-methoxycarbonylbenzenesulfonamide

25.08 g (0.079 mol) of N-tert-butyl-2-methoxycarbonyl-5-nitrobenzenesulfonamide are dissolved in 1000 ml of MeOH. 0.50 g of Pd--C (10%) is added and the mixture is shaken under a hydrogen atmosphere (1 atm) until the uptake of hydrogen has finished. The catalyst is separated off and the solvent is removed by distillation. The residue is induced to crystallize by stirring with a little ethyl acetate. The resulting N-tert-butyl-5-amino-2-methoxycarbonylbenzenesulfonamide (18.3 g; 80.9% of theory) melts at 193° C.

f) N-tert-Butyl-5-formylamino-2-methoxycarbonylbenzenesulfonamide

6.5 ml of formic acid are carefully added at 0° C. to 13 ml of acetic anhydride. The mixture is subsequently heated at 50°-60° C. for 2 h. A solution of 16.0 g (0.056 mol) of N-tert-butyl-5-amino-2-methoxycarbonylbenzenesulfonamide in 50 ml of DMF is then added dropwise at 0° C. The cooling bath is removed and the mixture is stirred for a further 4 h at room temperature. The reaction mixture is then shaken up in 800 ml of ethyl acetate and washed with three times 150 ml of water. The organic phase is dried over magnesium sulfate, the solvent is distilled off, and the residue is recrystallized from ethyl acetate/n-heptane. The product is N-tert-butyl-5-formylamino-2-methoxycarbonylbenzenesulfonamide (14.23 g, 82% of theory) which melts at 113°-114° C.

g) N-tert-Butyl-2-methoxycarybonyl-5-methylaminobenzenesulfonamide

9.92 g (0.032 mol) of N-tert-butyl-5-formylamino-2-methoxycarbonylbenzenesulfonamide are dissolved in 50 ml of CHCl₃, and then 5 ml (0.053 mol) of boranedimethyl sulfide complex are added at 0° C. After 1 h at 0° C. and 3 h at room temperature the reaction mixture is cooled to 0° C. 30 ml of methanol are added and the mixture is washed with water. The organic phase is dried over magnesium sulfate, the solvent is removed by distillation, and 9.23 g (98% of theory) of N-tert-butyl-2-methoxycarbonyl-5-methylaminobenzenesulfonamide are obtained. m.p.: 120°-124° C.

h) N-tert-Butyl-5- N-(ethoxycarbonylaminothiocarbonyl)methylamino!-2-methoxyrcarbonylbenzenesulfonamide

1.20 g (4.0 mmol) of N-tert-butyl-2-methoxycarbonyl-5-methylaminobenzenesulfonamide is dissolved in 5 ml of anhydrous DMF, and 0.60 g (4.3 mmol) of 95% strength ethoxycarbonyl isothiocyanate is added. After 3 h at room temperature the mixture is taken up in ethyl acetate and washed with 1N hydrochloric acid and water. The organic phase is dried over magnesium sulfate and the solvent is removed by distillation. The residue is taken up in a little ethyl acetate and precipitated with heptane at -25° C. The precipitate is filtered off with suction and dried to give 1.29 g (75% of theory) of colorless N-tert-butyl-5- N-(ethoxycarbonylaminothiocarbonyl)methylamino!-2-methoxycarbonylbenzenesulfonamide. m.p.: 110° C.

i) 5- N-(Ethoxycarbonylaminothiocarbonyl)methylamino!-2-methoxycarbonylbenzenesulfonamide

1.05 g (2.4 mmol) of N-tert-butyl-5- N-(ethoxycarbonylaminothiocarbonyl)methylamino!-2-methoxycarbonylbenzenesulfonamide is stirred for 18 h in 15 ml of trifluoroacetic acid at room temperature. Volatile components are then removed by distillation at 12 torr/50° C. The residue is suspended in toluene. The suspension is again concentrated at 12 torr/50° C. to give a highly viscous residue (0.85 g, 93% of theory) which is reacted directly without further purification to give the corresponding sulfonylurea (cf. Example j).

j) N- (4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl!-5- N-(ethoxycarbonylaminothiocarbonyl)methyamino!-2-methoxycarbonylbenzenesulfonamide (see tabular Example 2192)

1.2 ml of DBU is added to a suspension of 0.69 g (1.84 mol) of 5- N-(ethoxycarbonylaminothiocarbonyl)methylamino!-2-methoxycarbonylbenzenesulfonamide and 0.55 g (1.99 mmol) of 4,6-dimethoxy-2-phenoxycarbonylaminopryimidine in 5 ml of acetonitrile. The mixture is stirred for 17 h at room temperature and the solvent is then removed by distillation. The residue is taken up in water and washed with diethyl ether. The aqueous phase is acidified with concentrated hydrochloric acid (pH=1) and produces a colorless precipitate, which is filtered off and induced to crystallize by stirring with a little methanol. The resulting product is 0.61 g (60% of theory) of N- (4,6-dimethoxypyrimidin-2-yl)aminocarbonyl!-5- N-(ethoxycarbonylaminothiocarbonyl)methylamino!-2-methoxycarbonylbenzenesulfonamide. m.p.: 144°-145° C.

k) 5- N-(Acetylmethylamino)-N-(4,6-dimethoxypryrimidin-2-yl)aminocarbonyl!-2-methoxycarbonylbenzenesulfonamide (see Table 1, Example 89)

0.45 ml of DBU is added to a mixture of 0.75 g (2.6 mmol) of 5-(N-acetylmethylamino)-2-methoxycarbonylbenzenesulfonamide and 0.73 g (2.6 mmol) of 4,6-dimethoxy-2-(phenoxycarbonylamino)pyrimidine in 10 ml of CH₃ CN. The mixture is worked up in analogy to Example j) to give 0.59 g of the desired sulfonylurea, m.p.: 197° C.

l) 2-Methoxycarbonyl-5-(N-methoxycarbonyl-N-methylamino)benzenesulfonyl isocyanate

5.0 g of 2-methoxycarbonyl-5-(N-methoxycarbonyl-N-methylamino)benzenesulfonamide are suspended in 17 ml of 1,2-dichloroethane. 4 ml of thionyl chloride are added and the reaction mixture is heated at boiling for 5 h.

The reaction mixture is cooled to room temperature, 0.3 ml of pyridine is added, phosgene is passed into the reaction mixture, and the solution is heated at reflux for 4 h. The reaction mixture is concentrated to give 6.3 g of an oil which is employed directly in the subsequent reaction (Examples m, n, o).

m) 2-Methoxycarbonyl-5-(N-methoxycarbonyl-N-methylamino)-N- (4,6-dimethylpyrimidin-2-yl)aminocarbonyl!benzenesulfonamide (see Table 1, Example 1,183)

A solution of 2.1 g of 2-methoxycarbonyl-5-(N-methoxycarbonylmethylamino)benzenesulfonyl isocyanate (Example 1)) in 20 ml of dichloroethane is added to a solution of 0.8 g of 2-amino-4,6-dimethylpyrimidine in 20 ml of dichloroethane. The reaction mixture is stirred for 8 h at 40° C. and then concentrated. The residue is induced to form the product by stirring intensively and successively with 1N hydrochloric acid and methanol, to give 0.47 g of the desired sulfonylurea as a solid foam:

hu 1H NMR (DMSO, 80 MHz); δ (ppm)=2.5 (s, 6H, 2 CH₃), 3.3 (s, 3H, N--CH₃), 3.7 (s, 3H, O--CH₃), 3.9 (s, 3H, OCH₃), 7.0 (s, 1H, H_(pyrimidine)), 7.8 (s, 2H, 3-H and 4-H), 8.1 (s, 1H, 6-H), 10.6 (s, 1H, NH), 13.3 (s, 1H, SO₂ --NH).

n) N- (4-Chloro-6-methoxypyrimidin-2-yl)aminocarbonyl!-2-methoxycarbonyl-5-(N-methoxycarbonyl-N-methylamino)benzenesulfonamide (see Table 1, Example 1,185)

By analogy with Example m), 0.9 g of 2-amino-4-chloro-6-methoxypryrimidine is reacted with 2.1 g of 2-methoxycarbonyl-5-(N-methoxycarbonyl-N-methylamino)benzenesulfonyl isocyanate (Example 1)). Yield: 0.45 g of the desired sulfonylurea as a solid foam:

¹ H NMR (DMSO, 80 MHz): δ (ppm)=3.3 (s, 3H, N--CH₃), 3.7 (s, 3H, O--CH₃), 3.8 (s, 3H, O--CH₃), 4.0 (s, 3H, O--CH₃), 6.8 (s, 1H, H_(pyrimidine)), 7.7 (s, 2H, 3-H and 4-H), 10.9 (s, 1H, NH), 12.0 (s, 1H, SO₂ --NH).

o) N- N-(4-Methoxy-6-methyltriazin-2-yl)aminocarbonyl!-2-methoxycarbonyl-5-(N-methoxycarbonyl-N-methylamino)benzenesulfonamide (see Table 1, Example 1,180)

By analogy with Example m), 0.85 g of 2-amino-4-methoxy-6-methyltriazine is reacted with 2.1 g of 2-methoxycarbonyl-5-(N-methoxycarbonyl-N-methylamino)benzenesulfonyl isocyante (Example 1)). Yield: 0.47 g of the desired sulfonylurea as a solid foam:

¹ H NMR (DMSO, 80 MHz): δ (ppm)=2.4 (s, 3H, CH₃), 3.3 (s, 3H, N--CH₃), 3.7 (s, 3H, OCH₃), 3.8 (s, 3H, OCH₃), 4.0 (s, 3H, O--CH₃), 7.8 (s, 2H, 3-H, 4-H), 8.1 (s, 1H, 6-H), 11.0 (s, 1H, NH), 12.3 (s, 14, SO₂ NH).

The remainder of the compounds described in Table 1 are obtained in a manner analogous to Examples a) to o).

The following abbreviations are used in Table 1:

No.=Example number

m.p.=solidification point (melting point) in °C.

Me=methyl

Et=ethyl

Pr=n-propyl

n-Pr=n-propyl

i-Pr=i-propyl

c-Pr=cyclopropyl

Bu=butyl

Ph=phenyl.

                                      TABLE 1                                      __________________________________________________________________________      ##STR12##                                                                     No.                                                                               R.sup.1                                                                           R.sup.2    R.sup.3   R.sup.4                                                                           X    Y    Z m.p.                                 __________________________________________________________________________     1  Me COCH.sub.2 OMe                                                                            CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     2  Et "          "         "  "    "    "                                      3  Me COCH.sub.2 NHCO.sub.2                                                                     "         "  "    "    "                                            Me                                                                       4  Me COCH.sub.2 SMe                                                                            "         "  "    "    "                                      5  "  "          "         Me "    "    "                                      6  "  "          "         H  OMe  Me   N                                      7  "  "          "         "  Me   Me   CH                                     8  Et "          "         "  "    "    "                                      9  "  "          "         "  OMe  "    N                                      10 "  "          "         "  OMe  OMe  N                                      11 Me CHO        "         "  OMe  OMe  CH                                                                               177-182                              12 "  "          "         "  OMe  OMe  N 180-181                              13 "  "          "         "  OMe  Me   N 160-164                              14 "  "          "         "  OMe  Me   CH                                     15 "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N  93-95                               16 "  "          "         "  Me   Me   CH                                                                               161-164                              17 "  "          "         "  Me   Me   N                                      18 "  "          "         "  Cl   OMe  CH                                                                               184-186                              19 "  "          "         Me OMe  OMe  CH                                     20 "  "          "         Me OMe  Me   N                                      21 "  "          CO.sub.2 Et                                                                              H  OMe  OMe  CH                                     22 "  "          "         "  OMe  Cl   CH                                     23 "  "          "         "  Me   Me   CH                                     24 "  "          "         "  OMe  Me   N                                      25 "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      26 "  "          "         Me OMe  OMe  CH                                     27 "  "          "         Me OMe  Me   N                                      28 "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     29 "  "          "         "  OMe  OMe  N                                      30 "  "          "         "  OMe  Me   N                                      31 "  "          "         "  Me   Me   CH                                     32 "  "          "         "  OMe  Cl   CH                                     33 "  "          "         Me Me   OMe  N                                      34 "  "          "         Me OMe  OMe  CH                                     35 Me CHO        CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     36 "  "          "         "  OMe  OMe  N                                      37 "  "          "         "  OMe  Me   N                                      38 "  "          "         "  OMe  Cl   CH                                     39 "  "          "         "  Me   Me   CH                                     40 "  "          "         "  SMe  NEt.sub.2                                                                           N                                      41 "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      42 "  "          "         Me OMe  OMe  CH                                     43 Me CHO        CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     44 Et CHO        CO.sub.2 Me                                                                              H  OMe  OMe  CH                                                                               161-163                              45 "  "          "         "  OMe  Me   N                                      46 "  "          "         "  Me   Me   CH                                     47 "  "          "         "  Cl   OMe  CH                                     48 "  "          "         Me OMe  OMe  CH                                     49 "  "          "         Me OMe  Me   N                                      50 "  "          CO.sub.2 Et                                                                              H  OMe  OMe  CH                                     51 "  "          "         "  OMe  Me   CH                                     52 "  "          "         "  Cl   OMe  CH                                     53 "  "          "         "  OMe  Me   N                                      54 "  "          "         Me OMe  OMe  CH                                     55 "  "          "         Me OMe  Me   N                                      56 "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     57 "  "          "         "  OMe  Me   N                                      58 "  "          "         "  OMe  Cl   CH                                     59 "  "          "         "  Me   Me   CH                                     60 "  "          "         Me OMe  OMe  CH                                     61 "  "          "         Me OMe  Me   N                                      62 "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     63 "  "          "         "  OMe  Me   N                                      64 "  "          "         "  Me   Me   CH                                     65 "  "          "         Me OMe  Me   N                                      66 n-Pr                                                                              CHO        CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     67 "  "          "         "  OMe  Cl   CH                                     68 "  "          "         "  Me   Me   CH                                     69 "  "          "         "  OMe  Me   N                                      70 "  "          "         Me OMe  OMe  CH                                     71 "  "          "         Me OMe  Me   N                                      72 n-Pr                                                                              "          CO.sub.2 Et                                                                              H  OMe  Me   N                                      73 "  "          "         "  OMe  OMe  CH                                     74 "  "          "         "  Me   Me   CH                                     75 "  "          CO.sub.2 n-Pr                                                                            "  OMe  OMe  CH                                     76 i-Pr                                                                              "          CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     77 "  "          "         "  OMe  Me   N                                      78 "  "          "         "  Me   Me   CH                                     79 "  "          "         "  Cl   OMe  N                                      80 "  "          "         Me OMe  Me   N                                      81 "  "          "         Me OMe  OMe  CH                                     82 Allyl                                                                             "          CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     83 "  "          "         "  OMe  Cl   CH                                     84 "  "          "         "  Me   Me   CH                                     85 "  "          "         "  OMe  Me   N                                      86 "  "          CO.sub.2 Et                                                                              "  OMe  OMe  CH                                     87 "  "          CO.sub.2 n-Pr                                                                            "  OMe  OMe  CH                                     88 "  "          CO.sub.2 i-Pr                                                                            "  OMe  OMe  CH                                     89 Me COCH.sub.3 CO.sub.2 Me                                                                              "  OMe  OMe  CH                                                                               197° C.                       90 "  "          "         "  OMe  OMe  N 198-200                              91 "  "          "         "  OMe  Me   N 191-193                              92 "  "          "         "  OMe  Me   CH                                                                               204                                  93 "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N 115-118                              94 "  "          "         "  Me   Me   CH                                                                               192-193                              95 "  "          "         "  Me   Me   N                                      96 "  "          "         "  Cl   OMe  CH                                                                               191-193                              97 "  "          "         Me OMe  OMe  CH                                     98 "  "          "         Me OMe  Me   N                                      99 "  "          CO.sub.2 Et                                                                              H  OMe  OMe  CH                                     100                                                                               "  "          "         "  OMe  Cl   CH                                     101                                                                               "  "          "         "  Me   Me   CH                                     102                                                                               "  "          "         "  OMe  Me   N                                      103                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      104                                                                               "  "          "         Me OMe  OMe  CH                                     105                                                                               "  "          "         Me OMe  Me   N                                      106                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     107                                                                               "  "          "         "  OMe  OMe  N                                      108                                                                               "  "          "         "  OMe  Me   N                                      109                                                                               "  "          "         "  Me   Me   CH                                     110                                                                               "  "          "         "  OMe  Cl   CH                                     111                                                                               "  "          "         Me Me   OMe  N                                      112                                                                               "  "          "         Me OMe  OMe  CH                                     113                                                                               Me COCH.sub.3 CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     114                                                                               "  "          "         "  OMe  OMe  N                                      115                                                                               "  "          "         "  OMe  Me   N                                      116                                                                               "  "          "         "  OMe  Cl   CH                                     117                                                                               "  "          "         "  Me   Me   CH                                     118                                                                               "  "          "         "  SMe  NEt.sub.2                                                                           N                                      119                                                                               "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      120                                                                               "  "          "         Me OMe  OMe  CH                                     121                                                                               Me COCH.sub.3 CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     122                                                                               Et "          CO.sub.2 Me                                                                              H  OMe  OMe  CH                                                                               126-129                              123                                                                               "  "          "         "  OMe  Me   N                                      124                                                                               "  "          "         "  Me   Me   CH                                     125                                                                               "  "          "         "  Cl   OMe  CH                                     126                                                                               "  "          "         Me OMe  OMe  CH                                     127                                                                               "  "          "         Me OMe  Me   N                                      128                                                                               "  "          CO.sub.2 Et                                                                              H  OMe  OMe  CH                                     129                                                                               "  "          "         "  OMe  Me   CH                                     130                                                                               "  "          "         "  Cl   OMe  CH                                     131                                                                               "  "          "         "  OMe  Me   N                                      132                                                                               "  "          "         Me OMe  OMe  CH                                     133                                                                               "  "          "         Me OMe  Me   N                                      134                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     135                                                                               "  "          "         "  OMe  Me   N                                      136                                                                               "  "          "         "  OMe  Cl   CH                                     137                                                                               "  "          "         "  Me   Me   CH                                     138                                                                               "  "          "         Me OMe  OMe  CH                                     139                                                                               "  "          "         Me OMe  Me   N                                      140                                                                               "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     141                                                                               "  "          "         "  OMe  Me   N                                      142                                                                               "  "          "         "  Me   Me   CH                                     143                                                                               "  "          "         Me OMe  Me   N                                      144                                                                               n-Pr                                                                              COCH.sub.3 CO.sub.2 Me                                                                              H  OMe  OMe  CH                                                                               160° C.                       145                                                                               "  "          "         "  OMe  Cl   CH                                     146                                                                               "  "          "         "  Me   Me   CH                                     147                                                                               "  "          "         "  OMe  Me   N                                      148                                                                               "  "          "         Me OMe  OMe  CH                                     149                                                                               "  "          "         Me OMe  Me   N                                      150                                                                               n-Pr                                                                              "          CO.sub.2 Et                                                                              H  OMe  Me   N                                      151                                                                               "  "          "         "  OMe  OMe  CH                                     152                                                                               "  "          "         "  Me   Me   CH                                     153                                                                               "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     154                                                                               i-Pr                                                                              "          CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     155                                                                               "  "          "         "  OMe  Me   N                                      156                                                                               "  "          "         "  Me   Me   CH                                     157                                                                               "  "          "         "  Cl   OMe  N                                      158                                                                               "  "          "         Me OMe  Me   N                                      159                                                                               "  "          "         Me OMe  OMe  CH                                     160                                                                               Allyl                                                                             "          CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     161                                                                               "  "          "         "  OMe  Cl   CH                                     162                                                                               "  "          "         "  Me   Me   CH                                     163                                                                               "  "          "         "  OMe  Me   N                                      164                                                                               "  "          CO.sub.2 Et                                                                              H  OMe  OMe  CH                                     165                                                                               "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     166                                                                               "  "          CO.sub.2 -i-Pr                                                                           "  OMe  OMe  CH                                     167                                                                               Me COCH.sub.2 CH.sub.3                                                                       CO.sub.2 Me                                                                              H  OMe  OMe  CH                                                                               186-188                              168                                                                               "  "          "         "  OMe  OMe  N                                      169                                                                               "  "          "         "  SMe  Me   N                                      170                                                                               "  "          "         "  OMe  Me   N 174-176                              171                                                                               "  "          "         "  OMe  Me   CH                                     172                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      173                                                                               "  "          "         "  Me   Me   CH                                                                               161-164                              174                                                                               "  "          "         "  Me   Me   N                                      175                                                                               "  "          "         "  Cl   OMe  CH                                                                               149-152                              176                                                                               "  "          "         Me OMe  OMe  CH                                     177                                                                               "  "          CO.sub.2 Me                                                                              Me OMe  Me   N                                      178                                                                               "  "          CO.sub.2 Et                                                                              H  OMe  OMe  CH                                     179                                                                               "  "          "         "  OMe  Cl   CH                                     180                                                                               "  "          "         "  Me   Me   CH                                     181                                                                               "  "          "         "  OMe  Me   N                                      182                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      183                                                                               "  "          "         Me OMe  OMe  CH                                     184                                                                               "  "          "         Me OMe  Me   N                                      185                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     186                                                                               "  "          "         "  OMe  OMe  N                                      187                                                                               "  "          "         "  OMe  Me   N                                      188                                                                               "  "          "         "  Me   Me   CH                                     189                                                                               "  "          "         "  OMe  Cl   CH                                     190                                                                               "  "          "         Me Me   OMe  N                                      191                                                                               "  "          "         "  OMe  OMe  CH                                     192                                                                               Me COCH.sub.2 CH.sub.3                                                                       CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     193                                                                               "  "          "         "  OMe  OMe  N                                      194                                                                               "  "          "         "  OMe  Me   N                                      195                                                                               "  "          "         "  OMe  Cl   CH                                     196                                                                               "  "          "         "  Me   Me   CH                                     197                                                                               "  "          "         "  SMe  NEt.sub.2                                                                           N                                      198                                                                               "  "          "         Me OMe  Me   N                                      199                                                                               "  "          "         "  OMe  OMe  CH                                     200                                                                               Me COCH.sub.2 CH.sub.3                                                                       CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     201                                                                               Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     202                                                                               "  "          "         "  OMe  Me   N                                      203                                                                               "  "          "         "  Me   Me   CH                                     204                                                                               "  "          "         "  Cl   OMe  CH                                     205                                                                               "  "          "         Me OMe  OMe  CH                                     206                                                                               "  "          "         "  OMe  Me   N                                      207                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     208                                                                               "  "          "         "  OMe  Me   CH                                     209                                                                               "  "          "         "  Cl   OMe  CH                                     210                                                                               "  "          "         "  OMe  Me   N                                      211                                                                               "  "          "         Me OMe  OMe  CH                                     212                                                                               "  "          "         "  "    Me   N                                      213                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     214                                                                               "  "          "         "  OMe  Me   N                                      215                                                                               "  "          "         "  OMe  Cl   CH                                     216                                                                               "  "          "         "  Me   Me   CH                                     217                                                                               "  "          "         Me OMe  OMe  CH                                     218                                                                               "  "          "         "  OMe  Me   N                                      219                                                                               "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     220                                                                               "  "          "         "  OMe  Me   N                                      221                                                                               "  "          "         "  Me   Me   CH                                     222                                                                               "  "          "         Me OMe  Me   N                                      223                                                                               n-Pr                                                                              COCH.sub.2 CH.sub.3                                                                       CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     224                                                                               "  "          "         "  OMe  Cl   CH                                     225                                                                               "  "          "         "  Me   Me   CH                                     226                                                                               "  "          "         "  OMe  Me   N                                      227                                                                               "  "          "         Me OMe  OMe  CH                                     228                                                                               "  "          "         Me OMe  Me   N                                      229                                                                               n-Pr                                                                              "          CO.sub.2 Et                                                                              H  OMe  Me   N                                      230                                                                               "  "          "         "  OMe  OMe  CH                                     231                                                                               "  "          "         "  Me   Me   CH                                     232                                                                               "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     233                                                                               i-Pr                                                                              "          CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     234                                                                               "  "          "         "  OMe  Me   N                                      235                                                                               "  "          "         "  Me   Me   CH                                     236                                                                               "  "          "         "  Cl   OMe  N                                      237                                                                               "  "          "         Me OMe  Me   N                                      238                                                                               "  "          "         Me OMe  OMe  CH                                     239                                                                               Allyl                                                                             "          CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     240                                                                               "  "          "         "  OMe  Cl   CH                                     241                                                                               "  "          "         "  Me   Me   CH                                     242                                                                               "  "          "         "  OMe  Me   N                                      243                                                                               "  "          CO.sub.2 Et                                                                              H  OMe  OMe  CH                                     244                                                                               "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     245                                                                               "  "          CO.sub.2 -i-Pr                                                                           "  OMe  OMe  CH                                     246                                                                               Me CO-n-Pr    CO.sub.2 Me                                                                              H  OMe  OMe  CH                                                                               186-188                              247                                                                               "  "          "         "  OMe  OMe  N                                      248                                                                               "  "          "         "  OMe  Me   N                                      249                                                                               "  "          "         "  OMe  Me   CH                                     250                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      251                                                                               "  "          "         "  Me   Me   CH                                     252                                                                               "  "          "         "  Me   Me   N                                      253                                                                               "  "          "         "  Cl   OMe  CH                                     254                                                                               "  "          "         Me OMe  OMe  CH                                     255                                                                               "  "          "         Me OMe  Me   N                                      256                                                                               "  "          CO.sub.2 Et                                                                              H  OMe  OMe  CH                                     257                                                                               "  "          "         "  OMe  Cl   CH                                     258                                                                               "  "          "         "  Me   Me   CH                                     259                                                                               "  "          "         "  OMe  Me   N                                      260                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      261                                                                               "  "          "         Me OMe  OMe  CH                                     262                                                                               "  "          "         Me OMe  Me   N                                      263                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  N                                      264                                                                               "  "          "         "  OMe  OMe  CH                                     265                                                                               Me CO-n-Pr    CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     266                                                                               "  "          "         "  OMe  OMe  N                                      267                                                                               "  "          "         "  OMe  Cl   CH                                     268                                                                               "  "          "         Me Me   OMe  N                                      269                                                                               "  "          "         Me OMe  OMe  CH                                     270                                                                               Me CO-n-Pr    CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     271                                                                               "  "          "         "  OMe  OMe  N                                      272                                                                               "  "          "         "  OMe  Me   N                                      273                                                                               "  "          "         "  OMe  Cl   CH                                     274                                                                               "  "          "         "  Me   Me   CH                                     275                                                                               "  "          "         "  SMe  NEt.sub.2                                                                           N                                      276                                                                               "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      277                                                                               "  "          "         Me OMe  OMe  CH                                     278                                                                               Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     279                                                                               Et "          CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     280                                                                               "  "          "         "  OMe  Me   N                                      281                                                                               "  "          "         "  Me   Me   CH                                     282                                                                               "  "          "         "  Cl   OMe  CH                                     283                                                                               "  "          "         Me OMe  OMe  CH                                     284                                                                               "  "          "         Me OMe  Me   N                                      285                                                                               "  "          CO.sub.2 Et                                                                              H  OMe  OMe  CH                                     286                                                                               "  "          "         "  OMe  Me   CH                                     287                                                                               "  "          "         "  Cl   OMe  CH                                     288                                                                               "  "          "         "  OMe  Me   N                                      289                                                                               "  "          "         Me OMe  OMe  CH                                     290                                                                               "  "          "         Me OMe  Me   N                                      291                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     292                                                                               "  "          "         "  OMe  Me   N                                      293                                                                               "  "          "         "  OMe  Cl   CH                                     294                                                                               "  "          "         "  Me   Me   CH                                     295                                                                               "  "          "         Me OMe  OMe  CH                                     296                                                                               "  "          "         Me OMe  Me   N                                      297                                                                               "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     298                                                                               "  "          "         "  OMe  Me   N                                      299                                                                               n-Pr                                                                              CO-n-Pr    CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     300                                                                               "  "          "         "  OMe  Cl   CH                                     301                                                                               "  "          "         "  Me   Me   CH                                     302                                                                               "  "          "         "  OMe  Me   N                                      303                                                                               "  "          "         Me OMe  OMe  CH                                     304                                                                               "  "          "         Me OMe  Me   N                                      305                                                                               n-Pr                                                                              "          CO.sub.2 Et                                                                              H  OMe  Me   N                                      306                                                                               "  "          "         "  OMe  OMe  CH                                     307                                                                               "  "          "         "  Me   Me   CH                                     308                                                                               "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     309                                                                               i-Pr                                                                              "          CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     310                                                                               "  "          "         "  OMe  Me   N                                      311                                                                               "  "          "         "  Me   Me   CH                                     312                                                                               "  "          "         "  Cl   OMe  N                                      313                                                                               "  "          "         Me OMe  Me   N                                      314                                                                               "  "          "         Me OMe  OMe  CH                                     315                                                                               Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     316                                                                               "  "          "         "  OMe  Cl   CH                                     317                                                                               "  "          "         "  Me   Me   CH                                     318                                                                               "  "          "         "  OMe  Me   N                                      319                                                                               "  "          CO.sub.2 Et                                                                              H  OMe  OMe  CH                                     320                                                                               "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     321                                                                               "  "          CO.sub.2 -i-Pr                                                                           "  OMe  OMe  CH                                     322                                                                               Me CO-i-Pr    CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                                                               150                                  323                                                                               "  "          "         "  OMe  OMe  N                                      324                                                                               "  "          "         "  "    Me   N 165-167                              325                                                                               "  "          "         "  "    "    CH                                                                               185-187                              326                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      327                                                                               "  "          "         "  Me   Me   CH                                                                               105-110                              328                                                                               "  "          "         "  Me   Me   N                                      329                                                                               "  "          "         "  Cl   OMe  CH                                     330                                                                               "  "          "         Me OMe  OMe  CH                                     331                                                                               "  "          "         "  "    Me   N                                      332                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     333                                                                               "  "          "         "  "    Cl   CH                                     334                                                                               "  "          "         "  Me   Me   CH                                     335                                                                               "  "          "         "  OMe  Me   N                                      336                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      337                                                                               "  "          "         Me OMe  OMe  CH                                     338                                                                               "  "          "         "  OMe  Me   N                                      339                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     340                                                                               "  "          "         "  "    "    N                                      341                                                                               "  "          "         "  OMe  Me   N                                      342                                                                               "  "          "         "  Me   Me   CH                                     343                                                                               "  "          "         "  OMe  Cl   CH                                     344                                                                               "  "          "         Me Me   OMe  N                                      345                                                                               "  "          "         "  OMe  OMe  CH                                     346                                                                               Me CO-i-Pr    CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     347                                                                               "  "          "         "  "    "    N                                      348                                                                               "  "          "         "  OMe  Me   N                                      349                                                                               "  "          "         "  OMe  Cl   CH                                     350                                                                               "  "          "         "  Me   Me   CH                                     351                                                                               "  "          "         "  SMe  NEt.sub.2                                                                           N                                      352                                                                               "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      353                                                                               "  "          "         "  OMe  OMe  CH                                     354                                                                               Me COCHMe.sub.2                                                                              CH.sub.2 CHCH.sub.2                                                                      H  OMe  OMe  CH                                     355                                                                               Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     356                                                                               "  "          "         H  OMe  Me   N                                      357                                                                               "  "          "         "  Me   Me   CH                                     358                                                                               "  "          "         "  Cl   OMe  CH                                     359                                                                               "  "          "         Me OMe  OMe  CH                                     360                                                                               "  "          "         "  OMe  Me   N                                      361                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     362                                                                               "  "          "         "  OMe  Me   CH                                     363                                                                               "  "          "         "  Cl   OMe  CH                                     364                                                                               "  "          "         "  OMe  Me   N                                      365                                                                               "  "          "         Me OMe  OMe  CH                                     366                                                                               "  "          "         "  "    Me   N                                      367                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     368                                                                               "  "          "         "  OMe  Me   N                                      369                                                                               "  "          "         "  OMe  Cl   CH                                     370                                                                               "  "          "         "  Me   Me   CH                                     371                                                                               "  "          "         Me OMe  OMe  CH                                     372                                                                               "  "          "         "  OMe  Me   N                                      373                                                                               "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     374                                                                               "  "          "         "  OMe  Me   N                                      375                                                                               "  "          "         "  Me   Me   CH                                     376                                                                               "  "          "         Me OMe  Me   N                                      377                                                                               n-Pr                                                                              CO-i-Pr    CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     378                                                                               "  "          "         "  "    Cl   CH                                     379                                                                               "  "          "         "  Me   Me   CH                                     380                                                                               "  "          "         "  OMe  Me   N                                      381                                                                               "  "          "         Me OMe  OMe  CH                                     382                                                                               "  "          "         "  OMe  Me   N                                      383                                                                               n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    Me   N                                      384                                                                               "  "          "         "  "    OMe  CH                                     385                                                                               "  "          "         "  Me   Me   CH                                     386                                                                               "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     387                                                                               i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     388                                                                               "  "          "         "  OMe  Me   N                                      389                                                                               "  "          "         "  Me   Me   CH                                     390                                                                               "  "          "         "  Cl   OMe  N                                      391                                                                               "  "          "         Me OMe  Me   N                                      392                                                                               "  "          "         "  "    OMe  CH                                     393                                                                               Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     394                                                                               "  "          "         "  "    Cl   CH                                     395                                                                               "  "          "         "  Me   Me   CH                                     396                                                                               "  "          "         "  OMe  Me   N                                      397                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     398                                                                               "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     399                                                                               "  "          CO.sub.2 -i-Pr                                                                           "  "    "    "                                      400                                                                               Me CO-t-Bu    CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     401                                                                               "  "          "         "  "    OMe  N                                      402                                                                               "  "          "         "  "    Me   N                                      403                                                                               "  "          "         "  "    "    CH                                     404                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      405                                                                               "  "          "         "  Me   Me   CH                                     406                                                                               "  "          "         "  "    "    N                                      407                                                                               "  "          "         "  Cl   OMe  CH                                     408                                                                               "  "          "         Me OMe  OMe  CH                                     409                                                                               "  "          "         "  "    Me   N                                      410                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     411                                                                               "  "          "         "  "    Cl   CH                                     412                                                                               "  "          "         "  Me   Me   CH                                     413                                                                               "  "          "         "  OMe  Me   N                                      414                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      415                                                                               "  "          "         Me OMe  OMe  CH                                     416                                                                               "  "          "         "  OMe  Me   N                                      417                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     418                                                                               "  "          "         "  "    "    N                                      419                                                                               "  "          "         "  OMe  Me   N                                      420                                                                               "  "          "         "  Me   Me   CH                                     421                                                                               "  "          "         "  OMe  Cl   CH                                     422                                                                               "  "          "         Me Me   OMe  N                                      423                                                                               "  "          "         "  OMe  OMe  CH                                     424                                                                               Me CO-t-Bu    CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     425                                                                               "  "          "         "  "    "    N                                      426                                                                               "  "          "         "  H    Me   N                                      427                                                                               "  "          "         "  OMe  Cl   CH                                     428                                                                               "  "          "         "  Me   Me   CH                                     429                                                                               "  "          "         "  SMe  NEt.sub.2                                                                           N                                      430                                                                               "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      431                                                                               "  "          "         Et OMe  OMe  CH                                     432                                                                               Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     433                                                                               Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     434                                                                               "  "          "         H  OMe  Me   N                                      435                                                                               "  "          "         "  Me   Me   CH                                     436                                                                               "  "          "         "  Cl   OMe  CH                                     437                                                                               "  "          "         Me OMe  OMe  CH                                     438                                                                               "  "          "         "  OMe  Me   N                                      439                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     440                                                                               "  "          "         "  OMe  Me   CH                                     441                                                                               "  "          "         "  Cl   OMe  CH                                     442                                                                               "  "          "         "  OMe  Me   N                                      443                                                                               "  "          "         Me OMe  OMe  CH                                     444                                                                               "  "          "         "  "    Me   N                                      445                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     446                                                                               "  "          "         "  OMe  Me   N                                      447                                                                               "  "          "         "  OMe  Cl   CH                                     448                                                                               "  "          "         "  Me   Me   CH                                     449                                                                               "  "          "         Me OMe  OMe  CH                                     450                                                                               "  "          "         "  OMe  Me   N                                      451                                                                               "  "          CO.sub.2 -iPr                                                                            H  OMe  OMe  CH                                     452                                                                               "  "          "         "  OMe  Me   N                                      453                                                                               "  "          "         "  Me   Me   CH                                     454                                                                               "  "          "         Me OMe  Me   N                                      455                                                                               n-Pr                                                                              CO-t-Bu    CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     456                                                                               "  "          "         "  OMe  Cl   CH                                     457                                                                               "  "          "         "  Me   Me   CH                                     458                                                                               "  "          "         "  OMe  Me   N                                      459                                                                               "  "          "         Me OMe  OMe  CH                                     460                                                                               n-Pr                                                                              "          CO.sub.2 -Et                                                                             Me OMe  Me   N                                      461                                                                               n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  OMe  Me   N                                      462                                                                               "  "          "         "  OMe  OMe  CH                                     463                                                                               "  "          "         "  Me   Me   CH                                     464                                                                               i-Pr                                                                              "          CO.sub.2 -Me                                                                             "  OMe  OMe  CH                                     465                                                                               i-Pr                                                                              "          "         Me OMe  OMe  CH                                     466                                                                               "  "          "         H  OMe  Me   N                                      467                                                                               "  "          "         "  Me   Me   CH                                     468                                                                               "  "          "         "  Cl   OMe  N                                      469                                                                               "  "          "         Me OMe  Me   N                                      470                                                                               Allyl                                                                             "          "         H  OMe  OMe  CH                                     471                                                                               "  "          "         H  OMe  Cl   CH                                     472                                                                               "  "          "         "  OMe  Me   N                                      473                                                                               "  "          "         "  Me   Me   CH                                     474                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     475                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     476                                                                               "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     477                                                                               Me CO-c-Propyl                                                                               CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                                                               161° C                        478                                                                               "  "          "         "  "    OMe  N                                      479                                                                               "  "          "         "  "    Me   N                                      480                                                                               "  "          "         "  "    "    CH                                     481                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      482                                                                               "  "          "         "  Me   Me   CH                                     483                                                                               "  "          "         "  "    "    N                                      484                                                                               "  "          "         "  Cl   OMe  CH                                     485                                                                               "  "          "         Me OMe  OMe  CH                                     486                                                                               "  "          "         "  "    Me   N                                      487                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     488                                                                               "  "          "         "  "    Cl   CH                                     489                                                                               "  "          "         "  Me   Me   CH                                     490                                                                               "  "          "         "  OMe  Me   N                                      491                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      492                                                                               "  "          "         Me OMe  OMe  CH                                     493                                                                               "  "          "         "  OMe  Me   N                                      494                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     495                                                                               "  "          "         "  "    "    N                                      496                                                                               "  "          "         "  OMe  Me   N                                      497                                                                               "  "          "         "  Me   Me   CH                                     498                                                                               "  "          "         "  OMe  Cl   CH                                     499                                                                               "  "          "         Me Me   OMe  N                                      500                                                                               "  "          "         "  OMe  OMe  CH                                     501                                                                               Me CO-c-Propyl                                                                               CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     502                                                                               "  "          "         "  "    "    N                                      503                                                                               "  "          "         "  OMe  Me   N                                      504                                                                               "  "          "         "  OMe  Cl   CH                                     505                                                                               "  "          "         "  Me   Me   CH                                     506                                                                               "  "          "         "  SMe  NEt.sub.2                                                                           N                                      507                                                                               "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      508                                                                               "  "          "         "  OMe  OMe  CH                                     509                                                                               Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     510                                                                               Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     511                                                                               "  "          "         H  OMe  Me   N                                      512                                                                               "  "          "         "  Me   Me   CH                                     513                                                                               "  "          "         "  Cl   OMe  CH                                     514                                                                               "  "          "         Me OMe  OMe  CH                                     515                                                                               "  "          "         "  OMe  Me   N                                      516                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     517                                                                               "  "          "         "  Me   Me   CH                                     518                                                                               "  "          "         "  Cl   OMe  CH                                     519                                                                               "  "          "         "  OMe  Me   N                                      520                                                                               "  "          "         Me OMe  OMe  CH                                     521                                                                               "  "          "         "  "    Me   N                                      522                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     523                                                                               "  "          "         "  OMe  Me   N                                      524                                                                               "  "          "         "  OMe  Cl   CH                                     525                                                                               "  "          "         "  Me   Me   CH                                     526                                                                               "  "          "         Me OMe  OMe  CH                                     527                                                                               "  "          "         "  OMe  Me   N                                      528                                                                               "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     529                                                                               "  "          "         "  OMe  Me   N                                      530                                                                               "  "          "         "  Me   Me   CH                                     531                                                                               "  "          "         Me OMe  Me   N                                      532                                                                               n-Pr                                                                              CO-c-Propyl                                                                               CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     533                                                                               "  "          "         "  "    Cl   CH                                     534                                                                               "  "          "         "  Me   Me   CH                                     535                                                                               "  "          "         "  OMe  Me   N                                      536                                                                               "  "          "         Me OMe  OMe  CH                                     537                                                                               "  "          "         "  OMe  Me   N                                      538                                                                               n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      539                                                                               "  "          "         "  "    OMe  CH                                     540                                                                               "  "          "         "  Me   Me   CH                                     541                                                                               "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     542                                                                               i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     543                                                                               "  "          "         "  OMe  Me   N                                      544                                                                               "  "          "         "  Me   Me   CH                                     545                                                                               "  "          "         "  Cl   OMe  N                                      546                                                                               "  "          "         Me OMe  Me   N                                      547                                                                               "  "          "         "  "    OMe  CH                                     548                                                                               Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     549                                                                               "  "          "         "  "    Cl   CH                                     550                                                                               "  "          "         "  Me   Me   CH                                     551                                                                               "  "          "         "  OMe  Me   N                                      552                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     553                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     554                                                                               "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     555                                                                               Me CO-n-C.sub.5 H.sub.11                                                                     CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                                                               191-192                              556                                                                               "  "          "         "  OMe  OMe  N                                      557                                                                               "  "          "         "  "    Me   N                                      558                                                                               "  "          "         "  "    "    CH                                     559                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      560                                                                               "  "          "         "  Me   Me   CH                                     561                                                                               "  "          "         "  "    "    N                                      562                                                                               "  "          "         "  Cl   OMe  CH                                     563                                                                               "  "          "         Me OMe  OMe  CH                                     564                                                                               "  "          "         "  "    Me   N                                      565                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     566                                                                               "  "          "         "  "    Cl   CH                                     567                                                                               "  "          "         "  Me   Me   CH                                     568                                                                               "  "          "         "  OMe  Me   N                                      569                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      570                                                                               "  "          "         Me OMe  OMe  CH                                     571                                                                               "  "          "         "  OMe  Me   N                                      572                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     573                                                                               "  "          "         "  "    "    N                                      574                                                                               "  "          "         "  OMe  Me   N                                      575                                                                               "  "          "         "  Me   Me   CH                                     576                                                                               "  "          "         "  OMe  Cl   CH                                     577                                                                               "  "          "         Me Me   OMe  N                                      578                                                                               "  "          "         "  OMe  OMe  CH                                     579                                                                               Me CO-n-C.sub.5 H.sub.11                                                                     CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     580                                                                               "  "          "         "  "    "    N                                      581                                                                               "  "          "         "  H    Me   N                                      582                                                                               "  "          "         "  OMe  Cl   CH                                     583                                                                               "  "          "         "  Me   Me   CH                                     584                                                                               "  "          "         "  SMe  NEt.sub.2                                                                           N                                      585                                                                               "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      586                                                                               "  "          "         "  OMe  OMe  CH                                     587                                                                               Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     588                                                                               Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     589                                                                               "  "          "         H  OMe  Me   N                                      590                                                                               "  "          "         "  Me   Me   CH                                     591                                                                               "  "          "         "  Cl   OMe  CH                                     592                                                                               "  "          "         Me OMe  OMe  CH                                     593                                                                               "  "          "         "  OMe  Me   N                                      594                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     595                                                                               "  "          "         "  OMe  Me   CH                                     596                                                                               "  "          "         "  Cl   OMe  CH                                     597                                                                               "  "          "         "  OMe  Me   N                                      598                                                                               "  "          "         Me OMe  OMe  CH                                     599                                                                               "  "          "         "  "    Me   N                                      600                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     601                                                                               "  "          "         "  OMe  Me   N                                      602                                                                               "  "          "         "  OMe  Cl   CH                                     603                                                                               "  "          "         "  Me   Me   CH                                     604                                                                               "  "          "         Me OMe  OMe  CH                                     605                                                                               "  "          "         "  OMe  Me   N                                      606                                                                               "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     607                                                                               "  "          "         "  OMe  Me   N                                      608                                                                               "  "          "         "  Me   Me   CH                                     609                                                                               "  "          "         Me OMe  Me   N                                      610                                                                               n-Pr                                                                              CO-n-C.sub.5 H.sub.11                                                                     CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     611                                                                               "  "          "         "  "    Cl   CH                                     612                                                                               "  "          "         "  Me   Me   CH                                     613                                                                               "  "          "         "  OMe  Me   N                                      614                                                                               "  "          "         Me OMe  OMe  CH                                     615                                                                               "  "          "         "  OMe  Me   N                                      616                                                                               n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  OMe  Me   N                                      617                                                                               "  "          "         "  "    OMe  CH                                     618                                                                               "  "          "         "  Me   Me   CH                                     619                                                                               "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     620                                                                               i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     621                                                                               "  "          "         "  OMe  Me   N                                      622                                                                               "  "          "         "  Me   Me   CH                                     623                                                                               "  "          "         "  Cl   OMe  N                                      624                                                                               "  "          "            Me   OMe  N                                      625                                                                               "  "          "         "  "    OMe  CH                                     626                                                                               Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     627                                                                               "  "          "         "  "    Cl   CH                                     628                                                                               "  "          "         "  Me   Me   CH                                     629                                                                               "  "          "         "  OMe  Me   N                                      630                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     631                                                                               "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     632                                                                               "  "          CO.sub.2 -i-Pr                                                                           "  "    "    "                                      633                                                                               Me COCHMeEt   CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     634                                                                               "  "          "         "  "    OMe  N                                      635                                                                               "  "          "         "  "    Me   N                                      636                                                                               "  "          "         "  "    "    CH                                     637                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      638                                                                               "  "          "         "  Me   Me   CH                                     639                                                                               "  "          "         "  "    "    N                                      640                                                                               "  "          "         "  Cl   OMe  CH                                     641                                                                               "  "          "         Me OMe  OMe  CH                                     642                                                                               "  "          "         "  "    Me   N                                      643                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     644                                                                               "  "          "         "  "    Cl   CH                                     645                                                                               "  "          "         "  Me   Me   CH                                     646                                                                               "  "          "         "  OMe  Me   N                                      647                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      648                                                                               "  "          "         Me OMe  OMe  CH                                     649                                                                               "  "          "         "  OMe  Me   N                                      650                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     651                                                                               "  "          "         "  "    "    N                                      652                                                                               "  "          "         "  OMe  Me   N                                      653                                                                               "  "          "         "  Me   Me   CH                                     654                                                                               "  "          "         "  OMe  Cl   CH                                     655                                                                               "  "          "         Me Me   OMe  N                                      656                                                                               "  "          "         "  OMe  OMe  CH                                     657                                                                               Me COCHMeEt   CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     658                                                                               "  "          "         "  "    "    N                                      659                                                                               "  "          "         "  OMe  Me   N                                      660                                                                               "  "          "         "  OMe  Cl   CH                                     661                                                                               "  "          "         "  Me   Me   CH                                     662                                                                               "  "          "         "  SMe  NEt.sub.2                                                                           N                                      663                                                                               "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      664                                                                               "  "          "         "  OMe  OMe  CH                                     665                                                                               Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     666                                                                               Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     667                                                                               "  "          "         H  OMe  Me   N                                      668                                                                               "  "          "         "  Me   Me   CH                                     669                                                                               "  "          "         "  Cl   OMe  CH                                     670                                                                               "  "          "         Me OMe  OMe  CH                                     671                                                                               "  "          "         "  OMe  Me   N                                      672                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     673                                                                               "  "          "         "  OMe  Me   CH                                     674                                                                               "  "          "         "  Cl   OMe  CH                                     675                                                                               "  "          "         "  OMe  Me   N                                      676                                                                               "  "          "         Me OMe  OMe  CH                                     677                                                                               "  "          "         "  "    Me   N                                      678                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     679                                                                               "  "          "         "  OMe  Me   N                                      680                                                                               "  "          "         "  OMe  Cl   CH                                     681                                                                               "  "          "         "  Me   Me   CH                                     682                                                                               "  "          "         Me OMe  OMe  CH                                     683                                                                               "  "          "         "  OMe  Me   N                                      684                                                                               "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     685                                                                               "  "          "         "  OMe  Me   N                                      686                                                                               "  "          "         "  Me   Me   CH                                     687                                                                               "  "          "         Me OMe  Me   N                                      688                                                                               n-Pr                                                                              COCHMeEt   CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     689                                                                               "  "          "         "  "    Cl   CH                                     690                                                                               "  "          "         "  Me   Me   CH                                     691                                                                               "  "          "         "  OMe  Me   N                                      692                                                                               "  "          "         Me OMe  OMe  CH                                     693                                                                               "  "          "         "  OMe  Me   N                                      694                                                                               n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      695                                                                               "  "          "         "  "    OMe  CH                                     696                                                                               "  "          "         "  Me   Me   CH                                     697                                                                               "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     698                                                                               i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     699                                                                               "  "          "         "  OMe  Me   N                                      700                                                                               "  "          "         "  Me   Me   CH                                     701                                                                               "  "          "         "  Cl   OMe  N                                      702                                                                               "  "          "         Me OMe  Me   N                                      703                                                                               "  "          "         "  "    OMe  CH                                     704                                                                               Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     705                                                                               "  "          "         "  "    Cl   CH                                     706                                                                               "  "          "         "  Me   Me   CH                                     707                                                                               "  "          "         "  OMe  Me   N                                      708                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     709                                                                               "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     710                                                                               "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     711                                                                               Me                                                                                 ##STR13## CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     712                                                                               "  "          "         "  OMe  OMe  N                                      713                                                                               "  "          "         "  "    Me   N                                      714                                                                               "  "          "         "  "    "    CH                                     715                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      716                                                                               "  "          "         "  Me   Me   CH                                     717                                                                               "  "          "         "  "    "    N                                      718                                                                               "  "          "         "  Cl   OMe  CH                                     719                                                                               "  "          "         Me OMe  OMe  CH                                     720                                                                               "  "          "         "  "    Me   N                                      721                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     722                                                                               "  "          "         "  "    Cl   CH                                     723                                                                               "  "          "         "  Me   Me   CH                                     724                                                                               "  "          "         "  OMe  Me   N                                      725                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      726                                                                               "  "          "         Me OMe  OMe  CH                                     727                                                                               "  "          "         "  OMe  Me   N                                      728                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     729                                                                               "  "          "         "  "    "    N                                      730                                                                               "  "          "         "  OMe  Me   N                                      731                                                                               "  "          "         "  Me   Me   CH                                     732                                                                               "  "          "         "  OMe  Cl   CH                                     733                                                                               "  "          "         Me Me   OMe  N                                      734                                                                               "  "          "         "  OMe  OMe  CH                                     735                                                                               Me                                                                                 ##STR14## CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     736                                                                               "  "          "         "  "    "    N                                      737                                                                               "  "          "         "  OMe  Me   N                                      738                                                                               "  "          "         "  OMe  Cl   CH                                     739                                                                               "  "          "         "  Me   Me   CH                                     740                                                                               "  "          "         "  SMe  NEt.sub.2                                                                           N                                      741                                                                               "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      742                                                                               "  "          "         "  OMe  OMe  CH                                     743                                                                               Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     744                                                                               Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     745                                                                               "  "          "         H  OMe  Me   N                                      746                                                                               "  "          "         "  Me   Me   CH                                     747                                                                               "  "          "         "  Cl   OMe  CH                                     748                                                                               "  "          "         Me OMe  OMe  CH                                     749                                                                               "  "          "         "  OMe  Me   N                                      750                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     751                                                                               "  "          "         "  OMe  Me   CH                                     752                                                                               "  "          "         "  Cl   OMe  CH                                     753                                                                               "  "          "         "  OMe  Me   N                                      754                                                                               "  "          "         Me OMe  OMe  CH                                     755                                                                               "  "          "         "  "    Me   N                                      756                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     757                                                                               "  "          "         "  OMe  Me   N                                      758                                                                               "  "          "         "  OMe  Cl   CH                                     759                                                                               "  "          "         "  Me   Me   CH                                     760                                                                               "  "          "         Me OMe  OMe  CH                                     761                                                                               "  "          "         "  OMe  Me   N                                      762                                                                               "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     763                                                                               "  "          "         "  OMe  Me   N                                      764                                                                               "  "          "         "  Me   Me   CH                                     765                                                                               "  "          "         Me OMe  Me   N                                      766                                                                               n-Pr                                                                               ##STR15## CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     767                                                                               "  "          "         "  "    Cl   CH                                     768                                                                               "  "          "         "  Me   Me   CH                                     769                                                                               "  "          "         "  OMe  Me   N                                      770                                                                               "  "          "         Me OMe  OMe  CH                                     771                                                                               "  "          "         "  OMe  Me   N                                      772                                                                               n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  OMe  OMe  N                                      773                                                                               "  "          "         "  "    OMe  CH                                     774                                                                               "  "          "         "  Me   Me   CH                                     775                                                                               "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     776                                                                               i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     777                                                                               "  "          "         "  OMe  Me   N                                      778                                                                               "  "          "         "  Me   Me   CH                                     779                                                                               "  "          "         "  Cl   OMe  N                                      780                                                                               "  "          "         Me OMe  Me   N                                      781                                                                               "  "          "         "  "    OMe  CH                                     782                                                                               Allyl                                                                             "          CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     783                                                                               "  "          "         "  "    Cl   CH                                     784                                                                               "  "          "         "  Me   Me   CH                                     785                                                                               "  "          "         "  OMe  Me   N                                      786                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     787                                                                               "  "          CO.sub.2 -n-Pr                                                                           "  "    "    "                                      788                                                                               "  "          CO.sub.2 -i-Pr                                                                           "  "    "    "                                      789                                                                               Me                                                                                 ##STR16## CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     790                                                                               "  "          "         "  "    OMe  N                                      791                                                                               "  "          "         "  "    Me   N                                      792                                                                               "  "          "         "  "    "    CH                                     793                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      794                                                                               "  "          "         "  Me   Me   CH                                     795                                                                               "  "          "         "  "    "    N                                      796                                                                               "  "          "         "  Cl   OMe  CH                                     797                                                                               "  "          "         Me OMe  OMe  CH                                     798                                                                               "  "          "         "  "    Me   N                                      799                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     800                                                                               "  "          "         "  "    Cl   CH                                     801                                                                               "  "          "         "  Me   Me   CH                                     802                                                                               "  "          "         "  OMe  Me   N                                      803                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      804                                                                               "  "          "         Me OMe  OMe  CH                                     805                                                                               "  "          "         "  OMe  Me   N                                      806                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     807                                                                               "  "          "         "  "    "    N                                      808                                                                               "  "          "         "  OMe  Me   N                                      809                                                                               "  "          "         "  Me   Me   CH                                     810                                                                               "  "          "         "  OMe  Cl   CH                                     811                                                                               "  "          "         Me Me   OMe  N                                      812                                                                               "  "          "         "  OMe  OMe  CH                                     813                                                                               Me "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     814                                                                               "  "          "         "  "    "    N                                      815                                                                               "  "          "         "  OMe  Me   N                                      816                                                                               "  "          "         "  OMe  Cl   CH                                     817                                                                               "  "          "         "  Me   Me   CH                                     818                                                                               "  "          "         "  SMe  NEt.sub.2                                                                           N                                      819                                                                               "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      820                                                                               "  "          "         "  OMe  OMe  CH                                     821                                                                               Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     822                                                                               Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     823                                                                               "  "          "         H  OMe  Me   N                                      824                                                                               "  "          "         "  Me   Me   CH                                     825                                                                               "  "          "         "  Cl   OMe  CH                                     826                                                                               "  "          "         Me OMe  OMe  CH                                     827                                                                               "  "          "         "  OMe  Me   N                                      828                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     829                                                                               "  "          "         "  OMe  Me   CH                                     830                                                                               "  "          "         "  Cl   OMe  CH                                     831                                                                               "  "          "         "  OMe  Me   N                                      832                                                                               "  "          "         Me OMe  OMe  CH                                     833                                                                               "  "          "         "  "    Me   N                                      834                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     835                                                                               "  "          "         "  OMe  Me   N                                      836                                                                               "  "          "         "  OMe  Cl   CH                                     837                                                                               "  "          "         "  Me   Me   CH                                     838                                                                               "  "          "         Me OMe  OMe  CH                                     839                                                                               "  "          "         "  OMe  Me   N                                      840                                                                               "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     841                                                                               "  "          "         "  OMe  Me   N                                      842                                                                               "  "          "         "  Me   Me   CH                                     843                                                                               "  "          "         Me OMe  Me   N                                      844                                                                               n-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     845                                                                               "  "          "         "  "    Cl   CH                                     846                                                                               "  "          "         "  Me   Me   CH                                     847                                                                               "  "          "         "  OMe  Me   N                                      848                                                                               "  "          "         Me OMe  OMe  CH                                     849                                                                               "  "          "         "  OMe  Me   N                                      850                                                                               n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      851                                                                               "  "          "         "  "    OMe  CH                                     852                                                                               "  "          "         "  Me   Me   CH                                     853                                                                               "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     854                                                                               i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     855                                                                               "  "          "         "  OMe  Me   N                                      856                                                                               "  "          "         "  Me   Me   CH                                     857                                                                               "  "          "         "  Cl   OMe  N                                      858                                                                               "  "          "         Me OMe  Me   N                                      859                                                                               "  "          "         "  "    OMe  CH                                     860                                                                               Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     861                                                                               "  "          "         "  "    Cl   CH                                     862                                                                               "  "          "         "  Me   Me   CH                                     863                                                                               "  "          "         "  OMe  Me   N                                      864                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     865                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     866                                                                               "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     867                                                                               Me                                                                                 ##STR17## CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     868                                                                               "  "          "         "  "    OMe  N                                      869                                                                               "  "          "         "  "    Me   N                                      870                                                                               "  "          "         "  "    "    CH                                     871                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      872                                                                               "  "          "         "  Me   Me   CH                                     873                                                                               "  "          "         "  "    Cl   N                                      874                                                                               "  "          "         "  Cl   OMe  CH                                     875                                                                               "  "          "         Me OMe  OMe  CH                                     876                                                                               "  "          "         "  "    Me   N                                      877                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     878                                                                               "  "          "         "  "    Cl   CH                                     879                                                                               "  "          "         "  Me   Me   CH                                     880                                                                               "  "          "         "  OMe  Me   N                                      881                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      882                                                                               "  "          "         Me OMe  OMe  CH                                     883                                                                               "  "          "         "  OMe  Me   N                                      884                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     885                                                                               "  "          "         "  "    "    N                                      886                                                                               "  "          "         "  OMe  Me   N                                      887                                                                               "  "          "         "  Me   Me   CH                                     888                                                                               "  "          "         "  OMe  Cl   CH                                     889                                                                               "  "          "         Me Me   OMe  N                                      890                                                                               "  "          "         "  OMe  OMe  CH                                     891                                                                               Me "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     892                                                                               "  "          "         "  "    "    N                                      893                                                                               "  "          "         "  H    Me   N                                      894                                                                               "  "          "         "  OMe  Cl   CH                                     895                                                                               "  "          "         "  Me   Me   CH                                     896                                                                               "  "          "         "  SMe  NEt.sub.2                                                                           N                                      897                                                                               "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      898                                                                               "  "          "         "  OMe  OMe  CH                                     899                                                                               Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     900                                                                               Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     901                                                                               "  "          "         H  OMe  Me   N                                      902                                                                               "  "          "         "  Me   Me   CH                                     903                                                                               "  "          "         "  Cl   OMe  CH                                     904                                                                               "  "          "         Me OMe  OMe  CH                                     905                                                                               "  "          "         "  OMe  Me   N                                      906                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     907                                                                               "  "          "         "  OMe  Me   CH                                     908                                                                               "  "          "         "  Cl   OMe  CH                                     909                                                                               "  "          "         "  OMe  Me   N                                      910                                                                               "  "          "         Me OMe  OMe  CH                                     911                                                                               "  "          "         "  "    Me   N                                      912                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     913                                                                               "  "          "         "  OMe  Me   N                                      914                                                                               "  "          "         "  OMe  Cl   CH                                     915                                                                               "  "          "         "  Me   Me   CH                                     916                                                                               "  "          "         Me OMe  OMe  CH                                     917                                                                               "  "          "         "  OMe  Me   N                                      918                                                                               "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     919                                                                               "  "          "         "  OMe  Me   N                                      920                                                                               "  "          "         "  Me   Me   CH                                     921                                                                               "  "          "         Me OMe  Me   N                                      922                                                                               n-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     923                                                                               "  "          "         "  "    Cl   CH                                     924                                                                               "  "          "         "  Me   Me   CH                                     925                                                                               "  "          "         "  OMe  Me   N                                      926                                                                               "  "          "         Me OMe  OMe  CH                                     927                                                                               "  "          "         "  OMe  Me   N                                      928                                                                               n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      929                                                                               "  "          "         "  "    OMe  CH                                     930                                                                               "  "          "         "  Me   Me   CH                                     931                                                                               "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     932                                                                               i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     933                                                                               "  "          "         "  OMe  Me   N                                      934                                                                               "  "          "         "  Me   Me   CH                                     935                                                                               "  "          "         "  Cl   OMe  N                                      936                                                                               "  "          "         Me OMe  Me   N                                      937                                                                               "  "          "         "  "    OMe  CH                                     938                                                                               Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     939                                                                               "  "          "         "  "    Cl   CH                                     940                                                                               "  "          "         "  Me   Me   CH                                     941                                                                               "  "          "         "  OMe  Me   N                                      942                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     943                                                                               "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     944                                                                               "  "          CO.sub.2 -i-Pr                                                                           "  "    "    "                                      945                                                                               Me                                                                                 ##STR18## CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                                                               164-167                              946                                                                               "  "          "         "  "    OMe  N                                      947                                                                               "  "          "         "  "    Me   N                                      948                                                                               "  "          "         "  "    "    CH                                     949                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      950                                                                               "  "          "         "  Me   Me   CH                                     951                                                                               "  "          "         "  "    "    N                                      952                                                                               "  "          "         "  Cl   OMe  CH                                     953                                                                               "  "          "         Me OMe  OMe  CH                                     954                                                                               "  "          "         "  "    Me   N                                      955                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     956                                                                               "  "          "         "  "    Cl   CH                                     957                                                                               "  "          "         "  Me   Me   CH                                     958                                                                               "  "          "         "  OMe  Me   N                                      959                                                                               "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      960                                                                               "  "          "         Me OMe  OMe  CH                                     961                                                                               "  "          "         "  OMe  Me   N                                      962                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     963                                                                               "  "          "         "  "    "    N                                      964                                                                               "  "          "         "  OMe  Me   N                                      965                                                                               "  "          "         "  Me   Me   CH                                     966                                                                               "  "          "         "  OMe  Cl   CH                                     967                                                                               "  "          "         Me Me   OMe  N                                      968                                                                               "  "          "         "  OMe  OMe  CH                                     969                                                                               Me                                                                                 ##STR19## CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     970                                                                               "  "          "         "  "    "    N                                      971                                                                               "  "          "         "  H    Me   N                                      972                                                                               "  "          "         "  OMe  Cl   CH                                     973                                                                               "  "          "         "  Me   Me   CH                                     974                                                                               "  "          "         "  SMe  NEt.sub.2                                                                           N                                      975                                                                               "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      976                                                                               "  "          "         "  OMe  OMe  CH                                     977                                                                               Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     978                                                                               Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     979                                                                               "  "          "         H  OMe  Me   N                                      980                                                                               "  "          "         "  Me   Me   CH                                     981                                                                               "  "          "         "  Cl   OMe  CH                                     982                                                                               "  "          "         Me OMe  OMe  CH                                     983                                                                               "  "          "         "  OMe  Me   N                                      984                                                                               "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     985                                                                               "  "          "         "  OMe  Me   CH                                     986                                                                               "  "          "         "  Cl   OMe  CH                                     987                                                                               "  "          "         "  OMe  Me   N                                      988                                                                               "  "          "         Me OMe  OMe  CH                                     989                                                                               "  "          "         "  "    Me   N                                      990                                                                               "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     991                                                                               "  "          "         "  OMe  Me   N                                      992                                                                               "  "          "         "  OMe  Cl   CH                                     993                                                                               "  "          "         "  Me   Me   CH                                     994                                                                               "  "          "         Me OMe  OMe  CH                                     995                                                                               "  "          "         "  OMe  Me   N                                      996                                                                               "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     997                                                                               "  "          "         "  OMe  Me   N                                      998                                                                               "  "          "         "  Me   Me   CH                                     999                                                                               "  "          "         Me OMe  Me   N                                      1.000                                                                             n-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.001                                                                             "  "          "         "  "    Cl   CH                                     1.002                                                                             "  "          "         "  Me   Me   CH                                     1.003                                                                             "  "          "         "  OMe  Me   N                                      1.004                                                                             "  "          "         Me OMe  OMe  CH                                     1.005                                                                             "  "          "         "  OMe  Me   N                                      1.006                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      1.007                                                                             "  "          "         "  Cl   OMe  CH                                     1.008                                                                             "  "          "         "  Me   Me   CH                                     1.009                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     1.010                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.011                                                                             "  "          "         "  OMe  Me   N                                      1.012                                                                             "  "          "         "  Me   Me   CH                                     1.013                                                                             "  "          "         "  Cl   OMe  N                                      1.014                                                                             "  "          "         Me OMe  Me   N                                      1.015                                                                             "  "          "         "  "    OMe  CH                                     1.016                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.017                                                                             "  "          "         "  "    Cl   CH                                     1.018                                                                             "  "          "         "  Me   Me   CH                                     1.019                                                                             "  "          "         "  OMe  Me   N                                      1.020                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.021                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     1.022                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     1.023                                                                             Me CO-Ph      CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                                                               177-183                              1.024                                                                             "  "          "         "  "    OMe  N                                      1.025                                                                             "  "          "         "  "    Me   N                                      1.026                                                                             "  "          "         "  OMe  "    CH                                     1.027                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.028                                                                             "  "          "         "  Me   Me   CH                                     1.029                                                                             "  "          "         "  "    "    N                                      1.030                                                                             "  "          "         "  Cl   OMe  CH                                     1.031                                                                             "  "          "         Me OMe  OMe  CH                                     1.032                                                                             "  "          "         "  "    Me   N                                      1.033                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.034                                                                             "  "          "         "  "    Cl   CH                                     1.035                                                                             "  "          "         "  Me   Me   CH                                     1.036                                                                             "  "          "         "  OMe  Me   N                                      1.037                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.038                                                                             "  "          "         Me OMe  OMe  CH                                     1.039                                                                             "  "          "         "  OMe  Me   N                                      1.040                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.041                                                                             "  "          "         "  "    "    N                                      1.042                                                                             "  "          "         "  OMe  Me   N                                      1.043                                                                             "  "          "         "  Me   Me   CH                                     1.044                                                                             "  "          "         "  OMe  Cl   CH                                     1.045                                                                             "  "          "         Me Me   OMe  N                                      1.046                                                                             "  "          "         "  OMe  OMe  CH                                     1.047                                                                             Me CO-Ph      CO.sub.2 -i-Pr                                                                           OMe                                                                               OMe  OMe  CH                                     1.048                                                                             "  "          "         "  "    "    N                                      1.049                                                                             "  "          "         "  OMe  Me   N                                      1.050                                                                             "  "          "         "  OMe  Cl   CH                                     1.051                                                                             "  "          "         "  Me   Me   CH                                     1.052                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      1.053                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      1.054                                                                             "  "          "         "  OMe  OMe  CH                                     1.055                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     1.056                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.057                                                                             "  "          "         H  OMe  Me   N                                      1.058                                                                             "  "          "         "  Me   Me   CH                                     1.059                                                                             "  "          "         "  Cl   OMe  CH                                     1.060                                                                             "  "          "         Me OMe  OMe  CH                                     1.061                                                                             "  "          "         "  OMe  Me   N                                      1.062                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.063                                                                             "  "          "         "  OMe  Me   CH                                     1.064                                                                             "  "          "         "  Cl   OMe  CH                                     1.065                                                                             "  "          "         "  OMe  Me   N                                      1.066                                                                             "  "          "         Me OMe  OMe  CH                                     1.067                                                                             "  "          "         "  "    Me   N                                      1.068                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.069                                                                             "  "          "         "  OMe  Me   N                                      1.070                                                                             "  "          "         "  OMe  Cl   CH                                     1.071                                                                             "  "          "         "  Me   Me   CH                                     1.072                                                                             "  "          "         Me OMe  OMe  CH                                     1.073                                                                             "  "          "         "  OMe  Me   N                                      1.074                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.075                                                                             "  "          "         "  OMe  Me   N                                      1.076                                                                             "  "          "         Me OMe  Me   N                                      1.077                                                                             n-Pr                                                                              CO-Ph      CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.078                                                                             "  "          "         "  "    Cl   CH                                     1.079                                                                             "  "          "         "  Me   Me   CH                                     1.080                                                                             "  "          "         "  OMe  Me   N                                      1.081                                                                             "  "          "         Me OMe  OMe  CH                                     1.082                                                                             "  "          "         "  OMe  Me   N                                      1.083                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      1.084                                                                             "  "          "         "  "    OMe  CH                                     1.085                                                                             "  "          "         "  Me   Me   CH                                     1.086                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     1.087                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.088                                                                             "  "          "         "  OMe  Me   N                                      1.089                                                                             "  "          "         "  Me   Me   CH                                     1.090                                                                             "  "          "         "  Cl   OMe  N                                      1.091                                                                             "  "          "         Me OMe  Me   N                                      1.092                                                                             "  "          "         "  "    OMe  CH                                     1.093                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.094                                                                             "  "          "         "  "    Cl   CH                                     1.095                                                                             "  "          "         "  Me   Me   CH                                     1.096                                                                             "  "          "         "  OMe  Me   N                                      1.097                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.098                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.099                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     1.100                                                                             Me                                                                                 ##STR20## CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.101                                                                             "  "          "         "  "    OMe  N                                      1.102                                                                             "  "          "         "  "    Me   N                                      1.103                                                                             "  "          "         "  "    "    CH                                     1.104                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.105                                                                             "  "          "         "  Me   Me   CH                                     1.106                                                                             "  "          "         "  "    "    N                                      1.107                                                                             "  "          "         "  Cl   OMe  CH                                     1.108                                                                             "  "          "         Me OMe  OMe  CH                                     1.109                                                                             "  "          "         "  "    Me   N                                      1.110                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.111                                                                             "  "          "         "  "    Cl   CH                                     1.112                                                                             "  "          "         "  Me   Me   CH                                     1.113                                                                             "  "          "         "  OMe  Me   N                                      1.114                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.115                                                                             "  "          "         Me OMe  OMe  CH                                     1.116                                                                             "  "          "         "  OMe  Me   N                                      1.117                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.118                                                                             "  "          "         "  "    "    N                                      1.119                                                                             "  "          "         "  OMe  Me   N                                      1.120                                                                             "  "          "         "  Me   Me   CH                                     1.121                                                                             "  "          "         "  OMe  Cl   CH                                     1.122                                                                             "  "          "         Me Me   OMe  N                                      1.123                                                                             "  "          "         "  OMe  OMe  CH                                     1.124                                                                             Me "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.125                                                                             "  "          "         "  "    "    N                                      1.126                                                                             "  "          "         "  H    Me   N                                      1.127                                                                             "  "          "         "  OMe  Cl   CH                                     1.128                                                                             "  "          "         "  Me   Me   CH                                     1.129                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      1.130                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      1.131                                                                             "  "          "         "  OMe  OMe  CH                                     1.132                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     1.133                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.134                                                                             "  "          "         H  OMe  Me   N                                      1.135                                                                             "  "          "         "  Me   Me   CH                                     1.136                                                                             "  "          "         "  Cl   OMe  CH                                     1.137                                                                             "  "          "         Me OMe  OMe  CH                                     1.138                                                                             "  "          "         "  OMe  Me   N                                      1.139                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.140                                                                             "  "          "         "  OMe  Me   CH                                     1.141                                                                             "  "          "         "  Cl   OMe  CH                                     1.142                                                                             "  "          "         "  OMe  Me   N                                      1.143                                                                             "  "          "         Me OMe  OMe  CH                                     1.144                                                                             "  "          "         "  "    Me   N                                      1.145                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.146                                                                             "  "          "         "  OMe  Me   N                                      1.147                                                                             "  "          "         "  OMe  Cl   CH                                     1.148                                                                             "  "          "         "  Me   Me   CH                                     1.149                                                                             "  "          "         Me OMe  OMe  CH                                     1.150                                                                             "  "          "         Me OMe  Me   N                                      1.151                                                                             "  "          CO.sub.2 i-Pr                                                                            H  OMe  OMe  CH                                     1.152                                                                             "  "          "         "  OMe  Me   N                                      1.153                                                                             "  "          "         "  Me   Me   CH                                     1.154                                                                             "  "          "         Me OMe  Me   N                                      1.155                                                                             n-Pr                                                                               ##STR21## CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.156                                                                             "  "          "         "  "    Cl   CH                                     1.157                                                                             "  "          "         "  Me   Me   CH                                     1.158                                                                             "  "          "         "  OMe  Me   N                                      1.159                                                                             "  "          "         Me OMe  OMe  CH                                     1.160                                                                             "  "          "         "  OMe  Me   N                                      1.161                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  OMe  Me   N                                      1.162                                                                             "  "          "         "  "    OMe  CH                                     1.163                                                                             "  "          "         "  Me   Me   CH                                     1.164                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     1.165                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.166                                                                             "  "          "         "  OMe  Me   N                                      1.167                                                                             "  "          "         "  Me   Me   CH                                     1.168                                                                             "  "          "         "  Cl   OMe  N                                      1.169                                                                             "  "          "         Me OMe  Me   N                                      1.170                                                                             "  "          "         "  "    OMe  CH                                     1.171                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.172                                                                             "  "          "         "  "    Cl   CH                                     1.173                                                                             "  "          "         "  Me   Me   CH                                     1.174                                                                             "  "          "         "  OMe  Me   N                                      1.175                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.176                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     1.177                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.178                                                                             Me COOMe      CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                                                               128° C.                       1.179                                                                             "  "          "         "  "    OMe  N                                      1.180                                                                             "  "          "         "  "    Me   N s. Bsp. o)                           1.181                                                                             "  "          "         "  "    "    CH                                                                                89-101                              1.182                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.183                                                                             "  "          "         "  Me   Me   CH                                                                               s. Bsp. m)                           1.184                                                                             "  "          "         "  "    "    N                                      1.185                                                                             "  "          "         "  Cl   OMe  CH                                                                               s. Bsp. n)                           1.186                                                                             "  "          "         Me OMe  OMe  CH                                                                               150-154                              1.187                                                                             "  "          "         "  "    Me   N                                      1.188                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.189                                                                             "  "          "         "  "    Cl   CH                                     1.190                                                                             "  "          "         "  Me   Me   CH                                     1.191                                                                             "  "          "         "  OMe  Me   N                                      1.192                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.193                                                                             "  "          "         Me OMe  OMe  CH                                     1.194                                                                             "  "          "         "  OMe  Me   N                                      1.195                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.196                                                                             "  "          "         "  "    "    N                                      1.197                                                                             "  "          "         "  OMe  Me   N                                      1.198                                                                             "  "          "         "  Me   Me   CH                                     1.199                                                                             "  "          "         "  OMe  Cl   CH                                     1.200                                                                             "  "          "         Me Me   OMe  N                                      1.201                                                                             "  "          "         "  OMe  OMe  CH                                     1.202                                                                             Me COOMe      CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.203                                                                             "  "          "         "  "    "    N                                      1.204                                                                             "  "          "         "  OMe  Me   N                                      1.205                                                                             "  "          "         "  OMe  Cl   CH                                     1.206                                                                             "  "          "         "  Me   Me   CH                                     1.207                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      1.208                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      1.209                                                                             "  "          "         "  OMe  OMe  CH                                     1.210                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     1.211                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.212                                                                             "  "          "         H  OMe  Me   N                                      1.213                                                                             "  "          "         "  Me   Me   CH                                     1.214                                                                             "  "          "         "  Cl   OMe  CH                                     1.215                                                                             "  "          "         Me OMe  OMe  CH                                     1.216                                                                             "  "          "         "  OMe  Me   N                                      1.217                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.218                                                                             "  "          "         "  OMe  Me   CH                                     1.219                                                                             "  "          "         "  Cl   OMe  CH                                     1.220                                                                             "  "          "         "  OMe  Me   N                                      1.221                                                                             "  "          "         Me OMe  OMe  CH                                     1.222                                                                             "  "          "         "  "    Me   N                                      1.223                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.224                                                                             "  "          "         "  OMe  Me   N                                      1.225                                                                             "  "          "         "  OMe  Cl   CH                                     1.226                                                                             "  "          "         "  Me   Me   CH                                     1.227                                                                             "  "          "         Me OMe  OMe  CH                                     1.228                                                                             "  "          "         "  OMe  Me   N                                      1.229                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.230                                                                             "  "          "         "  OMe  Me   N                                      1.231                                                                             "  "          "         "  Me   Me   CH                                     1.232                                                                             "  "          "         Me OMe  Me   N                                      1.233                                                                             n-Pr                                                                              COOMe      CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.234                                                                             "  "          "         "  "    Cl   CH                                     1.235                                                                             "  "          "         "  Me   Me   CH                                     1.236                                                                             "  "          "         "  OMe  Me   N                                      1.237                                                                             "  "          "         Me OMe  OMe  CH                                     1.238                                                                             "  "          "         "  OMe  Me   N                                      1.239                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  OMe  Me   N                                      1.240                                                                             "  "          "         "  "    OMe  CH                                     1.241                                                                             "  "          "         "  Me   Me   CH                                     1.242                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     1.243                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.244                                                                             "  "          "         "  OMe  Me   N                                      1.245                                                                             "  "          "         "  Me   Me   CH                                     1.246                                                                             "  "          "         "  Cl   OMe  N                                      1.247                                                                             "  "          "         Me OMe  Me   N                                      1.248                                                                             "  "          "         "  "    OMe  CH                                     1.249                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.250                                                                             "  "          "         "  "    Cl   CH                                     1.251                                                                             "  "          "         "  Me   Me   CH                                     1.252                                                                             "  "          "         "  OMe  Me   N                                      1.253                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.254                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    "                                      1.255                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     1.256                                                                             Me COOEt      CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                                                                90-94                               1.257                                                                             "  "          "         "  "    OMe  N                                      1.258                                                                             "  "          "         "  "    Me   N                                      1.259                                                                             "  "          "         "  "    "    CH                                     1.260                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.261                                                                             "  "          "         "  Me   Me   CH                                     1.262                                                                             "  "          "         "  "    "    N                                      1.263                                                                             "  "          "         "  Cl   OMe  CH                                     1.264                                                                             "  "          "         Me OMe  OMe  CH                                     1.265                                                                             "  "          "         "  "    Me   N                                      1.266                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.267                                                                             "  "          "         "  "    Cl   CH                                     1.268                                                                             "  "          "         "  Me   Me   CH                                     1.269                                                                             "  "          "         "  OMe  Me   N                                      1.270                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.271                                                                             "  "          "         Me OMe  OMe  CH                                     1.272                                                                             "  "          "         "  OMe  Me   N                                      1.273                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.274                                                                             "  "          "         "  "    "    N                                      1.275                                                                             "  "          "         "  OMe  Me   N                                      1.276                                                                             "  "          "         "  Me   Me   CH                                     1.277                                                                             "  "          "         "  OMe  Cl   CH                                     1.278                                                                             "  "          "         Me Me   OMe  N                                      1.279                                                                             "  "          "         "  OMe  OMe  CH                                     1.280                                                                             Me COOEt      CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.281                                                                             "  "          "         "  "    "    N                                      1.282                                                                             "  "          "         "  OMe  Me   N                                      1.283                                                                             "  "          "         "  OMe  Cl   CH                                     1.284                                                                             "  "          "         "  Me   Me   CH                                     1.285                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      1.286                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      1.287                                                                             "  "          "         "  OMe  OMe  CH                                     1.288                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     1.289                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.290                                                                             "  "          "         H  OMe  Me   N                                      1.291                                                                             "  "          "         "  Me   Me   CH                                     1.292                                                                             "  "          "         "  Cl   OMe  CH                                     1.293                                                                             "  "          "         Me OMe  OMe  CH                                     1.294                                                                             "  "          "         "  OMe  Me   N                                      1.295                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.296                                                                             "  "          "         "  OMe  Me   CH                                     1.297                                                                             "  "          "         "  Cl   OMe  CH                                     1.298                                                                             "  "          "         "  OMe  Me   N                                      1.299                                                                             "  "          "         Me OMe  OMe  CH                                     1.300                                                                             "  "          "         "  "    Me   N                                      1.301                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.302                                                                             "  "          "         "  OMe  Me   N                                      1.303                                                                             "  "          "         "  OMe  Cl   CH                                     1.304                                                                             "  "          "         "  Me   Me   CH                                     1.305                                                                             "  "          "         Me OMe  OMe  CH                                     1.306                                                                             "  "          "         "  OMe  Me   N                                      1.307                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.308                                                                             "  "          "         "  OMe  Me   N                                      1.309                                                                             "  "          "         "  Me   Me   CH                                     1.310                                                                             "  "          "         Me OMe  Me   N                                      1.311                                                                             n-Pr                                                                              COOEt      CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.312                                                                             "  "          "         "  "    Cl   CH                                     1.313                                                                             "  "          "         "  Me   Me   CH                                     1.314                                                                             "  "          "         "  OMe  Me   N                                      1.315                                                                             "  "          "         Me OMe  OMe  CH                                     1.316                                                                             "  "          "         "  OMe  Me   N                                      1.317                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      1.318                                                                             "  "          "         "  "    OMe  CH                                     1.319                                                                             "  "          "         "  Me   Me   CH                                     1.320                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     1.321                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.322                                                                             "  "          "         "  OMe  Me   N                                      1.323                                                                             "  "          "         "  Me   Me   CH                                     1.324                                                                             "  "          "         "  Cl   OMe  N                                      1.325                                                                             "  "          "         Me OMe  Me   N                                      1.326                                                                             "  "          "         "  "    OMe  CH                                     1.327                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.328                                                                             "  "          "         "  "    Cl   CH                                     1.329                                                                             "  "          "         "  Me   Me   CH                                     1.330                                                                             "  "          "         "  OMe  Me   N                                      1.331                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.332                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.333                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    "                                      1.334                                                                             Me COO-i-Pr   CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                                                               159-162                              1.335                                                                             "  "          "         "  "    OMe  N                                      1.336                                                                             "  "          "         "  "    Me   N                                      1.337                                                                             "  "          "         "  "    "    CH                                     1.338                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.339                                                                             "  "          "         "  Me   Me   CH                                     1.340                                                                             "  "          "         "  "    "    N                                      1.341                                                                             "  "          "         "  Cl   OMe  CH                                     1.342                                                                             "  "          "         Me OMe  OMe  CH                                     1.343                                                                             "  "          "         "  "    Me   N                                      1.344                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.345                                                                             "  "          "         "  "    Cl   CH                                     1.346                                                                             "  "          "         "  Me   Me   CH                                     1.347                                                                             "  "          "         "  OMe  Me   N                                      1.348                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.349                                                                             "  "          "         Me OMe  OMe  CH                                     1.350                                                                             "  "          "         "  OMe  Me   N                                      1.351                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.352                                                                             "  "          "         "  "    "    N                                      1.353                                                                             "  "          "         "  OMe  Me   N                                      1.354                                                                             "  "          "         "  Me   Me   CH                                     1.355                                                                             "  "          "         "  OMe  Cl   CH                                     1.356                                                                             "  "          "         Me Me   OMe  N                                      1.357                                                                             "  "          "         "  OMe  OMe  CH                                     1.358                                                                             Me COO-i-Pr   CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.359                                                                             "  "          "         "  "    "    N                                      1.360                                                                             "  "          "         "  H    Me   N                                      1.361                                                                             "  "          "         "  OMe  Cl   CH                                     1.362                                                                             "  "          "         "  Me   Me   CH                                     1.363                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      1.364                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  N                                           1.365                                                                             "  "          "         "  OMe  OMe  CH                                     1.366                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     1.367                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.368                                                                             "  "          "         H  OMe  Me   N                                      1.369                                                                             "  "          "         "  Me   Me   CH                                     1.370                                                                             "  "          "         "  Cl   OMe  CH                                     1.371                                                                             "  "          "         Me OMe  OMe  CH                                     1.372                                                                             "  "          "         "  OMe  Me   N                                      1.373                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.374                                                                             "  "          "         "  OMe  Me   CH                                     1.375                                                                             "  "          "         "  Cl   OMe  CH                                     1.376                                                                             "  "          "         "  OMe  Me   N                                      1.377                                                                             "  "          "         Me OMe  OMe  CH                                     1.378                                                                             "  "          "         "  "    Me   N                                      1.379                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.380                                                                             "  "          "         "  OMe  Me   N                                      1.381                                                                             "  "          "         "  OMe  Cl   CH                                     1.382                                                                             "  "          "         "  Me   Me   CH                                     1.383                                                                             "  "          "         Me OMe  OMe  CH                                     1.384                                                                             "  "          "         "  OMe  Me   N                                      1.385                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.386                                                                             "  "          "         "  OMe  Me   N                                      1.387                                                                             "  "          "         "  Me   Me   CH                                     1.388                                                                             "  "          "         Me OMe  Me   N                                      1.389                                                                             n-Pr                                                                              COO-i-Pr   CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.390                                                                             "  "          "         "  "    Cl   CH                                     1.391                                                                             "  "          "         "  Me   Me   CH                                     1.392                                                                             "  "          "         "  OMe  Me   N                                      1.393                                                                             "  "          "         Me OMe  OMe  CH                                     1.394                                                                             "  "          "         "  OMe  Me   N                                      1.395                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      1.396                                                                             "  "          "         "  "    OMe  CH                                     1.397                                                                             "  "          "         "  Me   Me   CH                                     1.398                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     1.399                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.400                                                                             "  "          "         "  OMe  Me   N                                      1.401                                                                             "  "          "         "  Me   Me   CH                                     1.402                                                                             "  "          "         "  Cl   OMe  N                                      1.403                                                                             "  "          "         Me OMe  Me   N                                      1.404                                                                             "  "          "         "  "    OMe  CH                                     1.405                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.406                                                                             "  "          "         "  "    Cl   CH                                     1.407                                                                             "  "          "         "  Me   Me   CH                                     1.408                                                                             "  "          "         "  OMe  Me   N                                      1.409                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.410                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     1.411                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     1.412                                                                             Me COO-n-Pr   CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.413                                                                             "  "          "         "  "    OMe  N                                      1.414                                                                             "  "          "         "  "    Me   N                                      1.415                                                                             "  "          "         "  "    "    CH                                     1.416                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.417                                                                             "  "          "         "  Me   Me   CH                                     1.418                                                                             "  "          "         "  "    "    N                                      1.419                                                                             "  "          "         "  Cl   OMe  CH                                     1.420                                                                             "  "          "         Me OMe  OMe  CH                                     1.421                                                                             "  "          "         "  "    Me   N                                      1.422                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.423                                                                             "  "          "         "  "    Cl   CH                                     1.424                                                                             "  "          "         "  Me   Me   CH                                     1.425                                                                             "  "          "         "  OMe  Me   N                                      1.426                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.427                                                                             "  "          "         Me OMe  OMe  CH                                     1.428                                                                             "  "          "         "  OMe  Me   N                                      1.429                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.430                                                                             "  "          "         "  "    "    N                                      1.431                                                                             "  "          "         "  OMe  Me   N                                      1.432                                                                             "  "          "         "  Me   Me   CH                                     1.433                                                                             "  "          "         "  OMe  Cl   CH                                     1.434                                                                             "  "          "         Me Me   OMe  N                                      1.435                                                                             "  "          "         "  OMe  OMe  CH                                     1.436                                                                             Me COO-n-Pr   CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.437                                                                             "  "          "         "  "    "    N                                      1.438                                                                             "  "          "         "  OMe  Me   N                                      1.439                                                                             "  "          "         "  OMe  Cl   CH                                     1.440                                                                             "  "          "         "  Me   Me   CH                                     1.441                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      1.442                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      1.443                                                                             "  "          "         "  OMe  OMe  CH                                     1.444                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     1.445                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.446                                                                             "  "          "         H  OMe  Me   N                                      1.447                                                                             "  "          "         "  Me   Me   CH                                     1.448                                                                             "  "          "         "  Cl   OMe  CH                                     1.449                                                                             "  "          "         Me OMe  OMe  CH                                     1.450                                                                             "  "          "         "  OMe  Me   N                                      1.451                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.452                                                                             "  "          "         "  OMe  Me   CH                                     1.453                                                                             "  "          "         "  Cl   OMe  CH                                     1.454                                                                             "  "          "         "  OMe  Me   N                                      1.455                                                                             "  "          "         Me OMe  OMe  CH                                     1.456                                                                             "  "          "         "  "    Me   N                                      1.457                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.458                                                                             "  "          "         "  OMe  Me   N                                      1.459                                                                             "  "          "         "  OMe  Cl   CH                                     1.460                                                                             "  "          "         "  Me   Me   CH                                     1.461                                                                             "  "          "         Me OMe  OMe  CH                                     1.462                                                                             "  "          "         "  OMe  Me   N                                      1.463                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.464                                                                             "  "          "         "  OMe  Me   N                                      1.465                                                                             "  "          "         "  Me   Me   CH                                     1.466                                                                             "  "          "         Me OMe  Me   N                                      1.467                                                                             n-Pr                                                                              COO-n-Pr   CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.468                                                                             "  "          "         "  "    Cl   CH                                     1.469                                                                             "  "          "         "  Me   Me   CH                                     1.470                                                                             "  "          "         "  OMe  Me   N                                      1.471                                                                             "  "          "         Me OMe  OMe  CH                                     1.472                                                                             "  "          "         "  OMe  Me   N                                      1.473                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      1.474                                                                             "  "          "         "  "    OMe  CH                                     1.475                                                                             "  "          "         "  Me   Me   CH                                     1.476                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     1.477                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.478                                                                             "  "          "         "  OMe  Me   N                                      1.479                                                                             "  "          "         "  Me   Me   CH                                     1.480                                                                             "  "          "         "  Cl   OMe  N                                      1.481                                                                             "  "          "         Me OMe  Me   N                                      1.482                                                                             "  "          "         "  "    OMe  CH                                     1.483                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.484                                                                             "  "          "         "  "    Cl   CH                                     1.485                                                                             "  "          "         "  Me   Me   CH                                     1.486                                                                             "  "          "         "  OMe  Me   N                                      1.487                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.488                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     1.489                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     1.490                                                                             Me COO-allyl  CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.491                                                                             "  "          "         "  "    OMe  N                                      1.492                                                                             "  "          "         "  "    Me   N                                      1.493                                                                             "  "          "         "  "    "    CH                                     1.494                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.495                                                                             "  "          "         "  Me   Me   CH                                     1.496                                                                             "  "          "         "  "    "    N                                      1.497                                                                             "  "          "         "  Cl   OMe  CH                                     1.498                                                                             "  "          "         Me OMe  OMe  CH                                     1.499                                                                             "  "          "         "  "    Me   N                                      1.500                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.501                                                                             "  "          "         "  "    Cl   CH                                     1.502                                                                             "  "          "         "  Me   Me   CH                                     1.503                                                                             "  "          "         "  OMe  Me   N                                      1.504                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.505                                                                             "  "          "         Me OMe  OMe  CH                                     1.506                                                                             "  "          "         "  OMe  Me   N                                      1.507                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.508                                                                             "  "          "         "  "    "    N                                      1.509                                                                             "  "          "         "  OMe  Me   N                                      1.510                                                                             "  "          "         "  Me   Me   CH                                     1.511                                                                             "  "          "         "  OMe  Cl   CH                                     1.512                                                                             "  "          "         Me Me   OMe  N                                      1.513                                                                             "  "          "         "  OMe  OMe  CH                                     1.514                                                                             Me COO-allyl  CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.515                                                                             "  "          "         "  "    "    N                                      1.516                                                                             "  "          "         "  H    Me   N                                      1.517                                                                             "  "          "         "  OMe  Cl   CH                                     1.518                                                                             "  "          "         "  Me   Me   CH                                     1.519                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      1.520                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      1.521                                                                             "  "          "         "  OMe  OMe  CH                                     1.522                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     1.523                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.524                                                                             "  "          "         H  OMe  Me   N                                      1.525                                                                             "  "          "         "  Me   Me   CH                                     1.526                                                                             "  "          "         "  Cl   OMe  CH                                     1.527                                                                             "  "          "         Me OMe  OMe  CH                                     1.528                                                                             "  "          "         "  OMe  Me   N                                      1.529                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.530                                                                             "  "          "         "  OMe  Me   CH                                     1.531                                                                             "  "          "         "  Cl   OMe  CH                                     1.532                                                                             "  "          "         "  OMe  Me   N                                      1.533                                                                             "  "          "         Me OMe  OMe  CH                                     1.534                                                                             "  "          "         "  "    Me   N                                      1.535                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.536                                                                             "  "          "         "  OMe  Me   N                                      1.537                                                                             "  "          "         "  OMe  Cl   CH                                     1.538                                                                             "  "          "         "  Me   Me   CH                                     1.539                                                                             "  "          "         Me OMe  OMe  CH                                     1.540                                                                             "  "          "         "  OMe  Me   N                                      1.541                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.542                                                                             "  "          "         "  OMe  Me   N                                      1.543                                                                             "  "          "         "  Me   Me   CH                                     1.544                                                                             "  "          "         Me OMe  Me   N                                      1.545                                                                             n-Pr                                                                              COO-allyl  CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.546                                                                             "  "          "         "  "    Cl   CH                                     1.547                                                                             "  "          "         "  Me   Me   CH                                     1.548                                                                             "  "          "         "  OMe  Me   N                                      1.549                                                                             "  "          "         Me OMe  OMe  CH                                     1.550                                                                             "  "          "         "  OMe  Me   N                                      1.551                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      1.552                                                                             "  "          "         "  "    OMe  CH                                     1.553                                                                             "  "          "         "  Me   Me   CH                                     1.554                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     1.555                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.556                                                                             "  "          "         "  OMe  Me   N                                      1.557                                                                             "  "          "         "  Me   Me   CH                                     1.558                                                                             "  "          "         "  Cl   OMe  N                                      1.559                                                                             "  "          "         Me OMe  Me   N                                      1.560                                                                             "  "          "         "  "    OMe  CH                                     1.561                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.562                                                                             "  "          "         "  "    Cl   CH                                     1.563                                                                             "  "          "         "  Me   Me   CH                                     1.564                                                                             "  "          "         "  OMe  Me   N                                      1.565                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.566                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     1.567                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     1.568                                                                             Me CONHEt     CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.569                                                                             "  "          "         "  "    OMe  N                                      1.570                                                                             "  "          "         "  "    Me   N                                      1.571                                                                             "  "          "         "  "    "    CH                                     1.572                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.573                                                                             "  "          "         "  Me   Me   CH                                     1.574                                                                             "  "          "         "  "    "    N                                      1.575                                                                             "  "          "         "  Cl   OMe  CH                                     1.576                                                                             "  "          "         Me OMe  OMe  CH                                     1.577                                                                             "  "          "         "  "    Me   N                                      1.578                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.579                                                                             "  "          "         "  "    Cl   CH                                     1.580                                                                             "  "          "         "  Me   Me   CH                                     1.581                                                                             "  "          "         "  OMe  Me   N                                      1.582                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.583                                                                             "  "          "         Me OMe  OMe  CH                                     1.584                                                                             "  "          "         "  OMe  Me   N                                      1.585                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.586                                                                             "  "          "         "  "    "    N                                      1.587                                                                             "  "          "         "  OMe  Me   N                                      1.588                                                                             "  "          "         "  Me   Me   CH                                     1.589                                                                             "  "          "         "  OMe  Cl   CH                                     1.590                                                                             "  "          "         Me Me   OMe  N                                      1.591                                                                             "  "          "         "  OMe  OMe  CH                                     1.592                                                                             Me CONHEt     CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.593                                                                             "  "          "         "  "    "    N                                      1.594                                                                             "  "          "         "  OMe  Me   N                                      1.595                                                                             "  "          "         "  OMe  Cl   CH                                     1.596                                                                             "  "          "         "  Me   Me   CH                                     1.597                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      1.598                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      1.599                                                                             "  "          "         "  OMe  OMe  CH                                     1.600                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     1.601                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.602                                                                             "  "          "         H  OMe  Me   N                                      1.603                                                                             "  "          "         "  Me   Me   CH                                     1.604                                                                             "  "          "         "  Cl   OMe  CH                                     1.605                                                                             "  "          "         Me OMe  OMe  CH                                     1.606                                                                             "  "          "         "  OMe  Me   N                                      1.607                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.608                                                                             "  "          "         "  OMe  Me   CH                                     1.609                                                                             "  "          "         "  Cl   OMe  CH                                     1.610                                                                             "  "          "         "  OMe  Me   N                                      1.611                                                                             "  "          "         Me OMe  OMe  CH                                     1.612                                                                             "  "          "         "  "    Me   N                                      1.613                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.614                                                                             "  "          "         "  OMe  Me   N                                      1.615                                                                             "  "          "         "  OMe  Cl   CH                                     1.616                                                                             "  "          "         "  Me   Me   CH                                     1.617                                                                             "  "          "         Me OMe  OMe  CH                                     1.618                                                                             "  "          "         "  OMe  Me   N                                      1.619                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.620                                                                             "  "          "         "  OMe  Me   N                                      1.621                                                                             "  "          "         "  Me   Me   CH                                     1.622                                                                             "  "          "         Me OMe  Me   N                                      1.623                                                                             n-Pr                                                                              CONHEt     CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.624                                                                             "  "          "         "  "    Cl   CH                                     1.625                                                                             "  "          "         "  Me   Me   CH                                     1.626                                                                             "  "          "         "  OMe  Me   N                                      1.627                                                                             "  "          "         Me OMe  OMe  CH                                     1.628                                                                             "  "          "         "  OMe  Me   N                                      1.629                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      1.630                                                                             "  "          "         "  "    OMe  CH                                     1.631                                                                             "  "          "         "  Me   Me   CH                                     1.632                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     1.633                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.634                                                                             "  "          "         "  OMe  Me   N                                      1.635                                                                             "  "          "         "  Me   Me   CH                                     1.636                                                                             "  "          "         "  Cl   OMe  N                                      1.637                                                                             "  "          "         Me OMe  Me   N                                      1.638                                                                             "  "          "         "  "    OMe  CH                                     1.639                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.640                                                                             "  "          "         "  "    Cl   CH                                     1.641                                                                             "  "          "         "  Me   Me   CH                                     1.642                                                                             "  "          "         "  OMe  Me   N                                      1.643                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.644                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     1.645                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     1.646                                                                             Me CONHPr     CO.sub.2 -Me                                                                             H  "    "    CH                                     1.647                                                                             "  "          "         "  "    OMe  N                                      1.648                                                                             "  "          "         "  "    Me   N                                      1.649                                                                             "  "          "         "  "    "    CH                                     1.650                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.651                                                                             "  "          "         "  Me   Me   CH                                     1.652                                                                             "  "          "         "  "    "    N                                      1.653                                                                             "  "          "         "  Cl   OMe  CH                                     1.654                                                                             "  "          "         Me OMe  OMe  CH                                     1.655                                                                             "  "          "         "  "    Me   N                                      1.656                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.657                                                                             "  "          "         "  "    Cl   CH                                     1.658                                                                             "  "          "         "  Me   Me   CH                                     1.659                                                                             "  "          "         "  OMe  Me   N                                      1.660                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.661                                                                             "  "          "         Me OMe  OMe  CH                                     1.662                                                                             "  "          "         "  OMe  Me   N                                      1.663                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.664                                                                             "  "          "         "  "    "    N                                      1.665                                                                             "  "          "         "  OMe  Me   N                                      1.666                                                                             "  "          "         "  Me   Me   CH                                     1.667                                                                             "  "          "         "  OMe  Cl   CH                                     1.668                                                                             "  "          "         Me Me   OMe  N                                      1.669                                                                             "  "          "         "  OMe  OMe  CH                                     1.670                                                                             Me CONHPr     CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.671                                                                             "  "          "         "  "    "    N                                      1.672                                                                             "  "          "         "  OMe  Me   N                                      1.673                                                                             "  "          "         "  OMe  Cl   CH                                     1.674                                                                             "  "          "         "  Me   Me   CH                                     1.675                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      1.676                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      1.677                                                                             "  "          "         "  OMe  OMe  CH                                     1.678                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     1.679                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.680                                                                             "  "          "         H  OMe  Me   N                                      1.681                                                                             "  "          "         "  Me   Me   CH                                     1.682                                                                             "  "          "         "  Cl   OMe  CH                                     1.683                                                                             "  "          "         Me OMe  OMe  CH                                     1.684                                                                             "  "          "         "  OMe  Me   N                                      1.685                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.686                                                                             "  "          "         "  OMe  Me   CH                                     1.687                                                                             "  "          "         "  Cl   OMe  CH                                     1.688                                                                             "  "          "         "  OMe  Me   N                                      1.689                                                                             "  "          "         Me OMe  OMe  CH                                     1.690                                                                             "  "          "         "  "    Me   N                                      1.691                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.692                                                                             "  "          "         "  OMe  Me   N                                      1.693                                                                             "  "          "         "  OMe  Cl   CH                                     1.694                                                                             "  "          "         "  Me   Me   CH                                     1.695                                                                             "  "          "         Me OMe  OMe  CH                                     1.696                                                                             "  "          "         "  OMe  Me   N                                      1.697                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.698                                                                             "  "          "         "  OMe  Me   N                                      1.699                                                                             "  "          "         "  Me   Me   CH                                     1.700                                                                             "  "          "         Me OMe  Me   N                                      1.701                                                                             n-Pr                                                                              "          CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     1.702                                                                             "  "          "         "  "    Cl   CH                                     1.703                                                                             "  "          "         "  Me   Me   CH                                     1.704                                                                             "  "          "         "  OMe  Me   N                                      1.705                                                                             "  "          "         Me OMe  OMe  CH                                     1.706                                                                             "  "          "         "  OMe  Me   N                                      1.707                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      1.708                                                                             "  "          "         "  "    OMe  CH                                     1.709                                                                             "  "          "         "  Me   Me   CH                                     1.710                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     1.711                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.712                                                                             "  "          "         "  OMe  Me   N                                      1.713                                                                             "  "          "         "  Me   Me   CH                                     1.714                                                                             "  "          "         "  Cl   OMe  N                                      1.715                                                                             "  "          "         Me OMe  Me   N                                      1.716                                                                             "  "          "         "  "    OMe  CH                                     1.717                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.718                                                                             "  "          "         "  "    Cl   CH                                     1.719                                                                             "  "          "         "  Me   Me   CH                                     1.720                                                                             "  "          "         "  OMe  Me   N                                      1.721                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.722                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     1.723                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     1.724                                                                             Me CONH-allyl CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.725                                                                             "  "          "         "  "    OMe  N                                      1.726                                                                             "  "          "         "  "    Me   N                                      1.727                                                                             "  "          "         "  "    "    CH                                     1.728                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.729                                                                             "  "          "         "  Me   Me   CH                                     1.730                                                                             "  "          "         "  "    "    N                                      1.731                                                                             "  "          "         "  Cl   OMe  CH                                     1.732                                                                             "  "          "         Me OMe  OMe  CH                                     1.733                                                                             "  "          "         "  "    Me   N                                      1.734                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.735                                                                             "  "          "         "  "    Cl   CH                                     1.736                                                                             "  "          "         "  Me   Me   CH                                     1.737                                                                             "  "          "         "  OMe  Me   N                                      1.738                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.739                                                                             "  "          "         Me OMe  OMe  CH                                     1.740                                                                             "  "          "         "  OMe  Me   N                                      1.741                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.742                                                                             "  "          "         "  "    "    N                                      1.743                                                                             "  "          "         "  OMe  Me   N                                      1.744                                                                             "  "          "         "  Me   Me   CH                                     1.745                                                                             "  "          "         "  OMe  Cl   CH                                     1.746                                                                             "  "          "         Me Me   OMe  N                                      1.747                                                                             "  "          "         "  OMe  OMe  CH                                     1.748                                                                             Me CONH-allyl CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.749                                                                             "  "          "         "  "    "    N                                      1.750                                                                             "  "          "         "  OMe  Me   N                                      1.751                                                                             "  "          "         "  OMe  Cl   CH                                     1.752                                                                             "  "          "         "  Me   Me   CH                                     1.753                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      1.754                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      1.755                                                                             "  "          "         "  OMe  OMe  CH                                     1.756                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     1.757                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.758                                                                             "  "          "         H  OMe  Me   N                                      1.759                                                                             "  "          "         "  Me   Me   CH                                     1.760                                                                             "  "          "         "  Cl   OMe  CH                                     1.761                                                                             "  "          "         Me OMe  OMe  CH                                     1.762                                                                             "  "          "         "  OMe  Me   N                                      1.763                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.764                                                                             "  "          "         "  OMe  Me   CH                                     1.765                                                                             "  "          "         "  Cl   OMe  CH                                     1.766                                                                             "  "          "         "  OMe  Me   N                                      1.767                                                                             "  "          "         Me OMe  OMe  CH                                     1.768                                                                             "  "          "         "  "    Me   N                                      1.769                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.770                                                                             "  "          "         "  OMe  Me   N                                      1.771                                                                             "  "          "         "  OMe  Cl   CH                                     1.772                                                                             "  "          "         "  Me   Me   CH                                     1.773                                                                             "  "          "         Me OMe  OMe  CH                                     1.774                                                                             "  "          "         "  OMe  Me   N                                      1.775                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.776                                                                             "  "          "         "  OMe  Me   N                                      1.777                                                                             "  "          "         "  Me   Me   CH                                     1.778                                                                             "  "          "         Me OMe  Me   N                                      1.779                                                                             n-Pr                                                                              CONH-allyl CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.780                                                                             "  "          "         "  "    Cl   CH                                     1.781                                                                             "  "          "         "  Me   Me   CH                                     1.782                                                                             "  "          "         "  OMe  Me   N                                      1.783                                                                             "  "          "         Me OMe  OMe  CH                                     1.784                                                                             "  "          "         "  OMe  Me   N                                      1.785                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  OMe  Me   N                                      1.786                                                                             "  "          "         "  "    OMe  CH                                     1.787                                                                             "  "          "         "  Me   Me   CH                                     1.788                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     1.789                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.790                                                                             "  "          "         "  OMe  Me   N                                      1.791                                                                             "  "          "         "  Me   Me   CH                                     1.792                                                                             "  "          "         "  Cl   OMe  N                                      1.793                                                                             "  "          "         Me OMe  Me   N                                      1.794                                                                             "  "          "         "  "    OMe  CH                                     1.795                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.796                                                                             "  "          "         "  "    Cl   CH                                     1.797                                                                             "  "          "         "  Me   Me   CH                                     1.798                                                                             "  "          "         "  OMe  Me   N                                      1.799                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.800                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    "                                      1.801                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    "                                      1.802                                                                             Me CSNHMe     CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                                                               190-193                              1.803                                                                             "  "          "         "  "    OMe  N                                      1.804                                                                             "  "          "         "  "    Me   N                                      1.805                                                                             "  "          "         "  "    "    CH                                     1.806                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.807                                                                             "  "          "         "  Me   Me   CH                                     1.808                                                                             "  "          "         "  "    "    N                                      1.809                                                                             "  "          "         "  Cl   OMe  CH                                     1.810                                                                             "  "          "         Me OMe  OMe  CH                                     1.811                                                                             "  "          "         "  "    Me   N                                      1.812                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.813                                                                             "  "          "         "  "    Cl   CH                                     1.814                                                                             "  "          "         "  Me   Me   CH                                     1.815                                                                             "  "          "         "  OMe  Me   N                                      1.816                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.817                                                                             "  "          "         Me OMe  OMe  CH                                     1.818                                                                             "  "          "         "  OMe  Me   N                                      1.819                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.820                                                                             "  "          "         "  "    "    N                                      1.821                                                                             "  "          "         "  OMe  Me   N                                      1.822                                                                             "  "          "         "  Me   Me   CH                                     1.823                                                                             "  "          "         "  OMe  Cl   CH                                     1.824                                                                             "  "          "         Me Me   OMe  N                                      1.825                                                                             "  "          "         "  OMe  OMe  CH                                     1.826                                                                             Me CSNHMe     CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.827                                                                             "  "          "         "  "    "    N                                      1.828                                                                             "  "          "         "  OMe  Me   N                                      1.829                                                                             "  "          "         "  OMe  Cl   CH                                     1.830                                                                             "  "          "         "  Me   Me   CH                                     1.831                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      1.832                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      1.833                                                                             "  "          "         "  OMe  OMe  CH                                     1.834                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     1.835                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.836                                                                             "  "          "         H  OMe  Me   N                                      1.837                                                                             "  "          "         "  Me   Me   CH                                     1.838                                                                             "  "          "         "  Cl   OMe  CH                                     1.839                                                                             "  "          "         Me OMe  OMe  CH                                     1.840                                                                             "  "          "         "  OMe  Me   N                                      1.841                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.842                                                                             "  "          "         "  OMe  Me   CH                                     1.843                                                                             "  "          "         "  Cl   OMe  CH                                     1.844                                                                             "  "          "         "  OMe  Me   N                                      1.845                                                                             "  "          "         Me OMe  OMe  CH                                     1.846                                                                             "  "          "         "  "    Me   N                                      1.847                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.848                                                                             "  "          "         "  OMe  Me   N                                      1.849                                                                             "  "          "         "  OMe  Cl   CH                                     1.850                                                                             "  "          "         "  Me   Me   CH                                     1.851                                                                             "  "          "         Me OMe  OMe  CH                                     1.852                                                                             "  "          "         "  OMe  Me   N                                      1.853                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.854                                                                             "  "          "         "  OMe  Me   N                                      1.855                                                                             "  "          "         "  Me   Me   CH                                     1.856                                                                             "  "          "         Me OMe  Me   N                                      1.857                                                                             n-Pr                                                                              CSNHMe     CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.858                                                                             "  "          "         "  "    Cl   CH                                     1.859                                                                             "  "          "         "  Me   Me   CH                                     1.860                                                                             "  "          "         "  OMe  Me   N                                      1.861                                                                             "  "          "         Me OMe  OMe  CH                                     1.862                                                                             "  "          "         "  OMe  Me   N                                      1.863                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      1.864                                                                             "  "          "         "  "    OMe  CH                                     1.865                                                                             "  "          "         "  Me   Me   CH                                     1.866                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     1.867                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.868                                                                             "  "          "         "  OMe  Me   N                                      1.869                                                                             "  "          "         "  Me   Me   CH                                     1.870                                                                             "  "          "         "  Cl   OMe  N                                      1.871                                                                             "  "          "         Me OMe  Me   N                                      1.872                                                                             "  "          "         "  "    OMe  CH                                     1.873                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.874                                                                             "  "          "         "  "    Cl   CH                                     1.875                                                                             "  "          "         "  Me   Me   CH                                     1.876                                                                             "  "          "         "  OMe  Me   N                                      1.877                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.878                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.879                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    "                                      1.880                                                                             Me CSNHEt     CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.881                                                                             "  "          "         "  "    OMe  N                                      1.882                                                                             "  "          "         "  "    Me   N                                      1.883                                                                             "  "          "         "  "    "    CH                                     1.884                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.885                                                                             "  "          "         "  Me   Me   CH                                     1.886                                                                             "  "          "         "  "    "    N                                      1.887                                                                             "  "          "         "  Cl   OMe  CH                                     1.888                                                                             "  "          "         Me OMe  OMe  CH                                     1.889                                                                             "  "          "         "  "    Me   N                                      1.890                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.891                                                                             "  "          "         "  "    Cl   CH                                     1.892                                                                             "  "          "         "  Me   Me   CH                                     1.893                                                                             "  "          "         "  OMe  Me   N                                      1.894                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.895                                                                             "  "          "         Me OMe  OMe  CH                                     1.896                                                                             "  "          "         "  OMe  Me   N                                      1.897                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.898                                                                             "  "          "         "  "    "    N                                      1.899                                                                             "  "          "         "  OMe  Me   N                                      1.900                                                                             "  "          "         "  Me   Me   CH                                     1.901                                                                             "  "          "         "  OMe  Cl   CH                                     1.902                                                                             "  "          "         Me Me   OMe  N                                      1.903                                                                             "  "          "         "  OMe  OMe  CH                                     1.904                                                                             Me CSNHEt     CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.905                                                                             "  "          "         "  "    "    N                                      1.906                                                                             "  "          "         "  OMe  Me   N                                      1.907                                                                             "  "          "         "  OMe  Cl   CH                                     1.908                                                                             "  "          "         "  Me   Me   CH                                     1.909                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      1.910                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      1.911                                                                             "  "          "         "  OMe  OMe  CH                                     1.912                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     1.913                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.914                                                                             "  "          "         H  OMe  Me   N                                      1.915                                                                             "  "          "         "  Me   Me   CH                                     1.916                                                                             "  "          "         "  Cl   OMe  CH                                     1.917                                                                             "  "          "         Me OMe  OMe  CH                                     1.918                                                                             "  "          "         "  OMe  Me   N                                      1.919                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.920                                                                             "  "          "         "  "    Me   CH                                     1.921                                                                             "  "          "         "  Cl   OMe  CH                                     1.922                                                                             "  "          "         "  OMe  Me   N                                      1.923                                                                             "  "          "         Me OMe  OMe  CH                                     1.924                                                                             "  "          "         "  "    Me   N                                      1.925                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.926                                                                             "  "          "         "  OMe  Me   N                                      1.927                                                                             "  "          "         "  OMe  Cl   CH                                     1.928                                                                             "  "          "         "  Me   Me   CH                                     1.929                                                                             "  "          "         Me OMe  OMe  CH                                     1.930                                                                             "  "          "         "  OMe  Me   N                                      1.931                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.932                                                                             "  "          "         "  OMe  Me   N                                      1.933                                                                             "  "          "         "  Me   Me   CH                                     1.934                                                                             "  "          "         Me OMe  Me   N                                      1.935                                                                             n-Pr                                                                              CSNHEt     CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.936                                                                             "  "          "         "  "    Cl   CH                                     1.937                                                                             "  "          "         "  Me   Me   CH                                     1.938                                                                             "  "          "         "  OMe  Me   N                                      1.939                                                                             "  "          "         Me OMe  OMe  CH                                     1.940                                                                             "  "          "         "  OMe  Me   N                                      1.941                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      1.942                                                                             "  "          "         "  "    OMe  CH                                     1.943                                                                             "  "          "         "  Me   Me   CH                                     1.944                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     1.945                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.946                                                                             "  "          "         "  OMe  Me   N                                      1.947                                                                             "  "          "         "  Me   Me   CH                                     1.948                                                                             "  "          "         "  Cl   OMe  N                                      1.949                                                                             "  "          "         Me OMe  Me   N                                      1.950                                                                             "  "          "         "  "    OMe  CH                                     1.951                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.952                                                                             "  "          "         "  "    Cl   CH                                     1.953                                                                             "  "          "         "  Me   Me   CH                                     1.954                                                                             "  "          "         "  OMe  Me   N                                      1.955                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.956                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     1.957                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     1.958                                                                             Me CSNH-n-Pr  CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.959                                                                             "  "          "         "  "    OMe  N                                      1.960                                                                             "  "          "         "  "    Me   N                                      1.961                                                                             "  "          "         "  "    "    CH                                     1.962                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.963                                                                             "  "          "         "  Me   Me   CH                                     1.964                                                                             "  "          "         "  "    "    N                                      1.965                                                                             "  "          "         "  Cl   OMe  CH                                     1.966                                                                             "  "          "         Me OMe  OMe  CH                                     1.967                                                                             "  "          "         "  "    Me   N                                      1.968                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.969                                                                             "  "          "         "  "    Cl   CH                                     1.970                                                                             "  "          "         "  Me   Me   CH                                     1.971                                                                             "  "          "         "  OMe  Me   N                                      1.972                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      1.973                                                                             "  "          "         Me OMe  OMe  CH                                     1.974                                                                             "  "          "         "  OMe  Me   N                                      1.975                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     1.976                                                                             "  "          "         "  "    "    N                                      1.977                                                                             "  "          "         "  OMe  Me   N                                      1.978                                                                             "  "          "         "  Me   Me   CH                                     1.979                                                                             "  "          "         "  OMe  Cl   CH                                     1.980                                                                             "  "          "         Me Me   OMe  N                                      1.981                                                                             "  "          "         "  OMe  OMe  CH                                     1.982                                                                             Me CSNH-n-Pr  CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     1.983                                                                             "  "          "         "  "    "    N                                      1.984                                                                             "  "          "         "  OMe  Me   N                                      1.985                                                                             "  "          "         "  OMe  Cl   CH                                     1.986                                                                             "  "          "         "  Me   Me   CH                                     1.987                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      1.988                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      1.989                                                                             "  "          "         "  OMe  OMe  CH                                     1.990                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     1.991                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     1.992                                                                             "  "          "         H  OMe  Me   N                                      1.993                                                                             "  "          "         "  Me   Me   CH                                     1.994                                                                             "  "          "         "  Cl   OMe  CH                                     1.995                                                                             "  "          "         Me OMe  OMe  CH                                     1.996                                                                             "  "          "         "  OMe  Me   N                                      1.997                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     1.998                                                                             "  "          "         "  OMe  Me   CH                                     1.999                                                                             "  "          "         "  Cl   OMe  CH                                     2.000                                                                             "  "          "         "  OMe  Me   N                                      2.001                                                                             "  "          "         Me OMe  OMe  CH                                     2.002                                                                             "  "          "         "  "    Me   N                                      2.003                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.004                                                                             "  "          "         "  OMe  Me   N                                      2.005                                                                             "  "          "         "  OMe  Cl   CH                                     2.006                                                                             "  "          "         "  Me   Me   CH                                     2.007                                                                             "  "          "         Me OMe  OMe  CH                                     2.008                                                                             "  "          "         "  OMe  Me   N                                      2.009                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     2.010                                                                             "  "          "         "  OMe  Me   N                                      2.011                                                                             "  "          "         "  Me   Me   CH                                     2.012                                                                             "  "          "         Me OMe  Me   N                                      2.013                                                                             n-Pr                                                                              CSNH-n-Pr  CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.014                                                                             "  "          "         "  "    Cl   CH                                     2.015                                                                             "  "          "         "  Me   Me   CH                                     2.016                                                                             "  "          "         "  OMe  Me   N                                      2.017                                                                             "  "          "         Me OMe  OMe  CH                                     2.018                                                                             "  "          "         "  OMe  Me   N                                      2.019                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      2.020                                                                             "  "          "         "  "    OMe  CH                                     2.021                                                                             "  "          "         "  Me   Me   CH                                     2.022                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     2.023                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  "    "    CH                                     2.024                                                                             "  "          "         "  "    Me   N                                      2.025                                                                             "  "          "         "  Me   Me   CH                                     2.026                                                                             "  "          "         "  Cl   OMe  N                                      2.027                                                                             "  "          "         Me OMe  Me   N                                      2.028                                                                             "  "          "         "  "    OMe  CH                                     2.029                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.030                                                                             "  "          "         "  "    Cl   CH                                     2.031                                                                             "  "          "         "  Me   Me   CH                                     2.032                                                                             "  "          "         "  OMe  Me   N                                      2.033                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.034                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     2.035                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     2.036                                                                             Me CSNH-i-Pr  CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.037                                                                             "  "          "         "  "    OMe  N                                      2.038                                                                             "  "          "         "  "    Me   N                                      2.039                                                                             "  "          "         "  "    "    CH                                     2.040                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.041                                                                             "  "          "         "  Me   Me   CH                                     2.042                                                                             "  "          "         "  "    "    N                                      2.043                                                                             "  "          "         "  Cl   OMe  CH                                     2.044                                                                             "  "          "         Me OMe  OMe  CH                                     2.045                                                                             "  "          "         "  "    Me   N                                      2.046                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.047                                                                             "  "          "         "  "    Cl   CH                                     2.048                                                                             "  "          "         "  Me   Me   CH                                     2.049                                                                             "  "          "         "  OMe  Me   N                                      2.050                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.051                                                                             "  "          "         Me OMe  OMe  CH                                     2.052                                                                             "  "          "         "  OMe  Me   N                                      2.053                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.054                                                                             "  "          "         "  "    "    N                                      2.055                                                                             "  "          "         "  OMe  Me   N                                      2.056                                                                             "  "          "         "  Me   Me   CH                                     2.057                                                                             "  "          "         "  OMe  Cl   CH                                     2.058                                                                             "  "          "         Me Me   OMe  N                                      2.059                                                                             "  "          "         "  OMe  OMe  CH                                     2.060                                                                             Me CSNH-i-Pr  CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     2.061                                                                             "  "          "         "  "    "    N                                      2.062                                                                             "  "          "         "  OMe  Me   N                                      2.063                                                                             "  "          "         "  OMe  Cl   CH                                     2.064                                                                             "  "          "         "  Me   Me   CH                                     2.065                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      2.066                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      2.067                                                                             "  "          "         "  OMe  OMe  CH                                     2.068                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     2.069                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.070                                                                             "  "          "         H  OMe  Me   N                                      2.071                                                                             "  "          "         "  Me   Me   CH                                     2.072                                                                             "  "          "         "  Cl   OMe  CH                                     2.073                                                                             "  "          "         Me OMe  OMe  CH                                     2.074                                                                             "  "          "         "  OMe  Me   N                                      2.075                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.076                                                                             "  "          "         "  OMe  Me   CH                                     2.077                                                                             "  "          "         "  Cl   OMe  CH                                     2.078                                                                             "  "          "         "  OMe  Me   N                                      2.079                                                                             "  "          "         Me OMe  OMe  CH                                     2.080                                                                             "  "          "         "  "    Me   N                                      2.081                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.082                                                                             "  "          "         "  OMe  Me   N                                      2.083                                                                             "  "          "         "  OMe  Cl   CH                                     2.084                                                                             "  "          "         "  Me   Me   CH                                     2.085                                                                             "  "          "         Me OMe  OMe  CH                                     2.086                                                                             "  "          "         "  OMe  Me   N                                      2.087                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     2.088                                                                             "  "          "         "  OMe  Me   N                                      2.089                                                                             "  "          "         "  Me   Me   CH                                     2.090                                                                             "  "          "         Me OMe  Me   N                                      2.091                                                                             n-Pr                                                                              CSNH-i-Pr  CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.092                                                                             "  "          "         "  "    Cl   CH                                     2.093                                                                             "  "          "         "  Me   Me   CH                                     2.094                                                                             "  "          "         "  OMe  Me   N                                      2.095                                                                             "  "          "         Me OMe  OMe  CH                                     2.096                                                                             "  "          "         "  OMe  Me   N                                      2.097                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      2.098                                                                             "  "          "         "  "    OMe  CH                                     2.099                                                                             "  "          "         "  Me   Me   CH                                     2.100                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     2.101                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.102                                                                             "  "          "         "  OMe  Me   N                                      2.103                                                                             "  "          "         "  Me   Me   CH                                     2.104                                                                             "  "          "         "  Cl   OMe  N                                      2.105                                                                             "  "          "         Me OMe  Me   N                                      2.106                                                                             "  "          "         "  "    OMe  CH                                     2.107                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.108                                                                             "  "          "         "  "    Cl   CH                                     2.109                                                                             "  "          "         "  Me   Me   CH                                     2.110                                                                             "  "          "         "  OMe  Me   N                                      2.111                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.112                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     2.113                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     2.114                                                                             Me CSNH-allyl CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.115                                                                             "  "          "         "  "    OMe  N                                      2.116                                                                             "  "          "         "  "    Me   N                                      2.117                                                                             "  "          "         "  "    "    CH                                     2.118                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.119                                                                             "  "          "         "  Me   Me   CH                                     2.120                                                                             "  "          "         "  "    "    N                                      2.121                                                                             "  "          "         "  Cl   OMe  CH                                     2.122                                                                             "  "          "         Me OMe  OMe  CH                                     2.123                                                                             "  "          "         "  "    Me   N                                      2.124                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.125                                                                             "  "          "         "  "    Cl   CH                                     2.126                                                                             "  "          "         "  Me   Me   CH                                     2.127                                                                             "  "          "         "  OMe  Me   N                                      2.128                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.129                                                                             "  "          "         Me OMe  OMe  CH                                     2.130                                                                             "  "          "         "  OMe  Me   N                                      2.131                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.132                                                                             "  "          "         "  "    "    N                                      2.133                                                                             "  "          "         "  OMe  Me   N                                      2.134                                                                             "  "          "         "  Me   Me   CH                                     2.135                                                                             "  "          "         "  OMe  Cl   CH                                     2.136                                                                             "  "          "         Me Me   OMe  N                                      2.137                                                                             "  "          "         "  OMe  OMe  CH                                     2.138                                                                             Me CSNH-allyl CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     2.139                                                                             "  "          "         "  "    "    N                                      2.140                                                                             "  "          "         "  H    Me   N                                      2.141                                                                             "  "          "         "  OMe  Cl   CH                                     2.142                                                                             "  "          "         "  Me   Me   CH                                     2.143                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      2.144                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      2.145                                                                             "  "          "         "  OMe  OMe  CH                                     2.146                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     2.147                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.148                                                                             "  "          "         H  OMe  Me   N                                      2.149                                                                             "  "          "         "  Me   Me   CH                                     2.150                                                                             "  "          "         "  Cl   OMe  CH                                     2.151                                                                             "  "          "         Me OMe  OMe  CH                                     2.152                                                                             "  "          "         "  OMe  Me   N                                      2.153                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.154                                                                             "  "          "         "  OMe  Me   CH                                     2.155                                                                             "  "          "         "  Cl   OMe  CH                                     2.156                                                                             "  "          "         "  OMe  Me   N                                      2.157                                                                             "  "          "         Me OMe  OMe  CH                                     2.158                                                                             "  "          "         "  "    Me   N                                      2.159                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.160                                                                             "  "          "         "  OMe  Me   N                                      2.161                                                                             "  "          "         "  OMe  Cl   CH                                     2.162                                                                             "  "          "         "  Me   Me   CH                                     2.163                                                                             "  "          "         Me OMe  OMe  CH                                     2.164                                                                             "  "          "         "  OMe  Me   N                                      2.165                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     2.166                                                                             "  "          "         "  OMe  Me   N                                      2.167                                                                             "  "          "         "  Me   Me   CH                                     2.168                                                                             "  "          "         Me OMe  Me   N                                      2.169                                                                             n-Pr                                                                              CSNH-allyl CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.170                                                                             "  "          "         "  "    Cl   CH                                     2.171                                                                             "  "          "         "  Me   Me   CH                                     2.172                                                                             "  "          "         "  OMe  Me   N                                      2.173                                                                             "  "          "         Me OMe  OMe  CH                                     2.174                                                                             "  "          "         "  OMe  Me   N                                      2.175                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      2.176                                                                             "  "          "         "  "    OMe  CH                                     2.177                                                                             "  "          "         "  Me   Me   CH                                     2.178                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     2.179                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.180                                                                             "  "          "         "  OMe  Me   N                                      2.181                                                                             "  "          "         "  Me   Me   CH                                     2.182                                                                             "  "          "         "  Cl   OMe  N                                      2.183                                                                             "  "          "         Me OMe  Me   N                                      2.184                                                                             "  "          "         "  "    OMe  CH                                     2.185                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.186                                                                             "  "          "         "  "    Cl   CH                                     2.187                                                                             "  "          "         "  Me   Me   CH                                     2.188                                                                             "  "          "         "  OMe  Me   N                                      2.189                                                                             "  "          CO.sub.2 -Et                                                                             OMe                                                                               OMe  CH                                          2.190                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     2.191                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     2.192                                                                             Me CSNHCO.sub.2 Et                                                                           CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                                                               144-145° C.                   2.193                                                                             "  "          "         "  "    OMe  N                                      2.194                                                                             "  "          "         "  "    Me   N                                      2.195                                                                             "  "          "         "  "    "    CH                                     2.196                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.197                                                                             "  "          "         "  Me   Me   CH                                     2.198                                                                             "  "          "         "  "    "    N                                      2.199                                                                             "  "          "         "  Cl   OMe  CH                                     2.200                                                                             "  "          "         Me OMe  OMe  CH                                     2.201                                                                             "  "          "         "  "    Me   N                                      2.202                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.203                                                                             "  "          "         "  "    Cl   CH                                     2.204                                                                             "  "          "         "  Me   Me   CH                                     2.205                                                                             "  "          "         "  OMe  Me   N                                      2.206                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.207                                                                             "  "          "         M  OMe  OMe  CH                                     2.208                                                                             "  "          "         "  OMe  Me   N                                      2.209                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.210                                                                             "  "          "         "  "    "    N                                      2.211                                                                             "  "          "         "  OMe  OMe  N                                      2.212                                                                             "  "          "         "  Me   Me   CH                                     2.213                                                                             "  "          "         "  OMe  Cl   CH                                     2.214                                                                             "  "          "         Me Me   OMe  N                                      2.215                                                                             "  "          "         "  OMe  OMe  CH                                     2.216                                                                             Me CSNHCO.sub.2 Et                                                                           CO.sub.2 -i-Pr                                                                           N  OMe  OMe  CH                                     2.217                                                                             "  "          "         "  "    "    N                                      2.218                                                                             "  "          "         "  OMe  Me   N                                      2.219                                                                             "  "          "         "  OMe  Cl   CH                                     2.220                                                                             "  "          "         "  Me   Me   CH                                     2.221                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      2.222                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      2.223                                                                             "  "          "         "  OMe  OMe  CH                                     2.224                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     2.225                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.226                                                                             "  "          "         H  OMe  Me   N                                      2.227                                                                             "  "          "         "  Me   Me   CH                                     2.228                                                                             "  "          "         "  Cl   OMe  CH                                     2.229                                                                             "  "          "         Me OMe  OMe  CH                                     2.230                                                                             "  "          "         "  OMe  Me   N                                      2.231                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.232                                                                             "  "          "         "  OMe  Me   CH                                     2.233                                                                             "  "          "         "  Cl   OMe  CH                                     2.234                                                                             "  "          "         "  OMe  Me   N                                      2.235                                                                             "  "          "         Me OMe  OMe  CH                                     2.236                                                                             "  "          "         "  "    Me   N                                      2.237                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.238                                                                             "  "          "         "  OMe  Me   N                                      2.239                                                                             "  "          "         "  OMe  Cl   CH                                     2.240                                                                             "  "          "         "  Me   Me   CH                                     2.241                                                                             "  "          "         Me OMe  OMe  CH                                     2.242                                                                             "  "          "         "  OMe  Me   N                                      2.243                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     2.244                                                                             "  "          "         "  OMe  Me   N                                      2.245                                                                             "  "          "         "  Me   Me   CH                                     2.246                                                                             "  "          "         Me OMe  Me   N                                      2.247                                                                             n-Pr                                                                              CSNHCO.sub.2 Et                                                                           CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.248                                                                             "  "          "         "  "    Cl   CH                                     2.249                                                                             "  "          "         "  Me   Me   CH                                     2.250                                                                             "  "          "         "  OMe  Me   N                                      2.251                                                                             "  "          "         Me OMe  OMe  CH                                     2.252                                                                             "  "          "         "  OMe  Me   N                                      2.253                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      2.254                                                                             "  "          "         "  "    OMe  CH                                     2.255                                                                             "  "          "         "  Me   Me   CH                                     2.256                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     2.257                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.258                                                                             "  "          "         "  OMe  Me   N                                      2.259                                                                             "  "          "         "  Me   Me   CH                                     2.260                                                                             "  "          "         "  Cl   OMe  N                                      2.261                                                                             "  "          "         Me OMe  Me   N                                      2.262                                                                             "  "          "         "  "    OMe  CH                                     2.263                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.264                                                                             "  "          "         "  "    Cl   CH                                     2.265                                                                             "  "          "         "  Me   Me   CH                                     2.266                                                                             "  "          "         "  OMe  Me   N                                      2.267                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.268                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.269                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     2.270                                                                             Me SO.sub.2 NHMe                                                                             CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                                                               117-118° C.                   2.271                                                                             "  "          "         "  "    OMe  N                                      2.272                                                                             "  "          "         "  "    Me   N                                      2.273                                                                             "  "          "         "  "    "    CH                                     2.274                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.275                                                                             "  "          "         "  Me   Me   CH                                     2.276                                                                             "  "          "         "  "    "    N                                      2.277                                                                             "  "          "         "  Cl   OMe  CH                                     2.278                                                                             "  "          "         Me OMe  OMe  CH                                     2.279                                                                             "  "          "         "  "    Me   N                                      2.280                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.281                                                                             "  "          "         "  "    Cl   CH                                     2.282                                                                             "  "          "         "  Me   Me   CH                                     2.283                                                                             "  "          "         "  OMe  Me   N                                      2.284                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.285                                                                             "  "          "         Me OMe  OMe  CH                                     2.286                                                                             "  "          "         "  OMe  Me   N                                      2.287                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.288                                                                             "  "          "         "  "    "    N                                      2.289                                                                             "  "          "         "  OMe  Me   N                                      2.290                                                                             "  "          "         "  Me   Me   CH                                     2.291                                                                             "  "          "         "  OMe  Cl   CH                                     2.292                                                                             "  "          "         Me Me   OMe  N                                      2.293                                                                             "  "          "         "  OMe  OMe  CH                                     2.294                                                                             Me SO.sub.2 NHMe                                                                             CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     2.295                                                                             "  "          "         "  "    "    N                                      2.296                                                                             "  "          "         "  OMe  Me   N                                      2.297                                                                             "  "          "         "  Me   Me   CH                                     2.298                                                                             "  "          "         "  Me   Me   CH                                     2.299                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      2.300                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      2.301                                                                             "  "          "         "  OMe  OMe  CH                                     2.302                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     2.303                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.304                                                                             "  "          "         H  OMe  Me   N                                      2.305                                                                             "  "          "         "  Me   Me   CH                                     2.306                                                                             "  "          "         "  Cl   OMe  CH                                     2.307                                                                             "  "          "         Me OMe  OMe  CH                                     2.308                                                                             "  "          "         "  OMe  Me   N                                      2.309                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.310                                                                             "  "          "         "  OMe  Me   CH                                     2.311                                                                             "  "          "         "  Cl   OMe  CH                                     2.312                                                                             "  "          "         "  OMe  Me   N                                      2.313                                                                             "  "          "         Me OMe  OMe  CH                                     2.314                                                                             "  "          "         "  "    Me   N                                      2.315                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.316                                                                             "  "          "         "  OMe  Me   N                                      2.317                                                                             "  "          "         "  OMe  Cl   CH                                     2.318                                                                             "  "          "         "  Me   Me   CH                                     2.319                                                                             "  "          "         Me OMe  OMe  CH                                     2.320                                                                             "  "          "         "  OMe  Me   N                                      2.321                                                                             "  "          CO.sub. -i-Pr                                                                            H  OMe  OMe  CH                                     2.322                                                                             "  "          "         "  OMe  Me   N                                      2.323                                                                             "  "          "         "  Me   Me   CH                                     2.324                                                                             "  "          "         Me OMe  Me   N                                      2.325                                                                             n-Pr                                                                              SO.sub.2 NHMe                                                                             CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.326                                                                             "  "          "         "  "    Cl   CH                                     2.327                                                                             "  "          "         "  Me   Me   CH                                     2.328                                                                             "  "          "         "  OMe  Me   N                                      2.329                                                                             "  "          "         Me OMe  OMe  CH                                     2.330                                                                             "  "          "         "  OMe  Me   N                                      2.331                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      2.332                                                                             "  "          "         "  "    OMe  CH                                     2.333                                                                             "  "          "         "  Me   Me   CH                                     2.334                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     2.335                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.336                                                                             "  "          "         "  OMe  Me   N                                      2.337                                                                             "  "          "         "  Me   Me   CH                                     2.338                                                                             "  "          "         "  Cl   OMe  N                                      2.339                                                                             "  "          "         Me OMe  Me   N                                      2.340                                                                             "  "          "         "  "    OMe  CH                                     2.341                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.342                                                                             "  "          "         "  "    Cl   CH                                     2.343                                                                             "  "          "         "  Me   Me   CH                                     2.344                                                                             "  "          "         "  OMe  Me   N                                      2.345                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.346                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.347                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     2.348                                                                             Me SO.sub.2 NMe.sub.2                                                                        CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.349                                                                             "  "          "         "  "    OMe  N                                      2.350                                                                             "  "          "         "  "    Me   N                                      2.351                                                                             "  "          "         "  "    "    CH                                     2.352                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.353                                                                             "  "          "         "  Me   Me   CH                                     2.354                                                                             "  "          "         "  "    "    N                                      2.355                                                                             "  "          "         "  Cl   OMe  CH                                     2.356                                                                             "  "          "         Me OMe  OMe  CH                                     2.357                                                                             "  "          "         "  "    Me   N                                      2.358                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.359                                                                             "  "          "         "  "    Cl   CH                                     2.360                                                                             "  "          "         "  Me   Me   CH                                     2.361                                                                             "  "          "         "  OMe  Me   N                                      2.362                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.363                                                                             "  "          "         Me OMe  OMe  CH                                     2.364                                                                             "  "          "         "  OMe  Me   N                                      2.365                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.366                                                                             "  "          "         "  "    "    N                                      2.367                                                                             "  "          "         "  OMe  Me   N                                      2.368                                                                             "  "          "         "  Me   Me   CH                                     2.369                                                                             "  "          "         "  OMe  Cl   CH                                     2.370                                                                             "  "          "         Me Me   OMe  N                                      2.371                                                                             "  "          "         "  OMe  OMe  CH                                     2.372                                                                             Me SO.sub.2 NMe.sub.2                                                                        CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     2.373                                                                             "  "          "         "  "    "    N                                      2.374                                                                             "  "          "         "  OMe  Me   N                                      2.375                                                                             "  "          "         "  OMe  Cl   CH                                     2.376                                                                             "  "          "         "  Me   Me   CH                                     2.377                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      2.378                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      2.379                                                                             "  "          "         "  OMe  OMe  CH                                     2.380                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     2.381                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.382                                                                             "  "          "         H  OMe  Me   N                                      2.383                                                                             "  "          "         "  Me   Me   CH                                     2.384                                                                             "  "          "         "  Cl   OMe  CH                                     2.385                                                                             "  "          "         Me OMe  OMe  CH                                     2.386                                                                             "  "          "         "  OMe  Me   N                                      2.387                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.388                                                                             "  "          "         "  OMe  Me   CH                                     2.389                                                                             "  "          "         "  Cl   OMe  CH                                     2.390                                                                             "  "          "         "  OMe  Me   N                                      2.391                                                                             "  "          "         Me OMe  OMe  CH                                     2.392                                                                             "  "          "         "  "    Me   N                                      2.393                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.394                                                                             "  "          "         "  OMe  Me   N                                      2.395                                                                             "  "          "         "  OMe  Cl   CH                                     2.396                                                                             "  "          "         "  Me   Me   CH                                     2.397                                                                             "  "          "         Me OMe  OMe  CH                                     2.398                                                                             "  "          "         "  OMe  Me   N                                      2.399                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     2.400                                                                             "  "          "         "  OMe  Me   N                                      2.401                                                                             "  "          "         "  Me   Me   CH                                     2.402                                                                             "  "          "         Me OMe  Me   N                                      2.403                                                                             n-Pr                                                                              SO.sub.2 NMe.sub.2                                                                        CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.404                                                                             "  "          "         "  "    Cl   CH                                     2.405                                                                             "  "          "         "  Me   Me   CH                                     2.406                                                                             "  "          "         "  OMe  Me   N                                      2.407                                                                             "  "          "         Me OMe  OMe  CH                                     2.408                                                                             "  "          "         "  OMe  Me   N                                      2.409                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  OMe  Me   N                                      2.410                                                                             "  "          "         "  "    OMe  CH                                     2.411                                                                             "  "          "         "  Me   Me   CH                                     2.412                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     2.413                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.414                                                                             "  "          "         "  OMe  Me   N                                      2.415                                                                             "  "          "         "  Me   Me   CH                                     2.416                                                                             "  "          "         "  Cl   OMe  N                                      2.417                                                                             "  "          "         Me OMe  Me   N                                      2.418                                                                             "  "          "         "  "    OMe  CH                                     2.419                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.420                                                                             "  "          "         "  "    Cl   CH                                     2.421                                                                             "  "          "         "  Me   Me   CH                                     2.422                                                                             "  "          "         "  OMe  Me   N                                      2.423                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.424                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.425                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     2.426                                                                             Me CHO                                                                                        ##STR22##                                                                               H  OMe  OMe  CH                                     2.427                                                                             "  "          "         H  OMe  Me   N                                      2.428                                                                             "  "          "         "  Me   Me   CH                                     2.429                                                                             "  COCH.sub.3 "         "  OMe  OMe  CH                                     2.430                                                                             "  "          "         "  OMe  Me   N                                      2.431                                                                             "  "          "         "  Me   Me   CH                                     2.432                                                                             "  COCH.sub.2 CH.sub.3                                                                       "         "  OMe  OMe  CH                                     2.433                                                                             Et CHO        "         "  "    "    CH                                     2.434                                                                             Pr "          "         "  "    "    CH                                     2.435                                                                             Et COCH.sub.3 "         "  "    "    CH                                     2.436                                                                             Pr "          "         "  "    "    CH                                     2.437                                                                             Et COCH.sub.2 CH.sub.3                                                                       "         "  "    "    CH                                     2.438                                                                             Me                                                                                 ##STR23## "         "  "    "    CH                                     2.439                                                                             Me CO.sub.2 Me                                                                               "         "  "    "    CH                                     2.440                                                                             Et "          "         "  "    "    CH                                     2.441                                                                             Pr "          "         "  "    "    CH                                     2.442                                                                             Me CONHEt     "         "  "    "    CH                                     2.443                                                                             Et "          "         "  "    "    CH                                     2.444                                                                             Pr "          "         "  "    "    CH                                     2.445                                                                             Me CHO                                                                                        ##STR24##                                                                               H  OMe  OMe  CH                                     2.446                                                                             "  "          "         H  OMe  Me   N                                      2.447                                                                             "  "          "         "  Me   Me   CH                                     2.448                                                                             "  COCH.sub.3 "         "  OMe  OMe  CH                                     2.449                                                                             "  "          "         "  OMe  Me   N                                      2.450                                                                             "  "          "         "  Me   Me   CH                                     2.451                                                                             "  COCH.sub.2 CH.sub.3                                                                       "         "  OMe  OMe  CH                                     2.452                                                                             Et CHO        "         "  "    "    CH                                     2.453                                                                             Pr "          "         "  "    "    CH                                     2.454                                                                             Et COCH.sub.3 "         "  "    "    CH                                     2.455                                                                             Pr "          "         "  "    "    CH                                     2.456                                                                             Et COCH.sub.2 CH.sub.3                                                                       "         "  "    "    CH                                     2.457                                                                             Me                                                                                 ##STR25## "         "  "    "    CH                                     2.458                                                                             Me CO.sub.2 Me                                                                               "         "  "    "    CH                                     2.459                                                                             Et "          "         "  "    "    CH                                     2.460                                                                             Pr "          "         "  "    "    CH                                     2.461                                                                             Me CONHEt     "         "  "    "    CH                                     2.462                                                                             Et "          "         "  "    "    CH                                     2.463                                                                             Pr "          "         "  "    "    CH                                     2.464                                                                             Me CHO        CO.sub.2 NCHMe.sub.2                                                                     H  OMe  OMe  CH                                     2.465                                                                             "  "          "         H  OMe  Me   N                                      2.466                                                                             "  "          "         "  Me   Me   CH                                     2.467                                                                             "  COCH.sub.3 "         "  OMe  OMe  CH                                     2.468                                                                             "  "          "         "  OMe  Me   N                                      2.469                                                                             "  "          "         "  Me   Me   CH                                     2.470                                                                             "  COCH.sub.2 CH.sub.3                                                                       "         "  OMe  OMe  CH                                     2.471                                                                             Et CHO        "         "  "    "    CH                                     2.472                                                                             Pr "          "         "  "    "    CH                                     2.473                                                                             Et COCH.sub.3 "         "  "    "    CH                                     2.474                                                                             Pr "          "         "  "    "    CH                                     2.475                                                                             Et COCH.sub.2 CH.sub.3                                                                       "         "  "    "    CH                                     2.476                                                                             Me                                                                                 ##STR26## "         "  "    "    CH                                     2.477                                                                             Me CO.sub.2 Me                                                                               "         "  "    "    CH                                     2.478                                                                             Et "          "         "  "    "    CH                                     2.479                                                                             Pr "          "         "  "    "    CH                                     2.480                                                                             Me CONHEt     "         "  "    "    CH                                     2.481                                                                             Et "          "         "  "    "    CH                                     2.482                                                                             Pr "          "         "  "    "    CH                                     2.483                                                                             Me CHO        CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                            H  OMe  OMe  CH                                     2.484                                                                             "  "          "         "  OMe  Me   N                                      2.485                                                                             "  "          "         "  Me   Me   CH                                     2.486                                                                             "  COCH.sub.3 "         "  OMe  OMe  CH                                     2.487                                                                             "  "          "         "  OMe  Me   N                                      2.488                                                                             "  "          "         "  Me   Me   CH                                     2.489                                                                             "  COCH.sub.2 CH.sub.3                                                                       "         "  OMe  OMe  CH                                     2.490                                                                             Et CHO        "         "  "    "    "                                      2.491                                                                             Pr "          "         "  "    "    "                                      2.492                                                                             Et COCH.sub.3 "         "  "    "    "                                      2.493                                                                             Pr "          "         "  "    "    "                                      2.494                                                                             Et COCH.sub.2 CH.sub.3                                                                       "         "  "    "    "                                      2.495                                                                             Me                                                                                 ##STR27## "         "  "    "    "                                      2.496                                                                             Me CO.sub.2 Me                                                                               "         "  "    "    "                                      2.497                                                                             Et "          "         "  "    "    "                                      2.498                                                                             Pr "          "         "  "    "    "                                      2.499                                                                             Me CONHEt     "         "  "    "    "                                      2.500                                                                             Et "          "         "  "    "    "                                      2.501                                                                             Pr "          "         "  "    "    "                                      2.502                                                                             Me CHO        CO.sub.2 (CH.sub.2).sub.2 OMe                                                            H  OMe  OMe  CH                                     2.503                                                                             "  "          "         H  OMe  Me   N                                      2.504                                                                             "  "          "         "  Me   Me   CH                                     2.505                                                                             "  COCH.sub.3 "         "  OMe  OMe  CH                                     2.506                                                                             "  "          "         "  OMe  Me   N                                      2.507                                                                             "  "          "         "  Me   Me   CH                                     2.508                                                                             "  COCH.sub.2 CH.sub.3                                                                       "         "  OMe  OMe  CH                                     2.509                                                                             Et CHO        "         "  "    "    "                                      2.510                                                                             Pr "          "         "  "    "    "                                      2.511                                                                             Et COCH.sub.3 "         "  "    "    "                                      2.512                                                                             Pr "          "         "  "    "    "                                      2.513                                                                             Et COCH.sub.2 CH.sub.3                                                                       "         "  "    "    "                                      2.514                                                                             Me                                                                                 ##STR28## "         "  "    "    "                                      2.515                                                                             Me CO.sub.2 Me                                                                               "         "  "    "    "                                      2.516                                                                             Et "          "         "  "    "    "                                      2.517                                                                             Pr "          "         "  "    "    "                                      2.518                                                                             Me CONHEt     "         "  "    "    "                                      2.519                                                                             Et "          "         "  "    "    "                                      2.520                                                                             Pr "          "         "  "    "    "                                      2.521                                                                             Me CHO        CO.sub.2 CH.sub.2 CCl.sub.3                                                              H  OMe  OMe  CH                                     2.522                                                                             "  "          "         H  OMe  Me   N                                      2.523                                                                             "  "          "         "  Me   Me   CH                                     2.524                                                                             "  COCH.sub.3 "         "  OMe  OMe  CH                                     2.525                                                                             "  "          "         "  OMe  Me   N                                      2.526                                                                             "  "          "         "  Me   Me   CH                                     2.527                                                                             "  COCH.sub.2 CH.sub.3                                                                       "         "  OMe  OMe  CH                                     2.528                                                                             Et CHO        "         "  "    "    "                                      2.529                                                                             Pr "          "         "  "    "    "                                      2.530                                                                             Et COCH.sub.3 "         "  "    "    "                                      2.531                                                                             Pr "          "         "  "    "    "                                      2.532                                                                             Et COCH.sub.2 CH.sub.3                                                                       "         "  "    "    "                                      2.533                                                                             Me                                                                                 ##STR29## "         "  "    "    "                                      2.534                                                                             Me CO.sub.2 Me                                                                               "         "  "    "    "                                      2.535                                                                             Et "          "         "  "    "    "                                      2.536                                                                             Pr "          "         "  "    "    "                                      2.537                                                                             Me CONHEt     "         "  "    "    "                                      2.538                                                                             Et "          "         "  "    "    "                                      2.539                                                                             Pr "          "         "  "    "    "                                      2.540                                                                             Me CHO        CO.sub.2 CH.sub.2 CCH                                                                    H  OMe  OMe  CH                                     2.541                                                                             "  "          "         H  OMe  Me   N                                      2.542                                                                             "  "          "         "  Me   Me   CH                                     2.543                                                                             "  COCH.sub.3 "         "  OMe  OMe  CH                                     2.544                                                                             "  "          "         "  OMe  Me   N                                      2.545                                                                             "  "          "         "  Me        CH                                     2.546                                                                             "  COCH.sub.2 CH.sub.3                                                                       "         "  OMe  OMe  CH                                     2.547                                                                             Et CHO        "         "  "    "    "                                      2.548                                                                             Pr "          "         "  "    "    "                                      2.549                                                                             Et COCH.sub.3 "         "  "    "    "                                      2.550                                                                             Pr "          "         "  "    "    "                                      2.551                                                                             Et COCH.sub.2 CH.sub.3                                                                       "         "  "    "    "                                      2.552                                                                             Me                                                                                 ##STR30## "         "  "    "    "                                      2.553                                                                             Me CO.sub.2 Me                                                                               "         "  "    "    "                                      2.554                                                                             Et "          "         "  "    "    "                                      2.555                                                                             Pr "          "         "  "    "    "                                      2.556                                                                             Me CONHEt     "         "  "    "    "                                      2.557                                                                             Et "          "         "  "    "    "                                      2.558                                                                             Pr "          "         "  "    "    "                                      2.559                                                                             Me SO.sub.2 Et                                                                               CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     2.560                                                                             "  "          "         "  "    OMe  N                                      2.561                                                                             "  "          "         "  "    Me   N                                      2.562                                                                             "  "          "         "  "    "    CH                                     2.563                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.564                                                                             "  "          "         "  Me   Me   CH                                     2.565                                                                             "  "          "         "  "    "    N                                      2.566                                                                             "  "          "         "  Cl   OMe  CH                                     2.567                                                                             "  "          "         Me OMe  OMe  CH                                     2.568                                                                             "  "          "         "  "    Me   N                                      2.569                                                                             "  "          CO.sub.2 Et                                                                              H  OMe  OMe  CH                                     2.570                                                                             "  "          "         "  "    Cl   CH                                     2.571                                                                             "  "          "         "  Me   Me   CH                                     2.572                                                                             "  "          "         "  OMe  Me   N                                      2.573                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.574                                                                             "  "          "         Me OMe  OMe  CH                                     2.575                                                                             "  "          "         "  OMe  Me   N                                      2.576                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.577                                                                             "  "          "         "  "    "    N                                      2.578                                                                             "  "          "         "  OMe  Me   N                                      2.579                                                                             "  "          "         "  Me   Me   CH                                     2.580                                                                             "  "          "         "  OMe  Cl   CH                                     2.581                                                                             "  "          "         Me Me   OMe  N                                      2.582                                                                             "  "          "         "  OMe  OMe  CH                                     2.583                                                                             Me SO.sub.2 Et                                                                               CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     2.584                                                                             "  "          "         "  "    "    N                                      2.585                                                                             "  "          "         "  OMe  Me   N                                      2.586                                                                             "  "          "         "  OMe  Cl   CH                                     2.587                                                                             "  "          "         "  Me   Me   CH                                     2.588                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      2.589                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      2.590                                                                             "  "          "         "  OMe  OMe  CH                                     2.591                                                                             Me "          CO.sub.2 -allyl                                                                          H  OMe  OMe  CH                                     2.592                                                                             Et "          CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     2.593                                                                             "  "          "         H  OMe  Me   N                                      2.594                                                                             "  "          "         "  Me   Me   CH                                     2.595                                                                             "  "          "         "  Cl   OMe  CH                                     2.596                                                                             "  "          "         Me OMe  OMe  CH                                     2.597                                                                             "  "          "         "  OMe  Me   N                                      2.598                                                                             "  "          CO.sub.2 Et                                                                              H  OMe  OMe  CH                                     2.599                                                                             "  "          "         "  OMe  Me   CH                                     2.600                                                                             "  "          "         "  Cl   OMe  CH                                     2.601                                                                             "  "          "         "  OMe  Me   N                                      2.602                                                                             "  "          "         Me OMe  OMe  CH                                     2.603                                                                             "  "          "         "  "    Me   N                                      2.604                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.605                                                                             "  "          "         "  OMe  Me   N                                      2.606                                                                             "  "          "         "  OMe  Cl   CH                                     2.607                                                                             "  "          "         "  Me   Me   CH                                     2.608                                                                             "  "          "         Me OMe  OMe  CH                                     2.609                                                                             "  "          "         "  OMe  Me   N                                      2.610                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     2.611                                                                             "  "          "         "  OMe  Me   N                                      2.612                                                                             "  "          "         "  Me   Me   CH                                     2.613                                                                             "  "          "         Me OMe  Me   N                                      2.614                                                                             n-Pr                                                                              SO.sub.2 Et                                                                               CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     2.615                                                                             "  "          "         "  "    Cl   CH                                     2.616                                                                             "  "          "         "  Me   Me   CH                                     2.617                                                                             "  "          "         "  OMe  Me   N                                      2.618                                                                             "  "          "         Me OMe  OMe  CH                                     2.619                                                                             "  "          "         "  OMe  Me   N                                      2.620                                                                             n-Pr                                                                              "          CO.sub.2 Et                                                                              H  "    "    N                                      2.621                                                                             "  "          "         "  "    OMe  CH                                     2.622                                                                             "  "          "         "  Me   Me   CH                                     2.623                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     2.624                                                                             i-Pr                                                                              "          CO.sub.2 Me                                                                              H  "    "    CH                                     2.625                                                                             "  "          "         "  "    Me   N                                      2.626                                                                             "  "          "         "  Me   Me   CH                                     2.627                                                                             "  "          "         "  Cl   OMe  N                                      2.628                                                                             "  "          "         Me OMe  Me   N                                      2.629                                                                             "  "          "         "  "    OMe  CH                                     2.630                                                                             Allyl                                                                             "          CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     2.631                                                                             "  "          "         "  "    Cl   CH                                     2.632                                                                             "  "          "         "  Me   Me   CH                                     2.633                                                                             "  "          "         "  OMe  Me   N                                      2.634                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.635                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.636                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     2.637                                                                             Me SO.sub.2 CH.sub.2 Cl                                                                      CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.638                                                                             "  "          "         "  "    OMe  N                                      2.639                                                                             "  "          "         "  "    Me   N                                      2.640                                                                             "  "          "         "  "    "    CH                                     2.641                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.642                                                                             "  "          "         "  Me   Me   CH                                     2.643                                                                             "  "          "         "  "    "    N                                      2.644                                                                             "  "          "         "  Cl   OMe  CH                                     2.645                                                                             "  "          "         Me OMe  OMe  CH                                     2.646                                                                             "  "          "         "  "    Me   N                                      2.647                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.648                                                                             "  "          "         "  "    Cl   CH                                     2.649                                                                             "  "          "         "  Me   Me   CH                                     2.650                                                                             "  "          "         "  OMe  Me   N                                      2.651                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.652                                                                             "  "          "         Me OMe  OMe  CH                                     2.653                                                                             "  "          "         "  OMe  Me   N                                      2.654                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.655                                                                             "  "          "         "  "    "    N                                      2.656                                                                             "  "          "         "  OMe  Me   N                                      2.657                                                                             "  "          "         "  Me   Me   CH                                     2.658                                                                             "  "          "         "  OMe  Cl   CH                                     2.659                                                                             "  "          "         Me Me   OMe  N                                      2.660                                                                             "  "          "         "  OMe  OMe  CH                                     2.661                                                                             Me SO.sub.2 CH.sub.2 Cl                                                                      CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     2.662                                                                             "  "          "         "  "    "    N                                      2.663                                                                             "  "          "         "  OMe  Me   N                                      2.664                                                                             "  "          "         "  OMe  Cl   CH                                     2.665                                                                             "  "          "         "  Me   Me   CH                                     2.666                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      2.667                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      2.668                                                                             "  "          "         "  OMe  OMe  CH                                     2.669                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     2.670                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.671                                                                             "  "          "         H  OMe  Me   N                                      2.672                                                                             "  "          "         "  Me   Me   CH                                     2.673                                                                             "  "          "         "  Cl   OMe  CH                                     2.674                                                                             "  "          "         Me OMe  OMe  CH                                     2.675                                                                             "  "          "         "  OMe  Me   N                                      2.676                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.677                                                                             "  "          "         "  OMe  Me   CH                                     2.678                                                                             "  "          "         "  Cl   OMe  CH                                     2.679                                                                             "  "          "         "  OMe  Me   N                                      2.680                                                                             "  "          "         Me OMe  OMe  CH                                     2.681                                                                             "  "          "         "  "    Me   N                                      2.682                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.683                                                                             "  "          "         "  OMe  Me   N                                      2.684                                                                             "  "          "         "  OMe  Cl   CH                                     2.685                                                                             "  "          "         "  Me   Me   CH                                     2.686                                                                             "  "          "         Me OMe  OMe  CH                                     2.687                                                                             "  "          "         "  "    Me   N                                      2.688                                                                             "  "          CO.sub.2 i-Pr                                                                            H  OMe  OMe  CH                                     2.689                                                                             "  "          "         "  OMe  Me   N                                      2.690                                                                             "  "          "         "  Me   Me   CH                                     2.691                                                                             "  "          "         Me OMe  Me   N                                      2.692                                                                             n-Pr                                                                              SO.sub.2 CH.sub.2 Cl                                                                      CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.693                                                                             "  "          "         "  "    Cl   CH                                     2.694                                                                             "  "          "         "  Me   Me   CH                                     2.695                                                                             "  "          "         "  OMe  Me   N                                      2.696                                                                             "  "          "         Me OMe  OMe  CH                                     2.697                                                                             "  "          "         "  "    Me   N                                      2.698                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      2.699                                                                             "  "          "         "  "    OMe  CH                                     2.700                                                                             "  "          "         "  Me   Me   CH                                     2.701                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     2.702                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.703                                                                             "  "          "         "  OMe  Me   N                                      2.704                                                                             "  "          "         "  Me   Me   CH                                     2.705                                                                             "  "          "         "  Cl   OMe  N                                      2.706                                                                             "  "          "         Me OMe  Me   N                                      2.707                                                                             "  "          "         "  "    OMe  CH                                     2.708                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.709                                                                             "  "          "         "  "    Cl   CH                                     2.710                                                                             "  "          "         "  Me   Me   CH                                     2.711                                                                             "  "          "         "  OMe  Me   N                                      2.712                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.713                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     2.714                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     2.715                                                                             Me SO.sub.2 CH.sub.3                                                                         CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                                                               119° C.                       2.716                                                                             "  "          "         "  "    OMe  N                                      2.717                                                                             "  "          "         "  "    Me   N                                      2.718                                                                             "  "          "         "  "    "    CH                                     2.719                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.720                                                                             "  "          "         "  Me   Me   CH                                     2.721                                                                             "  "          "         "  "    "    N                                      2.722                                                                             "  "          "         "  Cl   OMe  CH                                     2.723                                                                             "  "          "         Me OMe  OMe  CH                                     2.724                                                                             "  "          "         "  "    Me   N                                      2.725                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.726                                                                             "  "          "         "  "    Cl   CH                                     2.727                                                                             "  "          "         "  Me   Me   CH                                     2.728                                                                             "  "          "         "  OMe  Me   N                                      2.729                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.730                                                                             "  "          "         Me OMe  OMe  CH                                     2.731                                                                             "  "          "         "  OMe  Me   N                                      2.732                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.733                                                                             "  "          "         "  "    "    N                                      2.734                                                                             "  "          "         "  OMe  Me   N                                      2.735                                                                             "  "          "         "  Me   Me   CH                                     2.736                                                                             "  "          "         "  OMe  Cl   CH                                     2.737                                                                             "  "          "         Me Me   OMe  N                                      2.738                                                                             "  "          "         "  OMe  OMe  CH                                     2.739                                                                             Me SO.sub.2 Me                                                                               CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     2.740                                                                             "  "          "         "  "    "    N                                      2.741                                                                             "  "          "         "  OMe  Me   N                                      2.742                                                                             "  "          "         "  OMe  Cl   CH                                     2.743                                                                             "  "          "         "  Me   Me   CH                                     2.744                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      2.745                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      2.746                                                                             "  "          "         "  OMe  OMe  CH                                     2.747                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     2.748                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.749                                                                             "  "          "         H  OMe  Me   N                                      2.750                                                                             "  "          "         "  Me   Me   CH                                     2.751                                                                             "  "          "         "  Cl   OMe  CH                                     2.752                                                                             "  "          "         Me OMe  OMe  CH                                     2.753                                                                             "  "          "         "  OMe  Me   N                                      2.754                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.755                                                                             "  "          "         "  OMe  Me   CH                                     2.756                                                                             "  "          "         "  Cl   OMe  CH                                     2.757                                                                             "  "          "         "  OMe  Me   N                                      2.758                                                                             "  "          "         Me OMe  OMe  CH                                     2.759                                                                             "  "          "         "  "    Me   N                                      2.760                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.761                                                                             "  "          "         "  OMe  Me   N                                      2.762                                                                             "  "          "         "  OMe  Cl   CH                                     2.763                                                                             "  "          "         "  Me   Me   CH                                     2.764                                                                             "  "          "         Me OMe  OMe  CH                                     2.765                                                                             "  "          "         "  OMe  Me   N                                      2.766                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     2.767                                                                             "  "          "         "  OMe  Me   N                                      2.768                                                                             "  "          "         "  Me   Me   CH                                     2.769                                                                             "  "          "         Me OMe  Me   N                                      2.770                                                                             n-Pr                                                                              SO.sub.2 Me                                                                               CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.771                                                                             "  "          "         "  "    Cl   CH                                     2.772                                                                             "  "          "         "  Me   Me   CH                                     2.773                                                                             "  "          "         "  OMe  Me   N                                      2.774                                                                             "  "          "         Me OMe  OMe  CH                                     2.775                                                                             "  "          "         "  OMe  Me   N                                      2.776                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      2.777                                                                             "  "          "         "  "    OMe  CH                                     2.778                                                                             "  "          "         "  Me   Me   CH                                     2.779                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     2.780                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.781                                                                             "  "          "         "  OMe  Me   N                                      2.782                                                                             "  "          "         "  Me   Me   CH                                     2.783                                                                             "  "          "         "  Cl   OMe  N                                      2.784                                                                             "  "          "         Me OMe  Me   N                                      2.785                                                                             "  "          "         "  "    OMe  CH                                     2.786                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.787                                                                             "  "          "         "  "    Cl   CH                                     2.788                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.789                                                                             "  "          "         "  "    Cl   CH                                     2.790                                                                             "  "          "         "  Me   Me   CH                                     2.791                                                                             "  "          "         "  OMe  Me   N                                      2.792                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.793                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     2.794                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     2.795                                                                             Me CONH       CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                           CH.sub.2 CH.sub.2 Cl                                                     2.796                                                                             "  "          "         "  "    OMe  N                                      2.797                                                                             "  "          "         "  "    Me   N                                      2.798                                                                             "  "          "         "  "    "    CH                                     2.799                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.800                                                                             "  "          "         "  Me   Me   CH                                     2.801                                                                             "  "          "         "  "    "    N                                      2.802                                                                             "  "          "         "  Cl   OMe  CH                                     2.803                                                                             "  "          "         Me OMe  OMe  CH                                     2.804                                                                             "  "          "         "  "    Me   N                                      2.805                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.806                                                                             "  "          "         "  "    Cl   CH                                     2.807                                                                             "  "          "         "  Me   Me   CH                                     2.808                                                                             "  "          "         "  OMe  Me   N                                      2.809                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.810                                                                             "  "          "         Me OMe  OMe  CH                                     2.811                                                                             "  "          "         "  OMe  Me   N                                      2.812                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.813                                                                             "  "          "         "  "    "    N                                      2.814                                                                             "  "          "         "  OMe  Me   N                                      2.815                                                                             "  "          "         "  Me   Me   CH                                     2.816                                                                             "  "          "         "  OMe  Cl   CH                                     2.817                                                                             "  "          "         Me Me   OMe  N                                      2.818                                                                             "  "          "         "  OMe  OMe  CH                                     2.819                                                                             Me CO         CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                           NHCH.sub.2 CH.sub.2 Cl                                                   2.820                                                                             "  "          "         "  "    "    N                                      2.821                                                                             "  "          "         "  OMe  Me   N                                      2.822                                                                             "  "          "         "  OMe  Cl   CH                                     2.823                                                                             "  "          "         "  Me   Me   CH                                     2.824                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      2.825                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      2.826                                                                             "  "          "         "  OMe  OMe  CH                                     2.827                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     2.828                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.829                                                                             "  "          "         H  OMe  Me   N                                      2.830                                                                             "  "          "         "  Me   Me   CH                                     2.831                                                                             "  "          "         "  Cl   OMe  CH                                     2.832                                                                             "  "          "         Me OMe  OMe  CH                                     2.833                                                                             "  "          "         "  OMe  Me   N                                      2.834                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.835                                                                             "  "          "         "  OMe  Me   CH                                     2.836                                                                             "  "          "         "  Cl   OMe  CH                                     2.837                                                                             "  "          "         "  OMe  Me   N                                      2.838                                                                             "  "          "         Me OMe  OMe  CH                                     2.839                                                                             "  "          "         "  "    Me   N                                      2.840                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.841                                                                             "  "          "         H  OMe  Me   N                                      2.842                                                                             "  "          "         "  OMe  Cl   CH                                     2.843                                                                             "  "          "         "  Me   Me   CH                                     2.844                                                                             "  "          "         Me OMe  OMe  CH                                     2.845                                                                             "  "          "         "  OMe  Me   N                                      2.846                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     2.847                                                                             "  "          "         H  OMe  Me   N                                      2.848                                                                             "  "          "         "  Me   Me   CH                                     2.849                                                                             "  "          "         Me OMe  Me   N                                      2.850                                                                             n-Pr                                                                              CONH       CO.sub.2 Me                                                                              H  OMe  OMe  CH                                           CH.sub.2 CH.sub.2 Cl                                                     2.851                                                                             "  "          "         "  "    Cl   CH                                     2.852                                                                             "  "          "         "  Me   Me   CH                                     2.853                                                                             "  "          "         "  OMe  Me   N                                      2.854                                                                             "  "          "         Me OMe  OMe  CH                                     2.855                                                                             "  "          "         "  OMe  Me   N                                      2.856                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      2.857                                                                             "  "          "         "  "    OMe  CH                                     2.858                                                                             "  "          "         "  Me   Me   CH                                     2.859                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     2.860                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.861                                                                             "  "          "         "  OMe  Me   N                                      2.862                                                                             "  "          "         "  Me   Me   CH                                     2.863                                                                             "  "          "         "  Cl   OMe  N                                      2.864                                                                             "  "          "         Me OMe  Me   N                                      2.865                                                                             "  "          "         "  "    OMe  CH                                     2.866                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.867                                                                             "  "          "         "  "    Cl   CH                                     2.868                                                                             "  "          "         "  Me   Me   CH                                     2.869                                                                             "  "          "         "  OMe  Me   N                                      2.870                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.871                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     2.872                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     2.873                                                                             Me COOCH.sub.2 CCl.sub.3                                                                     CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.874                                                                             "  "          "         "  "    OMe  N                                      2.875                                                                             "  "          "         "  "    Me   N                                      2.876                                                                             "  "          "         "  "    "    CH                                     2.877                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.878                                                                             "  "          "         "  Me   Me   CH                                     2.879                                                                             "  "          "         "  "    "    N                                      2.880                                                                             "  "          "         "  Cl   OMe  CH                                     2.881                                                                             "  "          "         Me OMe  OMe  CH                                     2.882                                                                             "  "          "         "  "    Me   N                                      2.883                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.884                                                                             "  "          "         "  "    Cl   CH                                     2.885                                                                             "  "          "         "  Me   Me   CH                                     2.886                                                                             "  "          "         "  OMe  Me   N                                      2.887                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.888                                                                             "  "          "         Me OMe  OMe  CH                                     2.889                                                                             "  "          "         "  OMe  Me   N                                      2.890                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.891                                                                             "  "          "         "  "    "    N                                      2.892                                                                             "  "          "         "  OMe  Me   N                                      2.893                                                                             "  "          "         "  Me   Me   CH                                     2.894                                                                             "  "          "         "  OMe  Cl   CH                                     2.895                                                                             "  "          "         Me Me   OMe  N                                      2.896                                                                             "  "          "         "  OMe  OMe  CH                                     2.897                                                                             Me COOCH.sub.2 CCl.sub.3                                                                     CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     2.898                                                                             "  "          "         "  "    "    N                                      2.899                                                                             "  "          "         "  OMe  Me   N                                      2.900                                                                             "  "          "         "  OMe  Cl   CH                                     2.901                                                                             "  "          "         "  Me   Me   CH                                     2.902                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      2.903                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      2.904                                                                             "  "          "         "  OMe  OMe  CH                                     2.905                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     2.906                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.907                                                                             "  "          "         H  OMe  Me   N                                      2.908                                                                             "  "          "         "  Me   Me   CH                                     2.909                                                                             "  "          "         "  Cl   OMe  CH                                     2.910                                                                             "  "          "         Me OMe  OMe  CH                                     2.911                                                                             "  "          "         "  OMe  Me   N                                      2.912                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.913                                                                             "  "          "         "  OMe  Me   CH                                     2.914                                                                             "  "          "         "  Cl   OMe  CH                                     2.915                                                                             "  "          "         "  OMe  Me   N                                      2.916                                                                             "  "          "         Me OMe  OMe  CH                                     2.917                                                                             "  "          "         "  "    Me   N                                      2.918                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.919                                                                             "  "          "         "  OMe  Me   N                                      2.920                                                                             "  "          "         "  OMe  Cl   CH                                     2.921                                                                             "  "          "         "  Me   Me   CH                                     2.922                                                                             "  "          "         Me OMe  OMe  CH                                     2.923                                                                             "  "          "         "  OMe  Me   N                                      2.924                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     2.925                                                                             "  "          "         "  OMe  Me   N                                      2.926                                                                             "  "          "         "  Me   Me   CH                                     2.927                                                                             "  "          "         Me OMe  Me   N                                      2.928                                                                             n-Pr                                                                              COOCH.sub.2 CCl.sub.3                                                                     CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.929                                                                             "  "          "         "  "    Cl   CH                                     2.930                                                                             "  "          "         "  Me   Me   CH                                     2.931                                                                             "  "          "         "  OMe  Me   N                                      2.932                                                                             "  "          "         Me OMe  OMe  CH                                     2.933                                                                             "  "          "         "  OMe  Me   N                                      2.934                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  OMe  Me   N                                      2.935                                                                             "  "          "         "  "    OMe  CH                                     2.936                                                                             "  "          "         "  Me   Me   CH                                     2.937                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     2.938                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.939                                                                             "  "          "         "  OMe  Me   N                                      2.940                                                                             "  "          "         "  Me   Me   CH                                     2.941                                                                             "  "          "         "  Cl   OMe  N                                      2.942                                                                             "  "          "         Me OMe  Me   N                                      2.943                                                                             "  "          "         "  "    OMe  CH                                     2.944                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.945                                                                             "  "          "         "  "    Cl   CH                                     2.946                                                                             "  "          "         "  Me   Me   CH                                     2.947                                                                             "  "          "         "  OMe  Me   N                                      2.948                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.949                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.950                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     2.951                                                                             Me COCH.sub.2 Br                                                                             CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                                                               155-161                              2.952                                                                             "  "          "         "  "    OMe  N                                      2.953                                                                             "  "          "         "  "    Me   N                                      2.954                                                                             "  "          "         "  "    "    CH                                     2.955                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.956                                                                             "  "          "         "  Me   Me   CH                                     2.957                                                                             "  "          "         "  "    "    N                                      2.958                                                                             "  "          "         "  Cl   OMe  CH                                     2.959                                                                             "  "          "         Me OMe  OMe  CH                                     2.960                                                                             "  "          "         "  "    Me   N                                      2.961                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.962                                                                             "  "          "         "  "    Cl   CH                                     2.963                                                                             "  "          "         "  Me   Me   CH                                     2.964                                                                             "  "          "         "  OMe  Me   N                                      2.965                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      2.966                                                                             "  "          "         Me OMe  OMe  CH                                     2.967                                                                             "  "          "         "  OMe  Me   N                                      2.968                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.969                                                                             "  "          "         "  "    "    N                                      2.970                                                                             "  "          "         "  OMe  Me   N                                      2.971                                                                             "  "          "         "  Me   Me   CH                                     2.972                                                                             "  "          "         "  OMe  Cl   CH                                     2.973                                                                             "  "          "         Me Me   OMe  N                                      2.974                                                                             "  "          "         "  OMe  OMe  CH                                     2.975                                                                             Me COCH.sub.2 Br                                                                             CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     2.976                                                                             "  "          "         "  "    "    N                                      2.977                                                                             "  "          "         "  H    Me   N                                      2.978                                                                             "  "          "         "  OMe  Cl   CH                                     2.979                                                                             "  "          "         "  Me   Me   CH                                     2.980                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      2.981                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      2.982                                                                             "  "          "         "  OMe  OMe  CH                                     2.983                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     2.984                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     2.985                                                                             "  "          "         H  OMe  Me   N                                      2.986                                                                             "  "          "         "  Me   Me   CH                                     2.987                                                                             "  "          "         "  Cl   OMe  CH                                     2.988                                                                             "  "          "         Me OMe  OMe  CH                                     2.989                                                                             "  "          "         "  OMe  Me   N                                      2.990                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     2.991                                                                             "  "          "         "  OMe  Me   CH                                     2.992                                                                             "  "          "         "  Cl   OMe  CH                                     2.993                                                                             "  "          "         "  OMe  Me   N                                      2.994                                                                             "  "          "         Me OMe  OMe  CH                                     2.995                                                                             "  "          "         "  "    Me   N                                      2.996                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     2.997                                                                             "  "          "         "  OMe  Me   N                                      2.998                                                                             "  "          "         "  OMe  Cl   CH                                     2.999                                                                             "  "          "         "  Me   Me   CH                                     3.000                                                                             "  "          "         Me OMe  OMe  CH                                     3.001                                                                             "  "          "         "  OMe  Me   N                                      3.002                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     3.003                                                                             "  "          "         "  OMe  Me   N                                      3.004                                                                             "  "          "         "  Me   Me   CH                                     3.005                                                                             "  "          "         Me OMe  Me   N                                      3.006                                                                             n-Pr                                                                              COCH.sub.2 Br                                                                             CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.007                                                                             "  "          "         "  "    Cl   CH                                     3.008                                                                             "  "          "         "  Me   Me   CH                                     3.009                                                                             "  "          "         "  OMe  Me   N                                      3.010                                                                             "  "          "         Me OMe  OMe  CH                                     3.011                                                                             "  "          "         "  OMe  Me   N                                      3.012                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      3.013                                                                             "  "          "         "  "    OMe  CH                                     3.014                                                                             "  "          "         "  Me   Me   CH                                     3.015                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     3.016                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.017                                                                             "  "          "         "  OMe  Me   N                                      3.018                                                                             "  "          "         "  Me   Me   CH                                     3.019                                                                             "  "          "         "  Cl   OMe  N                                      3.020                                                                             "  "          "         Me OMe  Me   N                                      3.021                                                                             "  "          "         "  "    OMe  CH                                     3.022                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.023                                                                             "  "          "         "  "    Cl   CH                                     3.024                                                                             "  "          "         "  Me   Me   CH                                     3.025                                                                             "  "          "         "  OMe  Me   N                                      3.026                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     3.027                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     3.028                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     3.029                                                                             Me COCCl.sub.3                                                                               CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.030                                                                             "  "          "         "  "    OMe  N                                      3.031                                                                             "  "          "         "  "    Me   N                                      3.032                                                                             "  "          "         "  "    "    CH                                     3.033                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      3.034                                                                             "  "          "         "  Me   Me   CH                                     3.035                                                                             "  "          "         "  "    "    N                                      3.036                                                                             "  "          "         "  Cl   OMe  CH                                     3.037                                                                             "  "          "         Me OMe  OMe  CH                                     3.038                                                                             "  "          "         "  "    Me   N                                      3.039                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     3.040                                                                             "  "          "         "  "    Cl   CH                                     3.041                                                                             "  "          "         "  Me   Me   CH                                     3.042                                                                             "  "          "         "  OMe  Me   N                                      3.043                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      3.044                                                                             "  "          "         Me OMe  OMe  CH                                     3.045                                                                             "  "          "         "  OMe  Me   N                                      3.046                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     3.047                                                                             "  "          "         "  "    "    N                                      3.048                                                                             "  "          "         "  OMe  Me   N                                      3.049                                                                             "  "          "         "  Me   Me   CH                                     3.050                                                                             "  "          "         "  OMe  Cl   CH                                     3.051                                                                             "  "          "         Me Me   OMe  N                                      3.052                                                                             "  "          "         "  OMe  OMe  CH                                     3.053                                                                             Me COCCl.sub.3                                                                               CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     3.054                                                                             "  "          "         "  "    "    N                                      3.055                                                                             "  "          "         "  OMe  Me   N                                      3.056                                                                             "  "          "         "  OMe  Cl   CH                                     3.057                                                                             "  "          "         "  Me   Me   CH                                     3.058                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      3.059                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      3.060                                                                             "  "          "         "  OMe  OMe  CH                                     3.061                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     3.062                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.063                                                                             "  "          "         H  OMe  Me   N                                      3.064                                                                             "  "          "         "  Me   Me   CH                                     3.065                                                                             "  "          "         "  Cl   OMe  CH                                     3.066                                                                             "  "          "         Me OMe  OMe  CH                                     3.067                                                                             "  "          "         "  OMe  Me   N                                      3.068                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     3.069                                                                             "  "          "         "  OMe  Me   CH                                     3.070                                                                             "  "          "         "  Cl   OMe  CH                                     3.071                                                                             "  "          "         "  OMe  Me   N                                      3.072                                                                             "  "          "         Me OMe  OMe  CH                                     3.073                                                                             "  "          "         "  "    Me   N                                      3.074                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     3.075                                                                             "  "          "         "  OMe  Me   N                                      3.076                                                                             "  "          "         "  OMe  Cl   CH                                     3.077                                                                             "  "          "         "  Me   Me   CH                                     3.078                                                                             "  "          "         Me OMe  OMe  CH                                     3.079                                                                             "  "          "         "  OMe  Me   N                                      3.080                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     3.081                                                                             "  "          "         "  OMe  Me   N                                      3.082                                                                             "  "          "         "  Me   Me   CH                                     3.083                                                                             "  "          "         Me OMe  Me   N                                      3.084                                                                             n-Pr                                                                              COCCl.sub.3                                                                               CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.085                                                                             "  "          "         "  "    Cl   CH                                     3.086                                                                             "  "          "         "  Me   Me   CH                                     3.087                                                                             "  "          "         "  OMe  Me   N                                      3.088                                                                             "  "          "         Me OMe  OMe  CH                                     3.089                                                                             "  "          "         "  OMe  Me   N                                      3.090                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      3.091                                                                             "  "          "         "  "    OMe  CH                                     3.092                                                                             "  "          "         "  Me   Me   CH                                     3.093                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     3.094                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.095                                                                             "  "          "         "  OMe  Me   N                                      3.096                                                                             "  "          "         "  Me   Me   CH                                     3.097                                                                             "  "          "         "  Cl   OMe  N                                      3.098                                                                             "  "          "         Me OMe  Me   N                                      3.099                                                                             "  "          "         "  "    OMe  CH                                     3.100                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.101                                                                             "  "          "         "  "    Cl   CH                                     3.102                                                                             "  "          "         "  Me   Me   CH                                     3.103                                                                             "  "          "         "  OMe  Me   N                                      3.104                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     3.105                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     3.106                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     3.107                                                                             Me COCHCl.sub.2                                                                              CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.108                                                                             "  "          "         "  "    OMe  N                                      3.109                                                                             "  "          "         "  "    Me   N                                      3.110                                                                             "  "          "         "  "    "    CH                                     3.111                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      3.112                                                                             "  "          "         "  Me   Me   CH                                     3.113                                                                             "  "          "         "  "    "    N                                      3.114                                                                             "  "          "         "  Cl   OMe  CH                                     3.115                                                                             "  "          "         Me OMe  OMe  CH                                     3.116                                                                             "  "          "         "  "    Me   N                                      3.117                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     3.118                                                                             "  "          "         "  "    Cl   CH                                     3.119                                                                             "  "          "         "  Me   Me   CH                                     3.120                                                                             "  "          "         "  OMe  Me   N                                      3.121                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      3.122                                                                             "  "          "         Me OMe  OMe  CH                                     3.123                                                                             "  "          "         "  OMe  Me   N                                      3.124                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     3.125                                                                             "  "          "         "  "    "    N                                      3.126                                                                             "  "          "         "  OMe  Me   N                                      3.127                                                                             "  "          "         "  Me   Me   CH                                     3.128                                                                             "  "          "         "  OMe  Cl   CH                                     3.129                                                                             "  "          "         Me Me   OMe  N                                      3.130                                                                             "  "          "         "  OMe  OMe  CH                                     3.131                                                                             Me COCHCl.sub.2                                                                              CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     3.132                                                                             "  "          "         "  "    "    N                                      3.133                                                                             "  "          "         "  OMe  Me   N                                      3.134                                                                             "  "          "         "  OMe  Cl   CH                                     3.135                                                                             "  "          "         "  Me   Me   CH                                     3.136                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      3.137                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      3.138                                                                             "  "          "         "  OMe  OMe  CH                                     3.139                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     3.140                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.141                                                                             "  "          "         H  OMe  Me   N                                      3.142                                                                             "  "          "         "  Me   Me   CH                                     3.143                                                                             "  "          "         "  Cl   OMe  CH                                     3.144                                                                             "  "          "         Me OMe  OMe  CH                                     3.145                                                                             "  "          "         "  OMe  Me   N                                      3.146                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     3.147                                                                             "  "          "         "  OMe  Me   CH                                     3.148                                                                             "  "          "         "  Cl   OMe  CH                                     3.149                                                                             "  "          "         "  OMe  Me   N                                      3.150                                                                             "  "          "         Me OMe  OMe  CH                                     3.151                                                                             "  "          "         "  "    Me   N                                      3.152                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     3.153                                                                             "  "          "         "  OMe  Me   N                                      3.154                                                                             "  "          "         "  OMe  Cl   CH                                     3.155                                                                             "  "          "         "  Me   Me   CH                                     3.156                                                                             "  "          "         Me OMe  OMe  CH                                     3.157                                                                             "  "          "         "  OMe  Me   N                                      3.158                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     3.159                                                                             "  "          "         "  OMe  Me   N                                      3.160                                                                             "  "          "         "  Me   Me   CH                                     3.161                                                                             "  "          "         Me OMe  Me   N                                      3.162                                                                             n-Pr                                                                              COCHCl.sub.2                                                                              CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.163                                                                             "  "          "         "  "    Cl   CH                                     3.164                                                                             "  "          "         "  Me   Me   CH                                     3.165                                                                             "  "          "         "  OMe  Me   N                                      3.166                                                                             "  "          "         Me OMe  OMe  CH                                     3.167                                                                             "  "          "         "  OMe  Me   N                                      3.168                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      3.169                                                                             "  "          "         "  "    OMe  CH                                     3.170                                                                             "  "          "         "  Me   Me   CH                                     3.171                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     3.172                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.173                                                                             "  "          "         "  OMe  Me   N                                      3.174                                                                             "  "          "         "  Me   Me   CH                                     3.175                                                                             "  "          "         "  Cl   OMe  N                                      3.176                                                                             "  "          "         Me OMe  Me   N                                      3.177                                                                             "  "          "         "  "    OMe  CH                                     3.178                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.179                                                                             "  "          "         "  "    Cl   CH                                     3.180                                                                             "  "          "         "  Me   Me   CH                                     3.181                                                                             "  "          "         "  OMe  Me   N                                      3.182                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     3.183                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     3.184                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     3.185                                                                             Me COCH.sub.2 Cl                                                                             CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.186                                                                             "  "          "         "  "    OMe  N                                      3.187                                                                             "  "          "         "  "    Me   N                                      3.188                                                                             "  "          "         "  "    "    CH                                     3.189                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      3.190                                                                             "  "          "         "  Me   Me   CH                                     3.191                                                                             "  "          "         "  "    "    N                                      3.192                                                                             "  "          "         "  Cl   OMe  CH                                     3.193                                                                             "  "          "         Me OMe  OMe  CH                                     3.194                                                                             "  "          "         "  "    Me   N                                      3.195                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     3.196                                                                             "  "          "         "  "    Cl   CH                                     3.197                                                                             "  "          "         "  Me   Me   CH                                     3.198                                                                             "  "          "         "  OMe  Me   N                                      3.199                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      3.200                                                                             "  "          "         Me OMe  OMe  CH                                     3.201                                                                             "  "          "         "  OMe  Me   N                                      3.202                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     3.203                                                                             "  "          "         "  "    "    N                                      3.204                                                                             "  "          "         "  OMe  Me   N                                      3.205                                                                             "  "          "         "  Me   Me   CH                                     3.206                                                                             "  "          "         "  OMe  Cl   CH                                     3.207                                                                             "  "          "         Me Me   OMe  N                                      3.208                                                                             "  "          "         "  OMe  OMe  CH                                     3.209                                                                             Me COCH.sub.2 Cl                                                                             CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     3.210                                                                             "  "          "         "  "    "    N                                      3.211                                                                             "  "          "         "  OMe  Me   N                                      3.212                                                                             "  "          "         "  OMe  Cl   CH                                     3.213                                                                             "  "          "         "  Me   Me   CH                                     3.214                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      3.215                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      3.216                                                                             "  "          "         "  OMe  OMe  CH                                     3.217                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     3.218                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.219                                                                             "  "          "         H  OMe  Me   N                                      3.220                                                                             "  "          "         "  Me   Me   CH                                     3.221                                                                             "  "          "         "  Cl   OMe  CH                                     3.222                                                                             "  "          "         Me OMe  OMe  CH                                     3.223                                                                             "  "          "         "  OMe  Me   N                                      3.224                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     3.225                                                                             "  "          "         "  OMe  Me   CH                                     3.226                                                                             "  "          "         "  Cl   OMe  CH                                     3.227                                                                             "  "          "         "  OMe  Me   N                                      3.228                                                                             "  "          "         Me OMe  OMe  CH                                     3.229                                                                             "  "          "         "  "    Me   N                                      3.230                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     3.231                                                                             "  "          "         "  OMe  Me   N                                      3.232                                                                             "  "          "         "  OMe  Cl   CH                                     3.233                                                                             "  "          "         "  Me   Me   CH                                     3.234                                                                             "  "          "         Me OMe  OMe  CH                                     3.235                                                                             "  "          "         "  OMe  Me   N                                      3.236                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     3.237                                                                             "  "          "         "  OMe  Me   N                                      3.238                                                                             "  "          "         "  Me   Me   CH                                     3.239                                                                             "  "          "         Me OMe  Me   N                                      3.240                                                                             n-Pr                                                                              COCH.sub.2 Cl                                                                             CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.241                                                                             "  "          "         "  "    Cl   CH                                     3.242                                                                             "  "          "         "  Me   Me   CH                                     3.243                                                                             "  "          "         "  OMe  Me   N                                      3.244                                                                             "  "          "         Me OMe  OMe  CH                                     3.245                                                                             "  "          "         "  OMe  Me   N                                      3.246                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      3.247                                                                             "  "          "         "  "    OMe  CH                                     3.248                                                                             "  "          "         "  Me   Me   CH                                     3.249                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     3.250                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.251                                                                             "  "          "         "  OMe  Me   N                                      3.252                                                                             "  "          "         "  Me   Me   CH                                     3.253                                                                             "  "          "         "  Cl   OMe  N                                      3.254                                                                             "  "          "         Me OMe  Me   N                                      3.255                                                                             "  "          "         "  "    OMe  CH                                     3.256                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.257                                                                             "  "          "         "  "    Cl   CH                                     3.258                                                                             "  "          "         "  Me   Me   CH                                     3.259                                                                             "  "          "         "  OMe  Me   N                                      3.260                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     3.261                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  "    "    CH                                     3.262                                                                             "  "          CO.sub.2 -i-Pr                                                                           "  "    "    CH                                     3.263                                                                             Me COCF.sub.3 CO.sub.2 Me                                                                              H  OMe  OMe  CH                                     3.264                                                                             "  "          "         "  "    OMe  N                                      3.265                                                                             "  "          "         "  "    Me   N                                      3.266                                                                             "  "          "         "  "    "    CH                                     3.267                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      3.268                                                                             "  "          "         "  Me   Me   CH                                     3.269                                                                             "  "          "         "  "    "    N                                      3.270                                                                             "  "          "         "  Cl   OMe  CH                                     3.271                                                                             "  "          "         Me OMe  OMe  CH                                     3.272                                                                             "  "          "         "  "    Me   N                                      3.273                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     3.274                                                                             "  "          "         "  "    Cl   CH                                     3.275                                                                             "  "          "         "  Me   Me   CH                                     3.276                                                                             "  "          "         "  OMe  Me   N                                      3.277                                                                             "  "          "         "  NMe.sub.2                                                                           OCH.sub.2 CF.sub.3                                                                  N                                      3.278                                                                             "  "          "         Me OMe  OMe  CH                                     3.279                                                                             "  "          "         "  OMe  Me   N                                      3.280                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     3.281                                                                             "  "          "         "  "    "    N                                      3.282                                                                             "  "          "         "  OMe  Me   N                                      3.283                                                                             "  "          "         "  Me   Me   CH                                     3.284                                                                             "  "          "         "  OMe  Cl   CH                                     3.285                                                                             "  "          "         Me Me   OMe  N                                      3.286                                                                             "  "          "         "  OMe  OMe  CH                                     3.287                                                                             Me COCF.sub.3 CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     3.288                                                                             "  "          "         "  "    "    N                                      3.289                                                                             "  "          "         "  OMe  Me   N                                      3.290                                                                             "  "          "         "  OMe  Cl   CH                                     3.291                                                                             "  "          "         "  Me   Me   CH                                     3.292                                                                             "  "          "         "  SMe  NEt.sub.2                                                                           N                                      3.293                                                                             "  "          CO.sub.2 -i-Pr                                                                           Me OMe  Me   N                                      3.294                                                                             "  "          "         "  OMe  OMe  CH                                     3.295                                                                             Me "          CO.sub.2 -Allyl                                                                          H  OMe  OMe  CH                                     3.296                                                                             Et "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.297                                                                             "  "          "         H  OMe  Me   N                                      3.298                                                                             "  "          "         "  Me   Me   CH                                     3.299                                                                             "  "          "         "  Cl   OMe  CH                                     3.300                                                                             "  "          "         Me OMe  OMe  CH                                     3.301                                                                             "  "          "         "  OMe  Me   N                                      3.302                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     3.303                                                                             "  "          "         "  OMe  Me   CH                                     3.304                                                                             "  "          "         "  Cl   OMe  CH                                     3.305                                                                             "  "          "         "  OMe  Me   N                                      3.306                                                                             "  "          "         Me OMe  OMe  CH                                     3.307                                                                             "  "          "         "  "    Me   N                                      3.308                                                                             "  "          CO.sub.2 -n-Pr                                                                           H  OMe  OMe  CH                                     3.309                                                                             "  "          "         "  OMe  Me   N                                      3.310                                                                             "  "          "         "  OMe  Cl   CH                                     3.311                                                                             "  "          "         "  Me   Me   CH                                     3.312                                                                             "  "          "         Me OMe  OMe  CH                                     3.313                                                                             "  "          "         "  OMe  Me   N                                      3.314                                                                             "  "          CO.sub.2 -i-Pr                                                                           H  OMe  OMe  CH                                     3.315                                                                             "  "          "         "  OMe  Me   N                                      3.316                                                                             "  "          "         "  Me   Me   CH                                     3.317                                                                             "  "          "         Me OMe  Me   N                                      3.318                                                                             n-Pr                                                                              COCF.sub.3 CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.319                                                                             "  "          "         "  "    Cl   CH                                     3.320                                                                             "  "          "         "  Me   Me   CH                                     3.321                                                                             "  "          "         "  OMe  Me   N                                      3.322                                                                             "  "          "         Me OMe  OMe  CH                                     3.323                                                                             "  "          "         "  OMe  Me   N                                      3.324                                                                             n-Pr                                                                              "          CO.sub.2 -Et                                                                             H  "    "    N                                      3.325                                                                             "  "          "         "  "    OMe  CH                                     3.326                                                                             "  "          "         "  Me   Me   CH                                     3.327                                                                             "  "          CO.sub.2 -n-Pr                                                                           "  OMe  OMe  CH                                     3.328                                                                             i-Pr                                                                              "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.329                                                                             "  "          "         "  OMe  Me   N                                      3.330                                                                             "  "          "         "  Me   Me   CH                                     3.331                                                                             "  "          "         "  Cl   OMe  N                                      3.332                                                                             "  "          "         Me OMe  Me   N                                      3.333                                                                             "  "          "         "  "    OMe  CH                                     3.334                                                                             Allyl                                                                             "          CO.sub.2 -Me                                                                             H  OMe  OMe  CH                                     3.335                                                                             "  "          "         "  "    Cl   CH                                     3.336                                                                             "  "          "         "  Me   Me   CH                                     3.337                                                                             "  "          "         "  OMe  Me   N                                      3.338                                                                             "  "          CO.sub.2 -Et                                                                             H  OMe  OMe  CH                                     3.339                                                                             "  "          n-Pr      "  "    "    CH                                     3.340                                                                             "  "          i-Pr      "  "    "    CH                                     3.341                                                                             Me COCH.sub.3 CHO       "  "    "    CH                                     3.342                                                                             "  CO.sub.2 CH.sub.3                                                                         "         "  "    "    CH                                     3.343                                                                             "  COCH.sub.3 COCH.sub.3                                                                               "  "    "    CH                                     3.344                                                                             "  CO.sub.2 CH.sub.3                                                                         "         "  "    "    CH                                     3.345                                                                             "  COCH.sub.3 COS-i-Pr  "  "    "    CH                                     3.346                                                                             "  CO.sub.2 Et                                                                               "         "  "    "    CH                                     3.347                                                                             "  CHO        CONMe.sub.2                                                                              "  "    "    CH                                                                               180-181                              3.348                                                                             "  "          "         "  OMe  Me   N                                      3.349                                                                             "  COCH.sub.3 "         "  OMe  OMe  CH                                                                               174-175                              3.350                                                                             "  "          CONH.sub.2                                                                               "  "    "    CH                                     3.351                                                                             "  COCH.sub.3 CSNMe.sub.2                                                                              "  OMe  OMe  CH                                     3.352                                                                             "  CO.sub.2 Et                                                                               "         "  "    "    CH                                     3.353                                                                             "  COCH.sub.2 CH.sub.3                                                                       "         "  "    "    CH                                     3.354                                                                             "  CO.sub.2 Me                                                                               CSO-i-Pr  "  "    "    CH                                     3.355                                                                             "  CHO        "         "  "    "    CH                                     3.356                                                                             "  "          C(NNMe.sub.2)                                                                            "  "    "    CH                                     3.357                                                                             Me COCH.sub.3 C(NOMe)OMe                                                                               H  OMe  OMe  CH                                     3.358                                                                             "  CO.sub.2 CH.sub.3                                                                         H         "  "    "    CH                                     3.359                                                                             "  CHO        "         "  "    "    CH                                     3.360                                                                             "  "          C(NOH)H   "  "    "    CH                                     3.361                                                                             "  CO.sub.2 Me                                                                               "         "  "    "    CH                                     3.362                                                                             "  COCH.sub.3 C(NOMe)H  "  "    "    CH                                     3.363                                                                             "  "          CO.sub.2 H                                                                               "  "    "    CH                                     3.364                                                                             "  CO.sub.2 Me                                                                               "         "  "    "    CH                                     3.365                                                                             "  COCH.sub.3 C(N-Et)OMe                                                                               "  "    "    CH                                     3.366                                                                             "  "          C(N-i-Pr)H                                                                               "  "    "    CH                                     3.367                                                                             "  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             COOMe     H  OMe  OMe  CH                                                                               141-143                              3.368                                                                             Me CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             COOMe     H  OCH.sub.2 CF.sub.3                                                                  NMe.sub.2                                                                           N 123-126                              3.369                                                                             Me COCH.sub.2 CH.sub.3                                                                       CONMe.sub.2                                                                              H  OMe  OMe  CH                                                                               159-161                              3.370                                                                             Me COOMe      CONMe.sub.2                                                                              H  OMe  OMe  CH                                                                               133                                  3.371                                                                             Me CO-.sup.n C.sub.4 H.sub.9                                                                 COOMe     H  OMe  OMe  CH                                                                               189-191                              __________________________________________________________________________

B) FORMULATION EXAMPLES

a) A dusting agent is obtained by mixing 10 parts by weight of a compound of the formula (I) and 90 parts by weight of talc as inert substance, and comminuting them in an impact mill.

b) A wettable powder which is easily dispersible in water is obtained by mixing 25 parts by weight of a compound of the formula (I), 64 parts by weight of kaolin-containing quartz as inert substance, 10 parts by weight of potassium ligninsulfonate and part by weight of sodium oleoylmethyltaurine as wetting and dispersing agent, and milling them in a pin mill.

c) A dispersion concentrate which is easily dispersible in water is obtained by mixing 20 parts by weight of a compound of the formula (I) with 6 parts by weight of alkylphenol polyglycol ether (®Triton X 207), 3 parts by weight of isotridecanol polyglycol ether (8 EO) and 71 parts by weight of paraffinic mineral oil (boiling range e.g. about 255° to over 277° C.) and milling them in an attrition ball mill to a fineness of less than 5 microns.

d) An emulsifiable concentrate is obtained from

15 parts by weight of a compound of the formula (I),

75 parts by weight of cyclohexanone as solvent and

10 parts by weight of ethoxylated nonylphenol as emulsifier.

e) Water-dispersible granules are obtained by mixing

75 parts by weight of a compound of the formula (I),

10 parts by weight of calcium ligninsulfonate,

5 parts by weight of sodium lauryl sulfate,

3 parts by weight of polyvinyl alcohol and

7 parts by weight of kaolin,

milling them in a pin mill and granulating the powder in a fluidized bed, spraying on water as the granulation fluid.

c) BIOLOGICAL EXAMPLES

1. Pre-emergence action on weeds

Seeds and/or pieces of rhizome of mono- and dicotyledon weeds were planted in plastic pots in sandy loam soil and covered with earth. The compounds according to the invention, formulated as wettable powders or emulsifiable concentrates, were then applied as an aqueous suspension or emulsion at an equivalent water application rate of 600 to 800 l/ha in different, metered amounts to the surface of the covering earth.

After treatment, the pots are placed in a greenhouse and maintained under good growth conditions for the weeds. The visual assessment of the plants and/or the emergence damage is made following the emergence of the test plants after a test period of 3 to 4 weeks, in comparison to untreated controls. As the test results show, the compounds according to the invention display a good herbicidal pre-emergence activity against a broad spectrum of graminaceous and other weeds. For example, the compounds from Examples 12, 13, 15, 16, 18, 44, 89, 90, 91, 92, 93, 94, 96, 122, 167, 170, 173, 175, 246, 322, 324, 325, 327, 477, 555, 945, 1.023, 1.178, 1.256, 1.334, 1.802, 2.192, 2.270, 2.715, 2.951, 3.347, 3.349, 3.367, 3.368, 3.369, 3.370 and 3.371 from Table 1 have a very good herbicidal action against harmful plants such as Sinapis alba, Chrysanthemum segetum, Avena sative, Stellaria media, Echinochloa crus-galli and Lolium multiflorum in the pre-emergence method at an application rate of 0.3 kg or less of active substance per hectare.

2. Post-emergence action on weeds

Seeds and/or pieces of rhizome from mono- and dicotyledon weeds were placed in plastic pots in sandy loam soil, covered with earth and cultivated in a greenhouse under good growth conditions. Three weeks after being sown, the test plants were treated at the three-leaf stage.

The compounds according to the invention, formulated as wettable powders or as emulsifiable concentrates, were sprayed in different, metered amounts at an equivalent water application rate of 600 to 800 l/ha onto the green parts of the plants: after a 3- to 4-week standing time of the test plants in a greenhouse under optimum growth conditions, the activity of the formulations was assessed visually in comparison to untreated controls. Applied post-emergence, too, the agents according to the invention display a good herbicidal activity against a broad spectrum of economically significant graminaceous and other weeds. For example, the compounds of Examples 12, 13, 15, 16, 18, 44, 89, 90, 91, 92, 93, 94, 96, 122, 167, 170, 173, 175, 246, 322, 324,325, 327, 477, 555, 945, 1.023, 1.178, 1.256, 1.334, 1.802, 2.192, 2.270, 2.715, 2.951, 3.347, 3.349, 3.367, 3.368, 3.369, 3.370 and 3.371 from Table 1 have a very good herbicidal action against harmful plants such as Sinapis alba, Stellaria media, Echinochloa crus-galli, Lolium multiflorum, Chrysanthemum sagetum and Avena sativa in the post-emergence method at an application rate of 0.3 kg or less of active substance per hectare. 

We claim:
 1. A compound of the formula (I) or a salt thereof ##STR31## in which R¹ is C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the 3 latter radicals independently of one another being unsubstituted or substituted by one or more radicals from the group consisting of halogen, C₁ -C₄ -alkoxy, CONH₂, C₁ -C₄ -alkylthio, CN, CHO, (C₁ -C₆ -alkyl)carbonyl, (C₃ -C₆ -cycloalkyl)carbonyl, C₁ -C₄ -alkylsulfonyl, carboxyl, (C₁ -C₄ -alkoxy)carbonyl, (C₂ -C₄ -alkenyloxy)carbonyl, (C₂ -C₄ -alkynyloxy)carbonyl, NO₂, NH₂, mono- and di-(C₁ -C₆)-alkylamino,R² is CO--R⁵, COO--R⁵, CO--SR⁷, CO--NR⁸ R⁹, CS--NR¹⁰ R¹¹, CS--OR¹², CS--SR¹³, SO₂ R¹⁴, SO₂ NR¹⁵ R¹⁶, R³ is COR¹⁷, CO--OR¹⁸, CO--NR¹⁹ R²⁰, CO--SR²¹, COO--N═CR²² R²³, CSR²⁴, CSSR²⁵, CS--OR²⁶, CS--NR²⁷ R²⁸, C(═NR²⁹)R³⁰, R⁴ is H, C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the 3 latter radicals independently of one another being unsubstituted or substituted by one or more halogen radicals, R⁵ is H, C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the three latter radicals independently of one another being unsubstituted or substituted by one or more radicals from the group, consisting of halogen, C₁ -C₄ -alkoxy, C₁ -C₄ -alkylthio and NR³¹ R³², or unsubstituted or substituted C₃ -C₈ -cycloalkyl, unsubstituted or substituted phenyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, thienyl, thiazolyl, oxazolyl, furyl, pyrrolyl, pyrazolyl or imidazolyl, where each of the eleven last-mentioned radicals is unsubstituted or substituted by one or more radicals from the group consisting of C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy and halogen or phenyl-C₁ -C₄ -alkyl which is unsubstituted or substituted on the phenyl ring, R⁶ is C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the three latter radicals independently of one another being unsubstituted or substituted by one or more radicals from the group consisting of halogen, C₁ -C₄ -alkoxy, C₁ -C₄ -alkylthio and NR³¹ R³², or C₃ -C₆ -cycloalkyl which is unsubstituted or substituted by one or more radicals from the group consisting of halogen, C₁ -C₄ -alkyl and C₁ -C₄ -alkoxy, or C₃ -C₆ -cycloalkyl-C₁ -C₃ -alkyl, R⁷ is selected from the group of radicals as defined in R⁶, R⁸ is H, C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the 3 latter radicals independently of one another being unsubstituted or substituted by one or more radicals from the group consisting of halogen, or (C₁ -C₆)-alkoxy)carbonyl or C₁ -C₄ -alkoxy, R⁹ is H, C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the 3 latter radicals independently of one another being unsubstituted or substituted by one or more radicals from the group consisting of halogen, C₁ -C₄ -alkoxy, C₁ -C₄ -alkylthio and NR³¹ R³², or CO--R³³, CO--OR³⁴, CO--NR³⁵ R³⁶, CS--NR³⁵ R³⁶, CS--R³³ or CS--OR³⁴, or R⁸, R⁹ taken together are a divalent radical of the formula --(CH₂)₄ --, --(CH₂)₅ --, --CH₂ CH₂ --O--CH₂ CH₂ --, --CH₂ CH₂ NHCH₂ CH₂ --, the 4 latter radicals being unsubstituted or substituted by C₁ -C₄ -alkyl, R¹⁰ is selected from the group of radicals as defined in R⁸, R¹¹ is selected from the group of radicals as defined in R⁹, R¹² is selected from the group of radicals as defined in R⁶, R¹³ is selected from the group of radicals as defined in R⁶, R¹⁴ is C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the three latter radicals independently of one another being unsubstituted or substituted by one or more radicals from the group consisting of halogen, C₁ -C₄ -alkoxy, C₁ -C₄ -alkylthio and NR³¹ R³², R¹⁵ is selected from the group of radicals as defined in R⁸, R¹⁶ is H, C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the 3 latter radicals independently of one another being unsubstituted or substituted by one or more halogen radicals, R¹⁷ is selected from the group of radicals as defined in R⁵, R¹⁸ is C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the three latter radicals independently of one another being unsubstituted or substituted by one or more radicals from the group consisting of halogen, C₁ -C₄ -alkoxy, C₁ -C₄ -alkylthio and NR³¹ R³², or C₃ -C₆ -cycloalkyl which is unsubstituted or substituted by one or more radicals from the group consisting of halogen, C₁ -C₄ -alkyl and C₁ -C₄ -alkoxy, or C₃ -C₆ -cycloalkyl-C₁ -C₃ -alkyl or H, R¹⁹ is selected from the group of radicals as defined in R⁸, R²⁰ is selected from the group of radicals as defined in R⁹, R²¹ is selected from the group of radicals as defined in R¹⁸, R²² is H, C₁ -C₄ -alkyl, C₃ -C₅ -alkenyl or C₃ -C₅ -alkynyl, R²³ is H, C₁ -C₄ -alkyl, C₃ -C₅ -alkenyl or C₃ -C₅ -alkynyl, R²⁴ is selected from the group of radicals as defined in R¹⁷, R²⁵ is selected from the group of radicals as defined in R¹⁸, R²⁶ is selected from the group of radicals as defined in R¹⁸, R²⁷ is selected from the group of radicals as defined in R⁸, R²⁸ is selected from the group of radicals as defined in R⁹, R²⁹ is H, OH, NH₂, NHR³⁷, N(R³⁷)₂, C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₂ -C₄ -alkenyl or C₂ -C₄ -alkynyl, the 4 latter radicals independently of one another being unsubstituted or substituted by one or more radicals from the group consisting of halogen, C₁ -C₃ -alkoxy and C₁ -C₃ -alkylthio, R³⁰ is H, C₁ -C₆ -alkyl, C₁ -C₆ -alkoxy, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the four latter radicals independently of one another being unsubstituted or substituted by one or more radicals from the group consisting of halogen, C₁ -C₃ -alkoxy and C₁ -C₃ -alkylthio,each R³¹ independently of the others is H, C₁ -C₄ -alkyl, (C₁ -C₄ -alkyl)carbonyl, (C₁ -C₄ -alkoxy)carbonyl or CHO,each R³² independently of the others is H or C₁ -C₄ -alkyl, R³³ is selected from the group of radicals as defined in R⁵, R³⁴ is selected from the group of radicals as defined in R⁶, R³⁵, R³⁶ independently of one another are H, C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, the 3 latter radicals independently of one another being unsubstituted or substituted by one or more halogen radicals, R³⁷ is C₁ -C₄ -alkyl, C₂ -C₄ -alkenyl or C₂ -C₄ -alkynyl, the three radicals mentioned, independently of one another, being unsubstituted or substituted by one or more radicals from the group consisting of halogen, C₁ -C₄ -alkoxy and C₁ -C₄ -alkylthio, W is O or S, X and Y independently of one another are hydrogen, halogen, C₁ -C₆ -alkyl, C₁ -C₆ -alkoxy or C₁ -C₆ -alkylthio, the three latter radicals being unsubstituted or substituted by one or more radicals from the group consisting of halogen, C₁ -C₄ -alkoxy and C₁ -C₄ -alkylthio, or mono- or di-(C₁ -C₄ -alkyl)amino, C₃ -C₆ -cycloalkyl, C₃ -C₅ -alkenyl, C₃ -C₅ -alkenyloxy or C₃ -C₅ -alkynyloxy, and Z is CH.
 2. A compound or a salt thereof as claimed in claim 1, whereinR¹ is C₁ -C₄ -alkyl, C₂ -C₄ -alkenyl or C₂ -C₄ -alkynyl, or R² is CO--R⁵, COOR⁶, CO--NR⁸ R⁹, CS--NR¹⁰ R¹¹, SO₂ R¹⁴ or SO₂ NR¹⁵ R¹⁶, or R³ is COR¹⁷, COOR¹⁸, CONR¹⁹ R²⁰ or CO--ON═CR²² R²³, or R⁴ is H, C₁ -C₄ -alkyl, or R⁵ is H, C₁ -C₆ -alkyl which is unsubstituted or substituted by one or more halogen atoms, or by C₁ -C₄ -alkoxy, C₁ -C₄ -alkylthio, or NR³¹ R³², or is C₃ -C₆ -cycloalkyl, phenyl, benzyl or pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, thienyl, thiazolyl, oxazolyl, furyl, pyrrolyl, pyrazolyl, imidazolyl, the thirteen latter radicals being unsubstituted or substituted by one or more radicals from the group consisting of C₁ -2C₄ -alkyl, C₁ -C₄ -alkoxy and halogen, or R⁶ is C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl, C₁ -C₆ -haloalkyl or C₃ -C₆ -cycloalkyl, or R⁷ is C₁ -C₄ -alkyl, R⁸ is hydrogen, C₁ -C₆ -alkyl, C₁ -C₄ -haloalkyl, C₁ -C₄ -alkoxy or (C₁ -C₄ -alkoxy)carbonyl, R⁹ is hydrogen, C₁ -C₆ -alkyl which is unsubstituted or substituted by one or more radicals from the group consisting of halogen, C₁ -C₄ -alkoxy and NR³¹ R³², or CO--R³³, CO--OR³⁴ or CO--NR³⁵ R³⁶, or R⁸ and R⁹ taken together are a divalent radical of the formula --(CH₂)₄ --, --(CH₂)₅ -- or --CH₂ CH₂ --O--CH₂ CH₂ --, or R¹⁴ is C₁ -C₆ -alkyl or C₂ -C₆ -haloalkyl, or R¹⁵, R¹⁶ independently of one another are hydrogen or C₁ -C₄ -alkyl, or R¹⁷ is hydrogen or C₁ -C₄ -alkyl, C₁ -C₄ -haloalkyl, C₃ -C₆ -cycloalkyl, phenyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, thienyl, thiazolyl, oxazolyl, furyl, pyrrolyl, pyrazolyl, imidazolyl, the latter twelve radicals being unsubstituted or substituted, by one or more radicals from the group consisting of C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy and halogen or R¹⁸ is hydrogen, C₁ -C₄ -alkyl, C₂ -C₆ -alkenyl or C₂ -C₆ -alkynyl, the 3 latter radicals being unsubstituted or substituted by one or more radicals from the group consisting of halogen, C₁ -C₄ -alkoxy, C₁ -C₄ -alkylthio and NR³¹ R³², or C₃ -C₆ -cycloalkyl or C₃ -C₆ -cycloalkyl-C₁ -C₃ -alkyl, or R²² is hydrogen or C₁ -C₂ -alkyl, or R²³ is hydrogen or C₁ -C₂ -alkyl, or R²⁹ is hydrogen, hydroxyl, amino, NHCH₃, N(CH₃)₂, C₁ -C₄ -alkyl or C₁ -C₄ -alkoxy, R³⁰ is hydrogen or C₁ -C₄ -alkyl, oreach R³¹ independently of the others is H or C₁ -C₄ -alkyl, oreach R³² independently of the others is H or C₁ -C₄ -alkyl, or R³³ is hydrogen, C₁ -C₄ -alkyl, C₁ -C₄ -haloalkyl, C₃ -C₆ -cycloalkyl or phenyl which is unsubstituted or substituted by one or more radicals from the group consisting of halogen, C₁ -C₄ -alkyl and C₁ -C₄ -alkoxy, or R³⁴ is C₁ -C₄ -alkyl, allyl, propargyl or cycloalkyl, or R³⁵ is hydrogen or C₁ -C₄ -alkyl, or R³⁶ is hydrogen or C₁ -C₄ -alkyl, or X is C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₁ -C₄ -haloalkyl, C₁ -C₄ -alkylthio, halogen or mono- or di-(C₁ -C₂ -alkyl)amino, or Y is C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₁ -C₄ -haloalkyl or C₁ -C₄ -alkylthio.
 3. A compound or a salt thereof as claimed in claim 1, whereinR¹ is methyl, ethyl, n-propyl, i-propyl or allyl, R² is CO--R⁵, COOR⁶, CO--NR⁸ R⁹, CS--NR¹⁰ R¹¹, SO₂ R¹⁴ or SO₂ NR¹⁵ R¹⁶, R⁵ is H, C₁ -C₄ -alkyl, C₁ -C₂ -haloalkyl, cyclopropyl, phenyl, benzyl or pyridyl, thienyl or furyl, where each of the 5 latter radicals are unsubstituted or substituted by one or more halogen atoms, R⁶ is C₁ -C₄ -alkyl, allyl, propargyl or cyclopropyl, R⁸ is H, C₁ -C₄ -alkyl, C₁ -C₄ -haloalkyl or (C₁ -C₄ -alkoxy)carbonyl, R⁹ is H or C₁ -C₄ -alkyl, R¹⁰ is H or C₁ -C₄ -alkyl, R¹¹ is H or C₁ -C₄ -alkyl, R¹⁴ is C₁ -C₄ -alkyl, R¹⁵ is H or C₁ -C₄ -alkyl and R¹⁶ is H or C₁ -C₄ -alkyl.
 4. A herbicidal or plant growth-regulating composition, which comprises a compound of the formula (I) as claimed in claim 1 and conventional formulation auxiliaries.
 5. A method of controlling harmful plants or of regulating the growth of plants, which comprises applying an effective amount of one or more compounds of the formula (I) or of salts thereof as claimed in claim 1, to the plants, parts of plants or the agricultural or industrial land.
 6. A compound of formula (I) or a salt thereof as claimed in claim 1, whereinR¹ is methyl, ethyl, n-propyl, i-propyl or allyl, R² is formyl, acetyl, methoxycarbonyl, ethoxycarbonyl, 2-chloroethoxycarbonyl, ethoxycarbonylaminothiocarbonyl, methylaminosulfonyl or methylsulfonyl, R³ is methoxycarbonyl or ethoxycarbonyl, R⁴ is hydrogen or methyl, W is O, X is methyl, methoxy or chloro, Y is methyl or methoxy, and Z is CH.
 7. A compound or a salt thereof as claimed in claim 6 whereinR¹ is methyl, ethyl, n-propyl, i-propyl or allyl, R² is formyl, acetyl, methoxycarbonyl or ethoxycarbonyl, and R³ is methoxycarbonyl. 